Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing

por Yamazaki, Akari, Shue, Francis, Yamazaki, Yu, Martens, Yuka A., Bu, Guojun, Liu, Chia-Chen
Publicado 2021

Generation and validation of APOE knockout human iPSC-derived cerebral organoids

por Martens, Yuka A., Xu, Siming, Tait, Richard, Li, Gary, Zhao, Xinping C., Lu, Wenyan, Liu, Chia-Chen, Kanekiyo, Takahisa, Bu, Guojun, Zhao, Jing
Publicado 2021

Standardized immunoprecipitation protocol for efficient isolation of native apolipoprotein E particles utilizing HJ15.4 monoclonal antibody

por O’Leary, Justin, Raulin, Ana-Caroline, Li, Zonghua, Martens, Yuka, Inoue, Yasuteru, Strickland, Michael R., Han, Xianlin, Holtzman, David M., Bu, Guojun, Zhao, Na
Publicado 2023

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

por Zhong, Li, Wang, Zongqi, Wang, Daxin, Wang, Zhe, Martens, Yuka A., Wu, Linbei, Xu, Ying, Wang, Kai, Li, Jianguo, Huang, Ruizhi, Can, Dan, Xu, Huaxi, Bu, Guojun, Chen, Xiao-Fen
Publicado 2018

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

por Zhao, Jing, Ikezu, Tadafumi C., Lu, Wenyan, Macyczko, Jesse R., Li, Yonghe, Lewis-Tuffin, Laura J., Martens, Yuka A., Ren, Yingxue, Zhu, Yiyang, Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun
Publicado 2023

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

por Wang, Na, Wang, Minghui, Jeevaratnam, Suren, Rosenberg, Cassandra, Ikezu, Tadafumi C., Shue, Francis, Doss, Sydney V., Alnobani, Alla, Martens, Yuka A., Wren, Melissa, Asmann, Yan W., Zhang, Bin, Bu, Guojun, Liu, Chia-Chen
Publicado 2022

Sex specific molecular networks and key drivers of Alzheimer’s disease

por Guo, Lei, Cao, Jiqing, Hou, Jianwei, Li, Yonghe, Huang, Min, Zhu, Li, Zhang, Larry, Lee, Yeji, Duarte, Mariana Lemos, Zhou, Xianxiao, Wang, Minghui, Liu, Chia-Chen, Martens, Yuka, Chao, Michael, Goate, Alison, Bu, Guojun, Haroutunian, Vahram, Cai, Dongming, Zhang, Bin
Publicado 2023

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

por Xie, Manling, Liu, Yong U., Zhao, Shunyi, Zhang, Lingxin, Bosco, Dale B., Pang, Yuan-Ping, Zhong, Jun, Sheth, Udit, Martens, Yuka A., Zhao, Na, Liu, Chia-Chen, Zhuang, Yongxian, Wang, Liewei, Dickson, Dennis W., Mattson, Mark P., Bu, Guojun, Wu, Long-Jun
Publicado 2021

LRP1 is a neuronal receptor for α-synuclein uptake and spread

por Chen, Kai, Martens, Yuka A., Meneses, Axel, Ryu, Daniel H., Lu, Wenyan, Raulin, Ana Caroline, Li, Fuyao, Zhao, Jing, Chen, Yixing, Jin, Yunjung, Linares, Cynthia, Goodwin, Marshall, Li, Yonghe, Liu, Chia-Chen, Kanekiyo, Takahisa, Holtzman, David M., Golde, Todd E., Bu, Guojun, Zhao, Na
Publicado 2022

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

por Jin, Yunjung, Li, Fuyao, Sonoustoun, Berkiye, Kondru, Naveen Chandra, Martens, Yuka A., Qiao, Wenhui, Heckman, Michael G., Ikezu, Tadafumi C., Li, Zonghua, Burgess, Jeremy D., Amerna, Danilyn, O’Leary, Justin, DeTure, Michael A., Zhao, Jing, McLean, Pamela J., Dickson, Dennis W., Ross, Owen A., Bu, Guojun, Zhao, Na
Publicado 2022

Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

por Qiao, Wenhui, Chen, Yixing, Zhong, Jun, Madden, Benjamin J., Charlesworth, Cristine M., Martens, Yuka A., Liu, Chia-Chen, Knight, Joshua, Ikezu, Tadafumi C., Kurti, Aishe, Zhu, Yiyang, Meneses, Axel, Rosenberg, Cassandra L., Kuchenbecker, Lindsey A., Vanmaele, Lucy K., Li, Fuyao, Chen, Kai, Shue, Francis, Dacquel, Maxwell V., Fryer, John, Pandey, Akhilesh, Zhao, Na, Bu, Guojun
Publicado 2023

