Why Is there a Limit to the Changes in Myofilament Ca(2+)-Sensitivity Associated with Myopathy Causing Mutations?

por Marston, Steven B.
Publicado 2016

The Importance of Intrinsically Disordered Segments of Cardiac Troponin in Modulating Function by Phosphorylation and Disease-Causing Mutations

por Papadaki, Maria, Marston, Steven B.
Publicado 2016

Back to the future: new techniques show that forgotten phosphorylation sites are present in contractile proteins of the heart whilst intensively studied sites appear to be absent

por Marston, Steven B., Walker, Jeffrey W.
Publicado 2009

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy

por Messer, Andrew E., Marston, Steven B.
Publicado 2014

Modulation of Structure and Dynamics of Cardiac Troponin by Phosphorylation and Mutations Revealed by Molecular Dynamics Simulations

por Yang, Zeyu, Marston, Steven B., Gould, Ian R.
Publicado 2023

Instrumentation to study myofibril mechanics from static to artificial simulations of cardiac cycle

por Vikhorev, Petr G., Ferenczi, Michael A., Marston, Steven B.
Publicado 2016

Approaches to High-Throughput Analysis of Cardiomyocyte Contractility

por Wright, Peter T., Tsui, Sharmane F., Francis, Alice J., MacLeod, Kenneth T., Marston, Steven B.
Publicado 2020

Investigations into the Sarcomeric Protein and Ca(2+)-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus)

por Messer, Andrew E., Chan, Jasmine, Daley, Alex, Copeland, O'Neal, Marston, Steven B., Connolly, David J.
Publicado 2017

The Dilated Cardiomyopathy-Causing Mutation ACTC E361G in Cardiac Muscle Myofibrils Specifically Abolishes Modulation of Ca(2+) Regulation by Phosphorylation of Troponin I

por Vikhorev, Petr G., Song, Weihua, Wilkinson, Ross, Copeland, O’Neal, Messer, Andrew E., Ferenczi, Michael A., Marston, Steven B.
Publicado 2014

Molecular Defects in Cardiac Myofilament Ca(2+)-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin

por Sheehan, Alice, Messer, Andrew E., Papadaki, Maria, Choudhry, Afnan, Kren, Vladimír, Biedermann, David, Blagg, Brian, Khandelwal, Anuj, Marston, Steven B.
Publicado 2018

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation()

por Messer, Andrew E., Bayliss, Christopher R., El-Mezgueldi, Mohammed, Redwood, Charles S., Ward, Douglas G., Leung, Man-Ching, Papadaki, Maria, dos Remedios, Cristobal, Marston, Steven B.
Publicado 2016

A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation

por Toepfer, Christopher N., Sikkel, Markus B., Caorsi, Valentina, Vydyanath, Anupama, Torre, Iratxe, Copeland, O'Neal, Lyon, Alexander R., Marston, Steven B., Luther, Pradeep K., Macleod, Kenneth T., West, Timothy G., Ferenczi, Michael A.
Publicado 2016

Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation

por Vikhorev, Petr G, Vikhoreva, Natalia N, Yeung, WaiChun, Li, Amy, Lal, Sean, dos Remedios, Cristobal G, Blair, Cheavar A, Guglin, Maya, Campbell, Kenneth S, Yacoub, Magdi H, de Tombe, Pieter, Marston, Steven B
Publicado 2020

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

por Toepfer, Christopher, Caorsi, Valentina, Kampourakis, Thomas, Sikkel, Markus B., West, Timothy G., Leung, Man-Ching, Al-Saud, Sara A., MacLeod, Kenneth T., Lyon, Alexander R., Marston, Steven B., Sellers, James R., Ferenczi, Michael A.
Publicado 2013

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

por Hoskins, Anita C., Jacques, Adam, Bardswell, Sonya C., McKenna, William J., Tsang, Victor, dos Remedios, Cristobal G., Ehler, Elisabeth, Adams, Kim, Jalilzadeh, Shapour, Avkiran, Metin, Watkins, Hugh, Redwood, Charles, Marston, Steven B., Kentish, Jonathan C.
Publicado 2010

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy

por Jacques, Adam M., Briceno, Natalia, Messer, Andrew E., Gallon, Clare E., Jalilzadeh, Shapour, Garcia, Edwin, Kikonda-Kanda, Gaelle, Goddard, Jennifer, Harding, Sian E., Watkins, Hugh, Esteban, M. Tomé, Tsang, Victor T., McKenna, William J., Marston, Steven B.
Publicado 2008

Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

por Vikhorev, Petr G., Smoktunowicz, Natalia, Munster, Alex B., Copeland, O’Neal, Kostin, Sawa, Montgiraud, Cecile, Messer, Andrew E., Toliat, Mohammad R., Li, Amy, dos Remedios, Cristobal G., Lal, Sean, Blair, Cheavar A., Campbell, Kenneth S., Guglin, Maya, Richter, Manfred, Knöll, Ralph, Marston, Steven B.
Publicado 2017

Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

por Vikhorev, Petr G., Smoktunowicz, Natalia, Munster, Alex B., Copeland, O’ Neal, Kostin, Sawa, Montgiraud, Cecile, Messer, Andrew E., Toliat, Mohammad R., Li, Amy, dos Remedios, Cristobal G., Lal, Sean, Blair, Cheavar A., Campbell, Kenneth S., Guglin, Maya, Richter, Manfred, Knöll, Ralph, Marston, Steven B.
Publicado 2018

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

por Piroddi, Nicoletta, Witjas-Paalberends, E. Rosalie, Ferrara, Claudia, Ferrantini, Cecilia, Vitale, Giulia, Scellini, Beatrice, Wijnker, Paul J.M., Sequiera, Vasco, Dooijes, Dennis, dos Remedios, Cristobal, Schlossarek, Saskia, Leung, Man Ching, Messer, Andrew, Ward, Douglas G., Biggeri, Annibale, Tesi, Chiara, Carrier, Lucie, Redwood, Charles S., Marston, Steven B., van der Velden, Jolanda, Poggesi, Corrado
Publicado 2019

Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics

por Tucholski, Trisha, Cai, Wenxuan, Gregorich, Zachery R., Bayne, Elizabeth F., Mitchell, Stanford D., McIlwain, Sean J., de Lange, Willem J., Wrobbel, Max, Karp, Hannah, Hite, Zachary, Vikhorev, Petr G., Marston, Steven B., Lal, Sean, Li, Amy, dos Remedios, Cristobal, Kohmoto, Takushi, Hermsen, Joshua, Ralphe, J. Carter, Kamp, Timothy J., Moss, Richard L., Ge, Ying
Publicado 2020