Progress in Structure Based Drug Design for G Protein-Coupled Receptors

por Congreve, Miles, Langmead, Christopher J., Mason, Jonathan S., Marshall, Fiona H.
Publicado 2011

Conformational thermostabilisation of corticotropin releasing factor receptor 1

por Kean, James, Bortolato, Andrea, Hollenstein, Kaspar, Marshall, Fiona H., Jazayeri, Ali
Publicado 2015

High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

por Mason, Jonathan S, Bortolato, Andrea, Weiss, Dahlia R, Deflorian, Francesca, Tehan, Benjamin, Marshall, Fiona H
Publicado 2013

Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal 
Structures

por Doré, Andrew S., Bortolato, Andrea, Hollenstein, Kaspar, Cheng, Robert K.Y., Read, Randy J., Marshall, Fiona H.
Publicado 2017

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

por Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G., Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H., Bräuner-Osborne, Hans, Gloriam, David E.
Publicado 2015

Biophysical Mapping of the Adenosine A(2A) Receptor

por Zhukov, Andrei, Andrews, Stephen P., Errey, James C., Robertson, Nathan, Tehan, Benjamin, Mason, Jonathan S., Marshall, Fiona H., Weir, Malcolm, Congreve, Miles
Publicado 2011

Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A(2A) Receptor crystals

por Rucktooa, Prakash, Cheng, Robert K. Y., Segala, Elena, Geng, Tian, Errey, James C., Brown, Giles A., Cooke, Robert M., Marshall, Fiona H., Doré, Andrew S.
Publicado 2018

Identification of Novel Adenosine A(2A) Receptor Antagonists by Virtual Screening

por Langmead, Christopher J., Andrews, Stephen P., Congreve, Miles, Errey, James C., Hurrell, Edward, Marshall, Fiona H., Mason, Jonathan S., Richardson, Christine M., Robertson, Nathan, Zhukov, Andrei, Weir, Malcolm
Publicado 2012

Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design

por Congreve, Miles, Andrews, Stephen P., Doré, Andrew S., Hollenstein, Kaspar, Hurrell, Edward, Langmead, Christopher J., Mason, Jonathan S., Ng, Irene W., Tehan, Benjamin, Zhukov, Andrei, Weir, Malcolm, Marshall, Fiona H.
Publicado 2012

Biophysical Fragment Screening of the β(1)-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

por Christopher, John A., Brown, Jason, Doré, Andrew S., Errey, James C., Koglin, Markus, Marshall, Fiona H., Myszka, David G., Rich, Rebecca L., Tate, Christopher G., Tehan, Benjamin, Warne, Tony, Congreve, Miles
Publicado 2013

Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M(1) receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending...

por Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Doll, Robert Jan, Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Publicado 2021

Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M(1)‐acetylcholine receptor agonist: A randomized cross‐over trial

por Bakker, Charlotte, Prins, Samantha, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Stevens, Jasper, Cross, David M., Tasker, Tim, Nathan, Pradeep J., Groeneveld, Geert Jan
Publicado 2021

First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M(1)‐receptor partial agonist for the treatment of dementias...

por Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Prins, Samantha, van der Doef, Thalia F., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Publicado 2021

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

por Heifetz, Alexander, Schertler, Gebhard F. X., Seifert, Roland, Tate, Christopher G., Sexton, Patrick M., Gurevich, Vsevolod V., Fourmy, Daniel, Cherezov, Vadim, Marshall, Fiona H., Storer, R. Ian, Moraes, Isabel, Tikhonova, Irina G., Tautermann, Christofer S., Hunt, Peter, Ceska, Tom, Hodgson, Simon, Bodkin, Mike J., Singh, Shweta, Law, Richard J., Biggin, Philip C.
Publicado 2015

Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis

por Rappas, Mathieu, Ali, Ammar A. E., Bennett, Kirstie A., Brown, Jason D., Bucknell, Sarah J., Congreve, Miles, Cooke, Robert M., Cseke, Gabriella, de Graaf, Chris, Doré, Andrew S., Errey, James C., Jazayeri, Ali, Marshall, Fiona H., Mason, Jonathan S., Mould, Richard, Patel, Jayesh C., Tehan, Benjamin G., Weir, Malcolm, Christopher, John A.
Publicado 2019