Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer

por Weigel, Marion T, Ghazoui, Zara, Dunbier, Anita, Pancholi, Sunil, Dowsett, Mitch, Martin, Lesley-Ann
Publicado 2012

Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts

por Andreucci, Elena, Francica, Paola, Fearns, Antony, Martin, Lesley-Ann, Chiarugi, Paola, Isacke, Clare M., Morandi, Andrea
Publicado 2016

Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers

por Ribas, Ricardo, Ghazoui, Zara, Gao, Qiong, Pancholi, Sunil, Rani, Aradhana, Dunbier, Anita, Dowsett, Mitch, Martin, Lesley-Ann
Publicado 2014

Src Is a Potential Therapeutic Target in Endocrine-Resistant Breast Cancer Exhibiting Low Estrogen Receptor-Mediated Transactivation

por Guest, Stephanie K., Ribas, Ricardo, Pancholi, Sunil, Nikitorowicz-Buniak, Joanna, Simigdala, Nikiana, Dowsett, Mitch, Johnston, Stephen R., Martin, Lesley-Ann
Publicado 2016

Relationship of PIK3CA mutation and pathway activity with antiproliferative response to aromatase inhibition

por López-Knowles, Elena, Segal, Corrinne V, Gao, Qiong, Garcia-Murillas, Isaac, Turner, Nicholas C, Smith, Ian, Martin, Lesley-Ann, Dowsett, Mitch
Publicado 2014

Abiraterone shows alternate activity in models of endocrine resistant and sensitive disease

por Simigdala, Nikiana, Pancholi, Sunil, Ribas, Ricardo, Folkerd, Elizabeth, Liccardi, Gianmaria, Nikitorowicz-Buniak, Joanna, Johnston, Stephen R., Dowsett, Mitch, Martin, Lesley-Ann
Publicado 2018

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

por Simigdala, Nikiana, Gao, Qiong, Pancholi, Sunil, Roberg-Larsen, Hanne, Zvelebil, Marketa, Ribas, Ricardo, Folkerd, Elizabeth, Thompson, Andrew, Bhamra, Amandeep, Dowsett, Mitch, Martin, Lesley-Ann
Publicado 2016

ESR1 Is Co-Expressed with Closely Adjacent Uncharacterised Genes Spanning a Breast Cancer Susceptibility Locus at 6q25.1

por Dunbier, Anita K., Anderson, Helen, Ghazoui, Zara, Lopez-Knowles, Elena, Pancholi, Sunil, Ribas, Ricardo, Drury, Suzanne, Sidhu, Kally, Leary, Alexandra, Martin, Lesley-Ann, Dowsett, Mitch
Publicado 2011

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

por Sava, Georgina P., Fan, Hailing, Fisher, Rosemary A., Lusvarghi, Sabrina, Pancholi, Sunil, Ambudkar, Suresh V., Martin, Lesley-Ann, Charles Coombes, R., Buluwela, Lakjaya, Ali, Simak
Publicado 2019

Elacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer

por Pancholi, Sunil, Simigdala, Nikiana, Ribas, Ricardo, Schuster, Eugene, Leal, Mariana Ferreira, Nikitorowicz-Buniak, Joanna, Rega, Camilla, Bihani, Teeru, Patel, Hitisha, Johnston, Stephen R., Dowsett, Mitch, Martin, Lesley-Ann
Publicado 2022

Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations

por Lopez-Knowles, Elena, Pearson, Alex, Schuster, Gene, Gellert, Pascal, Ribas, Ricardo, Yeo, Belinda, Cutts, Ros, Buus, Richard, Garcia-Murillas, Isaac, Haynes, Ben, Martin, Lesley-Ann, Smith, Ian, Turner, Nick, Dowsett, Mitch
Publicado 2018

Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo

por Martin, Lesley-Ann, Pancholi, Sunil, Farmer, Ian, Guest, Stephanie, Ribas, Ricardo, Weigel, Marion T, Thornhill, Allan M, Ghazoui, Zara, A'Hern, Roger, Evans, Dean B, Lane, Heidi A, Johnston, Stephen R, Dowsett, Mitch
Publicado 2012

Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer

por Ribas, Ricardo, Pancholi, Sunil, Rani, Aradhana, Schuster, Eugene, Guest, Stephanie K., Nikitorowicz-Buniak, Joanna, Simigdala, Nikiana, Thornhill, Allan, Avogadri-Connors, Francesca, Cutler, Richard E., Lalani, Alshad S., Dowsett, Mitch, Johnston, Stephen R., Martin, Lesley-Ann
Publicado 2018

Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

por Pancholi, Sunil, Leal, Mariana Ferreira, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Chateau-Joubert, Sophie, Zabaglo, Lila, Hills, Margaret, Dodson, Andrew, Gao, Qiong, Johnston, Stephen R., Dowsett, Mitch, Cosulich, Sabina C., Maragoni, Elisabetta, Martin, Lesley-Ann
Publicado 2019

Correction to: Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

por Pancholi, Sunil, Leal, Mariana Ferreira, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Chateau-Joubert, Sophie, Zabaglo, Lila, Hills, Margaret, Dodson, Andrew, Gao, Qiong, Johnston, Stephen R., Dowsett, Mitch, Cosulich, Sabina C., Marangoni, Elisabetta, Martin, Lesley-Ann
Publicado 2020

Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer

por López-Knowles, Elena, Wilkerson, Paul M, Ribas, Ricardo, Anderson, Helen, Mackay, Alan, Ghazoui, Zara, Rani, Aradhana, Osin, Peter, Nerurkar, Ash, Renshaw, Lorna, Larionov, Alexey, Miller, William R, Dixon, J Michael, Reis-Filho, Jorge S, Dunbier, Anita K, Martin, Lesley-Ann, Dowsett, Mitch
Publicado 2015

Capture Hi-C identifies putative target genes at 33 breast cancer risk loci

por Baxter, Joseph S., Leavy, Olivia C., Dryden, Nicola H., Maguire, Sarah, Johnson, Nichola, Fedele, Vita, Simigdala, Nikiana, Martin, Lesley-Ann, Andrews, Simon, Wingett, Steven W., Assiotis, Ioannis, Fenwick, Kerry, Chauhan, Ritika, Rust, Alistair G., Orr, Nick, Dudbridge, Frank, Haider, Syed, Fletcher, Olivia
Publicado 2018

Major Impact of Sampling Methodology on Gene Expression in Estrogen Receptor–Positive Breast Cancer

por Gao, Qiong, López-Knowles, Elena, U Cheang, Maggie Chon, Morden, James, Ribas, Ricardo, Sidhu, Kally, Evans, David, Martins, Vera, Dodson, Andrew, Skene, Anthony, Holcombe, Chris, Mallon, Elizabeth, Evans, Abigail, Bliss, Judith M, Robertson, John, Smith, Ian, Martin, Lesley-Ann, Dowsett, Mitch
Publicado 2018

Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients

por Gao, Qiong, López-Knowles, Elena, Cheang, Maggie Chon U., Morden, James, Ribas, Ricardo, Sidhu, Kally, Evans, David, Martins, Vera, Dodson, Andrew, Skene, Anthony, Holcombe, Chris, Mallon, Elizabeth, Evans, Abigail, Bliss, Judith M., Robertson, John, Smith, Ian, Martin, Lesley-Ann, Dowsett, Mitch
Publicado 2019

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

por Bacci, Marina, Lorito, Nicla, Ippolito, Luigi, Ramazzotti, Matteo, Luti, Simone, Romagnoli, Simone, Parri, Matteo, Bianchini, Francesca, Cappellesso, Federica, Virga, Federico, Gao, Qiong, Simões, Bruno M., Marangoni, Elisabetta, Martin, Lesley-Ann, Comito, Giuseppina, Ferracin, Manuela, Giannoni, Elisa, Mazzone, Massimiliano, Chiarugi, Paola, Morandi, Andrea
Publicado 2019