Immune Response Mechanisms against AAV Vectors in Animal Models

por Martino, Ashley T., Markusic, David M.
Publicado 2019

Editorial: Induction of immune tolerance: addressing unmet medical need in immune mediated diseases and immune responses to biologics

por Rosenberg, Amy S., Tourdot, Sophie, Markusic, David
Publicado 2023

Editorial: Immunogenicity and toxicity of AAV gene therapy

por Bradbury, Allison, Markusic, David, Muhuri, Manish, Ou, Li
Publicado 2023

Separating Lentiviral Vector Injection and Induction of Gene Expression in Time, Does Not Prevent an Immune Response to rtTA in Rats

por Markusic, David M., de Waart, Dirk R., Seppen, Jurgen
Publicado 2010

Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter

por Markusic, David, Oude-Elferink, Ronald, Das, Atze T., Berkhout, Ben, Seppen, Jurgen
Publicado 2005

Development of gene transfer for induction of antigen-specific tolerance

por Sack, Brandon K, Herzog, Roland W, Terhorst, Cox, Markusic, David M
Publicado 2014

An Immune-Competent Murine Model to Study Elimination of AAV-Transduced Hepatocytes by Capsid-Specific CD8(+) T Cells

por Palaschak, Brett, Marsic, Damien, Herzog, Roland W., Zolotukhin, Sergei, Markusic, David M.
Publicado 2017

B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

por Biswas, Moanaro, Palaschak, Brett, Kumar, Sandeep R. P., Rana, Jyoti, Markusic, David M.
Publicado 2020

Clinical development of gene therapy: results and lessons from recent successes

por Kumar, Sandeep RP, Markusic, David M, Biswas, Moanaro, High, Katherine A, Herzog, Roland W
Publicado 2016

Reduction of liver macrophage transduction by pseudotyping lentiviral vectors with a fusion envelope from Autographa californica GP64 and Sendai virus F2 domain

por Markusic, David M, van Til, Niek P, Hiralall, Johan K, Elferink, Ronald PJ Oude, Seppen, Jurgen
Publicado 2009

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

por Zolotukhin, Irene, Markusic, David M, Palaschak, Brett, Hoffman, Brad E, Srikanthan, Meera A, Herzog, Roland W
Publicado 2016

Single-dose AAV vector gene immunotherapy to treat food allergy

por Gonzalez-Visiedo, Miguel, Li, Xin, Munoz-Melero, Maite, Kulis, Michael D., Daniell, Henry, Markusic, David M.
Publicado 2022

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis

por Keeler, Geoffrey D., Kumar, Sandeep, Palaschak, Brett, Silverberg, Emily L., Markusic, David M., Jones, Noah T., Hoffman, Brad E.
Publicado 2018

Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

por Sack, Brandon K., Merchant, Sherin, Markusic, David M., Nathwani, Amit C., Davidoff, Andrew M., Byrne, Barry J., Herzog, Roland W.
Publicado 2012

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

por Martino, Ashley T., Nayak, Sushrusha, Hoffman, Brad E., Cooper, Mario, Liao, Gongxian, Markusic, David M., Byrne, Barry J., Terhorst, Cox, Herzog, Roland W.
Publicado 2009

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

por Markusic, David M., Nichols, Timothy C., Merricks, Elizabeth P., Palaschak, Brett, Zolotukhin, Irene, Marsic, Damien, Zolotukhin, Sergei, Srivastava, Arun, Herzog, Roland W.
Publicado 2017

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

por Markusic, David M, Hoffman, Brad E, Perrin, George Q, Nayak, Sushrusha, Wang, Xiaomei, LoDuca, Paul A, High, Katherine A, Herzog, Roland W
Publicado 2013

Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity

por van Til, Niek P, Heutinck, Kirstin M, van der Rijt, Roos, Paulusma, Coen C, van Wijland, Michel, Markusic, David M, Elferink, Ronald PJ Oude, Seppen, Jurgen
Publicado 2008

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

por Sarkar, Debalina, Biswas, Moanaro, Liao, Gongxian, Seay, Howard R, Perrin, George Q, Markusic, David M, Hoffman, Brad E, Brusko, Todd M, Terhorst, Cox, Herzog, Roland W
Publicado 2014

Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette

por Kumar, Sandeep R.P., Xie, Jun, Hu, Shilang, Ko, Jihye, Huang, Qifeng, Brown, Harrison C., Srivastava, Alok, Markusic, David M., Doering, Christopher B., Spencer, H. Trent, Srivastava, Arun, Gao, Guangping, Herzog, Roland W.
Publicado 2021