Association study between multiple system atrophy and TREM2 p.R47H

por Ogaki, Kotaro, Heckman, Michael G., Koga, Shunsuke, Martens, Yuka A., Labbé, Catherine, Lorenzo-Betancor, Oswaldo, Walton, Ronald L., Soto, Alexandra I., Vargas, Emily R., Fujioka, Shinsuke, Uitti, Ryan J., van Gerpen, Jay A., Cheshire, William P., Younkin, Steven G., Wszolek, Zbigniew K., Low, Phillip A., Singer, Wolfgang, Bu, Guojun, Dickson, Dennis W., Ross, Owen A.
Publicado 2018

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

por Qiao, Wenhui, Chen, Yixing, Zhong, Jun, Madden, Benjamin J., Charlesworth, Cristine M., Martens, Yuka A., Liu, Chia-Chen, Knight, Joshua, Ikezu, Tadafumi C., Kurti, Aishe, Zhu, Yiyang, Meneses, Axel, Rosenberg, Cassandra L., Kuchenbecker, Lindsey A., Vanmaele, Lucy K., Li, Fuyao, Chen, Kai, Shue, Francis, Dacquel, Maxwell V., Fryer, John, Pandey, Akhilesh, Zhao, Na, Bu, Guojun
Publicado 2023

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

por Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun
Publicado 2020

Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

por Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun
Publicado 2021

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

por Zhao, Jing, Lu, Wenyan, Ren, Yingxue, Fu, Yuan, Martens, Yuka A., Shue, Francis, Davis, Mary D., Wang, Xue, Chen, Kai, Li, Fuyao, Liu, Chia-Chen, Graff-Radford, Neill R., Wszolek, Zbigniew K., Younkin, Steven G., Brafman, David A., Ertekin-Taner, Nilüfer, Asmann, Yan W., Dickson, Dennis W., Xu, Ziying, Pan, Meixia, Han, Xianlin, Kanekiyo, Takahisa, Bu, Guojun
Publicado 2021

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

por Oatman, Stephanie R., Reddy, Joseph S., Quicksall, Zachary, Carrasquillo, Minerva M., Wang, Xue, Liu, Chia-Chen, Yamazaki, Yu, Nguyen, Thuy T., Malphrus, Kimberly, Heckman, Michael, Biswas, Kristi, Nho, Kwangsik, Baker, Matthew, Martens, Yuka A., Zhao, Na, Kim, Jun Pyo, Risacher, Shannon L., Rademakers, Rosa, Saykin, Andrew J., DeTure, Michael, Murray, Melissa E., Kanekiyo, Takahisa, Dickson, Dennis W., Bu, Guojun, Allen, Mariet, Ertekin-Taner, Nilüfer
Publicado 2023

APOE ε2 is associated with increased tau pathology in primary tauopathy

por Zhao, Na, Liu, Chia-Chen, Van Ingelgom, Alexandra J., Linares, Cynthia, Kurti, Aishe, Knight, Joshua A., Heckman, Michael G., Diehl, Nancy N., Shinohara, Mitsuru, Martens, Yuka A., Attrebi, Olivia N., Petrucelli, Leonard, Fryer, John D., Wszolek, Zbigniew K., Graff-Radford, Neill R., Caselli, Richard J., Sanchez-Contreras, Monica Y., Rademakers, Rosa, Murray, Melissa E., Koga, Shunsuke, Dickson, Dennis W., Ross, Owen A., Bu, Guojun
Publicado 2018

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease

por Liu, Chia-Chen, Yamazaki, Yu, Heckman, Michael G., Martens, Yuka A., Jia, Lin, Yamazaki, Akari, Diehl, Nancy N., Zhao, Jing, Zhao, Na, DeTure, Michael, Davis, Mary D., Felton, Lindsey M., Qiao, Wenhui, Li, Yonghe, Li, Hongmei, Fu, Yuan, Wang, Na, Wren, Melissa, Aikawa, Tomonori, Holm, Marie-Louise, Oue, Hiroshi, Linares, Cynthia, Allen, Mariet, Carrasquillo, Minerva M., Murray, Melissa E., Petersen, Ronald C., Ertekin-Taner, Nilüfer, Dickson, Dennis W., Kanekiyo, Takahisa, Bu, Guojun
Publicado 2020

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia

por Zhao, Na, Qiao, Wenhui, Li, Fuyao, Ren, Yingxue, Zheng, Jiaying, Martens, Yuka A., Wang, Xusheng, Li, Ling, Liu, Chia-Chen, Chen, Kai, Zhu, Yiyang, Ikezu, Tadafumi C., Li, Zonghua, Meneses, Axel D., Jin, Yunjung, Knight, Joshua A., Chen, Yixing, Bastea, Ligia, Linares, Cynthia, Sonustun, Berkiye, Job, Lucy, Smith, Madeleine L., Xie, Manling, Liu, Yong U., Umpierre, Anthony D., Haruwaka, Koichiro, Quicksall, Zachary S., Storz, Peter, Asmann, Yan W., Wu, Long-Jun, Bu, Guojun
Publicado 2022