Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis

por Machado-Oliveira, Gisela, Ramos, Cristiano, Marques, André R. A., Vieira, Otília V.
Publicado 2020

Lysosome (Dys)function in Atherosclerosis—A Big Weight on the Shoulders of a Small Organelle

por Marques, André R. A., Ramos, Cristiano, Machado-Oliveira, Gisela, Vieira, Otília V.
Publicado 2021

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

por Marques, André R. A., Gabriel, Tanit L., Aten, Jan, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Claessen, Nike, Alfonso, Pilar, Irún, Pilar, Giraldo, Pilar, Aerts, Johannes M. F. G., van Eijk, Marco
Publicado 2016

GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice

por van der Lienden, Martijn J. C., Aten, Jan, Marques, André R. A., Waas, Ingeborg S. E., Larsen, Per W. B., Claessen, Nike, van der Wel, Nicole N., Ottenhoff, Roelof, van Eijk, Marco, Aerts, Johannes M. F. G.
Publicado 2021

Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain

por van Rooden, Eva J., van Esbroeck, Annelot C. M., Baggelaar, Marc P., Deng, Hui, Florea, Bogdan I., Marques, André R. A., Ottenhoff, Roelof, Boot, Rolf G., Overkleeft, Herman S., Aerts, Johannes M. F. G., van der Stelt, Mario
Publicado 2018

A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution

por Chen, Yen-Hsi, Tian, Weihua, Yasuda, Makiko, Ye, Zilu, Song, Ming, Mandel, Ulla, Kristensen, Claus, Povolo, Lorenzo, Marques, André R. A., Čaval, Tomislav, Heck, Albert J. R., Sampaio, Julio Lopes, Johannes, Ludger, Tsukimura, Takahiro, Desnick, Robert, Vakhrushev, Sergey Y., Yang, Zhang, Clausen, Henrik
Publicado 2023

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice

por Marques, André R. A., Aten, Jan, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Herrera Moro, Daniela, Claessen, Nike, Vinueza Veloz, María Fernanda, Zhou, Kuikui, Lin, Zhanmin, Mirzaian, Mina, Boot, Rolf G., De Zeeuw, Chris I., Overkleeft, Herman S., Yildiz, Yildiz, Aerts, Johannes M. F. G.
Publicado 2015

Human glucocerebrosidase mediates formation of xylosyl-cholesterol by β-xylosidase and transxylosidase reactions

por Boer, Daphne E., Mirzaian, Mina, Ferraz, Maria J., Zwiers, Kimberley C., Baks, Merel V., Hazeu, Marc D., Ottenhoff, Roelof, Marques, André R.A., Meijer, Rianne, Roos, Jonathan C.P., Cox, Timothy M., Boot, Rolf G., Pannu, Navraj, Overkleeft, Herman S., Artola, Marta, Aerts, Johannes M.
Publicado 2021

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes

por Herrera Moro Chao, Daniela, Kallemeijn, Wouter W., Marques, Andre R. A., Orre, Marie, Ottenhoff, Roelof, van Roomen, Cindy, Foppen, Ewout, Renner, Maria C., Moeton, Martina, van Eijk, Marco, Boot, Rolf G., Kamphuis, Willem, Hol, Elly M., Aten, Jan, Overkleeft, Hermen S., Kalsbeek, Andries, Aerts, Johannes M. F. G.
Publicado 2015

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

por Prieto Huarcaya, Susy, Drobny, Alice, Marques, André R. A., Di Spiezio, Alessandro, Dobert, Jan Philipp, Balta, Denise, Werner, Christian, Rizo, Tania, Gallwitz, Lisa, Bub, Simon, Stojkovska, Iva, Belur, Nandkishore R., Fogh, Jens, Mazzulli, Joseph R, Xiang, Wei, Fulzele, Amitkumar, Dejung, Mario, Sauer, Markus, Winner, Beate, Rose-John, Stefan, Arnold, Philipp, Saftig, Paul, Zunke, Friederike
Publicado 2022

Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1)

por Alegre-Cortés, Eva, Giménez-Bejarano, Alberto, Uribe-Carretero, Elisabet, Paredes-Barquero, Marta, Marques, André R. A., Lopes-da-Silva, Mafalda, Vieira, Otília V., Canales-Cortés, Saray, Camello, Pedro J., Martínez-Chacón, Guadalupe, Aiastui, Ana, Fernández-Torrón, Roberto, López de Munain, Adolfo, Gomez-Suaga, Patricia, Niso-Santano, Mireia, González-Polo, Rosa A., Fuentes, José M., Yakhine-Diop, Sokhna M. S.
Publicado 2022

Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation

por Domingues, Neuza, Gaifem, Joana, Matthiesen, Rune, Saraiva, Diana P., Bento, Luís, Marques, André R.A., Soares, Maria I.L., Sampaio, Julio, Klose, Christian, Surma, Michal A., Almeida, Manuel S., Rodrigues, Gustavo, Gonçalves, Pedro Araújo, Ferreira, Jorge, e Melo, Ryan Gouveia, Pedro, Luís Mendes, Simons, Kai, Pinho e Melo, Teresa M.V.D., Cabral, M. Guadalupe, Jacinto, Antonio, Silvestre, Ricardo, Vaz, Winchil, Vieira, Otília V.
Publicado 2023

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases

por Marques, André R. A., Mirzaian, Mina, Akiyama, Hisako, Wisse, Patrick, Ferraz, Maria J., Gaspar, Paulo, Ghauharali-van der Vlugt, Karen, Meijer, Rianne, Giraldo, Pilar, Alfonso, Pilar, Irún, Pilar, Dahl, Maria, Karlsson, Stefan, Pavlova, Elena V., Cox, Timothy M., Scheij, Saskia, Verhoek, Marri, Ottenhoff, Roelof, van Roomen, Cindy P. A. A., Pannu, Navraj S., van Eijk, Marco, Dekker, Nick, Boot, Rolf G., Overkleeft, Herman S., Blommaart, Edward, Hirabayashi, Yoshio, Aerts, Johannes M.
Publicado 2016

Current methods to analyze lysosome morphology, positioning, motility and function

por Barral, Duarte C., Staiano, Leopoldo, Guimas Almeida, Cláudia, Cutler, Dan F., Eden, Emily R., Futter, Clare E., Galione, Antony, Marques, André R. A., Medina, Diego Luis, Napolitano, Gennaro, Settembre, Carmine, Vieira, Otília V., Aerts, Johannes M. F. G., Atakpa‐Adaji, Peace, Bruno, Gemma, Capuozzo, Antonella, De Leonibus, Elvira, Di Malta, Chiara, Escrevente, Cristina, Esposito, Alessandra, Grumati, Paolo, Hall, Michael J., Teodoro, Rita O., Lopes, Susana S., Luzio, J. Paul, Monfregola, Jlenia, Montefusco, Sandro, Platt, Frances M., Polishchuck, Roman, De Risi, Maria, Sambri, Irene, Soldati, Chiara, Seabra, Miguel C.
Publicado 2022