Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump

por Marshall, Robert L., Bavro, Vassiliy N.
Publicado 2020

Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies

por Symmons, Martyn F., Marshall, Robert L., Bavro, Vassiliy N.
Publicado 2015

Absence, loss-of-function, or inhibition of Escherichia coli AcrB does not increase expression of other efflux pump genes supporting the discovery of AcrB inhibitors as antibiotic...

por Ciusa, Maria Laura, Marshall, Robert L, Ricci, Vito, Stone, Jack W, Piddock, Laura J V
Publicado 2021

The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow‐growing mycobacteria

por Javid, Asma, Cooper, Charlotte, Singh, Albel, Schindler, Steffen, Hänisch, Milena, Marshall, Robert L., Kalscheuer, Rainer, Bavro, Vassiliy N., Bhatt, Apoorva
Publicado 2019

Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli

por Johnson, Matthew D, Bell, James, Clarke, Kim, Chandler, Rachel, Pathak, Prachi, Xia, Yandong, Marshall, Robert L, Weinstock, George M, Loman, Nicholas J, Winn, Peter J, Lund, Peter A
Publicado 2014

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

por Grimsey, Elizabeth M., Fais, Chiara, Marshall, Robert L., Ricci, Vito, Ciusa, Maria Laura, Stone, Jack W., Ivens, Alasdair, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Piddock, Laura J. V.
Publicado 2020

New Multidrug Efflux Inhibitors for Gram-Negative Bacteria

por Marshall, Robert L., Lloyd, Georgina S., Lawler, Amelia J., Element, Sarah J., Kaur, Jaswant, Ciusa, Maria Laura, Ricci, Vito, Tschumi, Andreas, Kühne, Holger, Alderwick, Luke J., Piddock, Laura J. V.
Publicado 2020

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella

por Johnson, Rachel M., Fais, Chiara, Parmar, Mayuriben, Cheruvara, Harish, Marshall, Robert L., Hesketh, Sophie J., Feasey, Matthew C., Ruggerone, Paolo, Vargiu, Attilio V., Postis, Vincent L. G., Muench, Stephen P., Bavro, Vassiliy N.
Publicado 2020