AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis

por Singh, Abhishek A., Mandoli, Amit, Prange, Koen H.M., Laakso, Marko, Martens, Joost H.A.
Publicado 2016

The AAA+ ATPase RUVBL2 is essential for the oncogenic function of c-MYB in acute myeloid leukemia

por Armenteros-Monterroso, Elena, Zhao, Lu, Gasparoli, Luca, Brooks, Tony, Pearce, Kerra, Mansour, Marc R., Martens, Joost H.A., de Boer, Jasper, Williams, Owen
Publicado 2019

P455: RUNX1 DIRECTLY BINDS AND REGULATES THE TCF4 PROMOTER

por Gerritsen, Mylene, in ‘t Hout, Florentien E.M., G.H.J.N. Knops, Ruth, van der Reijden, Bert A., Martens, Joost H.A., H Jansen, Joop
Publicado 2023

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

por Azkanaz, Maria, Rodríguez López, Aida, de Boer, Bauke, Huiting, Wouter, Angrand, Pierre-Olivier, Vellenga, Edo, Kampinga, Harm H, Bergink, Steven, Martens, Joost HA, Schuringa, Jan Jacob, van den Boom, Vincent
Publicado 2019

Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation

por Cieslak, Agata, Charbonnier, Guillaume, Tesio, Melania, Mathieu, Eve-Lyne, Belhocine, Mohamed, Touzart, Aurore, Smith, Charlotte, Hypolite, Guillaume, Andrieu, Guillaume P., Martens, Joost H.A., Janssen-Megens, Eva, Gut, Marta, Gut, Ivo, Boissel, Nicolas, Petit, Arnaud, Puthier, Denis, Macintyre, Elizabeth, Stunnenberg, Hendrik G., Spicuglia, Salvatore, Asnafi, Vahid
Publicado 2020

Dynamics of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes

por Belhocine, Mohamed, Simonin, Mathieu, Abad Flores, José David, Cieslak, Agata, Manosalva, Iris, Pradel, Lydie, Smith, Charlotte, Mathieu, Eve-Lyne, Charbonnier, Guillaume, Martens, Joost H.A., Stunnenberg, Hendrik G., Maqbool, Muhammad Ahmad, Mikulasova, Aneta, Russell, Lisa J., Rico, Daniel, Puthier, Denis, Ferrier, Pierre, Asnafi, Vahid, Spicuglia, Salvatore
Publicado 2022

The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

por Maat, Henny, Atsma, Tjerk Jan, Hogeling, Shanna M., Rodríguez López, Aida, Jaques, Jennifer, Olthuis, Mirjam, de Vries, Marcel P., Gravesteijn, Chantal, Brouwers-Vos, Annet Z., van der Meer, Nisha, Datema, Suzan, Salzbrunn, Jonas, Huls, Gerwin, Baas, Roy, Martens, Joost H.A., van den Boom, Vincent, Schuringa, Jan Jacob
Publicado 2021

Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems

por Schuyler, Ronald P., Merkel, Angelika, Raineri, Emanuele, Altucci, Lucia, Vellenga, Edo, Martens, Joost H.A., Pourfarzad, Farzin, Kuijpers, Taco W., Burden, Frances, Farrow, Samantha, Downes, Kate, Ouwehand, Willem H., Clarke, Laura, Datta, Avik, Lowy, Ernesto, Flicek, Paul, Frontini, Mattia, Stunnenberg, Hendrik G., Martín-Subero, José I., Gut, Ivo, Heath, Simon
Publicado 2016

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

por Novakovic, Boris, Habibi, Ehsan, Wang, Shuang-Yin, Arts, Rob J.W., Davar, Robab, Megchelenbrink, Wout, Kim, Bowon, Kuznetsova, Tatyana, Kox, Matthijs, Zwaag, Jelle, Matarese, Filomena, van Heeringen, Simon J., Janssen-Megens, Eva M., Sharifi, Nilofar, Wang, Cheng, Keramati, Farid, Schoonenberg, Vivien, Flicek, Paul, Clarke, Laura, Pickkers, Peter, Heath, Simon, Gut, Ivo, Netea, Mihai G., Martens, Joost H.A., Logie, Colin, Stunnenberg, Hendrik G.
Publicado 2016

eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

por Breeze, Charles E., Paul, Dirk S., van Dongen, Jenny, Butcher, Lee M., Ambrose, John C., Barrett, James E., Lowe, Robert, Rakyan, Vardhman K., Iotchkova, Valentina, Frontini, Mattia, Downes, Kate, Ouwehand, Willem H., Laperle, Jonathan, Jacques, Pierre-Étienne, Bourque, Guillaume, Bergmann, Anke K., Siebert, Reiner, Vellenga, Edo, Saeed, Sadia, Matarese, Filomena, Martens, Joost H.A., Stunnenberg, Hendrik G., Teschendorff, Andrew E., Herrero, Javier, Birney, Ewan, Dunham, Ian, Beck, Stephan
Publicado 2016

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

por Vierboom, Michel P.M., Dijkman, Karin, Sombroek, Claudia C., Hofman, Sam O., Boot, Charelle, Vervenne, Richard A.W., Haanstra, Krista G., van der Sande, Maarten, van Emst, Liesbeth, Domínguez-Andrés, Jorge, Moorlag, Simone J.C.F.M., Kocken, Clemens H.M., Thole, Jelle, Rodríguez, Esteban, Puentes, Eugenia, Martens, Joost H.A., van Crevel, Reinout, Netea, Mihai G., Aguilo, Nacho, Martin, Carlos, Verreck, Frank A.W.
Publicado 2021

Cell type-specific novel long non-coding RNA and circular RNA in the BLUEPRINT hematopoietic transcriptomes atlas

por Grassi, Luigi, Izuogu, Osagie G., Jorge, Natasha A.N., Seyres, Denis, Bustamante, Mariona, Burden, Frances, Farrow, Samantha, Farahi, Neda, Martin, Fergal J., Frankish, Adam, Mudge, Jonathan M., Kostadima, Myrto, Petersen, Romina, Lambourne, John J., Rowlston, Sophia, Martin-Rendon, Enca, Clarke, Laura, Downes, Kate, Estivill, Xavier, Flicek, Paul, Martens, Joost H.A., Yaspo, Marie-Laure, Stunnenberg, Hendrik G., Ouwehand, Willem H., Passetti, Fabio, Turro, Ernest, Frontini, Mattia
Publicado 2020

Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes

por Yi, Guoqiang, Wierenga, Albertus T.J., Petraglia, Francesca, Narang, Pankaj, Janssen-Megens, Eva M., Mandoli, Amit, Merkel, Angelika, Berentsen, Kim, Kim, Bowon, Matarese, Filomena, Singh, Abhishek A., Habibi, Ehsan, Prange, Koen H.M., Mulder, André B., Jansen, Joop H., Clarke, Laura, Heath, Simon, van der Reijden, Bert A., Flicek, Paul, Yaspo, Marie-Laure, Gut, Ivo, Bock, Christoph, Schuringa, Jan Jacob, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.
Publicado 2019

Molecular mechanisms of bleeding disorderassociated GFI1B(Q287*) mutation and its affected pathways in megakaryocytes and platelets

por van Oorschot, Rinske, Hansen, Marten, Koornneef, Johanna M., Marneth, Anna E., Bergevoet, Saskia M., van Bergen, Maaike G.J.M., van Alphen, Floris P.J., van der Zwaan, Carmen, Martens, Joost H.A., Vermeulen, Michiel, Jansen, Pascal W.T.C., Baltissen, Marijke P.A., Gorkom, Britta A.P. Laros-van, Janssen, Hans, Jansen, Joop H., von Lindern, Marieke, Meijer, Alexander B., van den Akker, Emile, van der Reijden, Bert A.
Publicado 2019

Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia

por Singh, Abhishek A., Petraglia, Francesca, Nebbioso, Angela, Yi, Guoqiang, Conte, Mariarosaria, Valente, Sergio, Mandoli, Amit, Scisciola, Lucia, Lindeboom, Rik, Kerstens, Hinri, Janssen-Megens, Eva M., Pourfarzad, Farzin, Habibi, Ehsan, Berentsen, Kim, Kim, Bowon, Logie, Colin, Heath, Simon, Wierenga, Albertus T.J., Clarke, Laura, Flicek, Paul, Jansen, Joop H., Kuijpers, Taco, Yaspo, Marie Laure, Valle, Veronique Della, Bernard, Olivier, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Altucci, Lucia, Martens, Joost H.A.
Publicado 2018

Combined HAT/EZH2 modulation leads to cancer-selective cell death

por Petraglia, Francesca, Singh, Abhishek A., Carafa, Vincenzo, Nebbioso, Angela, Conte, Mariarosaria, Scisciola, Lucia, Valente, Sergio, Baldi, Alfonso, Mandoli, Amit, Petrizzi, Valeria Belsito, Ingenito, Concetta, De Falco, Sandro, Cicatiello, Valeria, Apicella, Ivana, Janssen-Megens, Eva M., Kim, Bowon, Yi, Guoqiang, Logie, Colin, Heath, Simon, Ruvo, Menotti, Wierenga, Albertus T.J., Flicek, Paul, Yaspo, Marie Laure, Della Valle, Veronique, Bernard, Olivier, Tomassi, Stefano, Novellino, Ettore, Feoli, Alessandra, Sbardella, Gianluca, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Martens, Joost H.A., Altucci, Lucia
Publicado 2018

Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

por Grassi, Luigi, Pourfarzad, Farzin, Ullrich, Sebastian, Merkel, Angelika, Were, Felipe, Carrillo-de-Santa-Pau, Enrique, Yi, Guoqiang, Hiemstra, Ida H., Tool, Anton T.J., Mul, Erik, Perner, Juliane, Janssen-Megens, Eva, Berentsen, Kim, Kerstens, Hinri, Habibi, Ehsan, Gut, Marta, Yaspo, Marie Laure, Linser, Matthias, Lowy, Ernesto, Datta, Avik, Clarke, Laura, Flicek, Paul, Vingron, Martin, Roos, Dirk, van den Berg, Timo K., Heath, Simon, Rico, Daniel, Frontini, Mattia, Kostadima, Myrto, Gut, Ivo, Valencia, Alfonso, Ouwehand, Willem H., Stunnenberg, Hendrik G., Martens, Joost H.A., Kuijpers, Taco W.
Publicado 2018

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

por Agirre, Xabier, Castellano, Giancarlo, Pascual, Marien, Heath, Simon, Kulis, Marta, Segura, Victor, Bergmann, Anke, Esteve, Anna, Merkel, Angelika, Raineri, Emanuele, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Russiñol, Nuria, Queirós, Ana C., Beekman, Renée, Rodríguez-Madoz, Juan R., José-Enériz, Edurne San, Fang, Fang, Gutiérrez, Norma C., García-Verdugo, José M., Robson, Michael I., Schirmer, Eric C., Guruceaga, Elisabeth, Martens, Joost H.A., Gut, Marta, Calasanz, Maria J., Flicek, Paul, Siebert, Reiner, Campo, Elías, Miguel, Jesús F. San, Melnick, Ari, Stunnenberg, Hendrik G., Gut, Ivo G., Prosper, Felipe, Martín-Subero, José I.
Publicado 2015

The EHA Research Roadmap: Normal Hematopoiesis

por Jaffredo, Thierry, Balduini, Alessandra, Bigas, Anna, Bernardi, Rosa, Bonnet, Dominique, Canque, Bruno, Charbord, Pierre, Cumano, Anna, Delwel, Ruud, Durand, Charles, Fibbe, Willem, Forrester, Lesley, de Franceschi, Lucia, Ghevaert, Cedric, Gjertsen, Bjørn, Gottgens, Berthold, Graf, Thomas, Heidenreich, Olaf, Hermine, Olivier, Higgs, Douglas, Kleanthous, Marina, Klump, Hannes, Kouskoff, Valerie, Krause, Daniela, Lacaud, George, Celso, Cristina Lo, Martens, Joost H.A., Méndez-Ferrer, Simón, Menendez, Pablo, Oostendorp, Robert, Philipsen, Sjaak, Porse, Bo, Raaijmakers, Marc, Robin, Catherine, Stunnenberg, Henk, Theilgaard-Mönch, Kim, Touw, Ivo, Vainchenker, William, Corrons, Joan-Lluis Vives, Yvernogeau, Laurent, Schuringa, Jan Jacob
Publicado 2021

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

por Ordoñez, Raquel, Kulis, Marta, Russiñol, Nuria, Chapaprieta, Vicente, Carrasco-Leon, Arantxa, García-Torre, Beatriz, Charalampopoulou, Stella, Clot, Guillem, Beekman, Renée, Meydan, Cem, Duran-Ferrer, Martí, Verdaguer-Dot, Núria, Vilarrasa-Blasi, Roser, Soler-Vila, Paula, Garate, Leire, Miranda, Estíbaliz, San José-Enériz, Edurne, Rodriguez-Madoz, Juan R., Ezponda, Teresa, Martínez-Turrilas, Rebeca, Vilas-Zornoza, Amaia, Lara-Astiaso, David, Dupéré-Richer, Daphné, Martens, Joost H.A., El-Omri, Halima, Taha, Ruba Y., Calasanz, Maria J., Paiva, Bruno, San Miguel, Jesus, Flicek, Paul, Gut, Ivo, Melnick, Ari, Mitsiades, Constantine S., Licht, Jonathan D., Campo, Elias, Stunnenberg, Hendrik G., Agirre, Xabier, Prosper, Felipe, Martin-Subero, Jose I.
Publicado 2020