TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer’s Disease Patients

por Cuevas, Eva P., Rodríguez-Fernández, Alberto, Palomo, Valle, Martínez, Ana, Martín-Requero, Ángeles
Publicado 2022

Calmodulin levels in blood cells as a potential biomarker of Alzheimer’s disease

por Esteras, Noemí, Alquézar, Carolina, de la Encarnación, Ana, Villarejo, Alberto, Bermejo-Pareja, Félix, Martín-Requero, Ángeles
Publicado 2013

Inactivation of CDK/pRb Pathway Normalizes Survival Pattern of Lymphoblasts Expressing the FTLD-Progranulin Mutation c.709-1G>A

por Alquezar, Carolina, Esteras, Noemí, Alzualde, Ainhoa, Moreno, Fermín, Ayuso, Matilde S., López de Munain, Adolfo, Martín-Requero, Ángeles
Publicado 2012

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts

por Porras, Gracia, Ruiz, Silvana, Maestro, Inés, Borrego-Hernández, Daniel, Redondo, Alberto G., Martínez, Ana, Martín-Requero, Ángeles
Publicado 2023

Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants

por Wojsiat, Joanna, Laskowska-Kaszub, Katarzyna, Alquézar, Carolina, Białopiotrowicz, Emilia, Esteras, Noemi, Zdioruk, Mykola, Martin-Requero, Angeles, Wojda, Urszula
Publicado 2016

CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing

por Tosat-Bitrián, Carlota, Avis-Bodas, Alicia, Porras, Gracia, Borrego-Hernández, Daniel, García-Redondo, Alberto, Martín-Requero, Angeles, Palomo, Valle
Publicado 2021

Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis

por Martínez-González, Loreto, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Porras, Gracia, de Lago, Eva, Martín-Requero, Ángeles, Martínez, Ana
Publicado 2021

TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients

por Martinez-Gonzalez, Loreto, Cuevas, Eva P., Tosat-Bitrián, Carlota, Nozal, Vanesa, Gil, Carmen, Palomo, Valle, Martín-Requero, Ángeles, Martinez, Ana
Publicado 2023

Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer’s Disease Patients

por Cosín-Tomàs, Marta, Senserrich, Júlia, Arumí-Planas, Marta, Alquézar, Carolina, Pallàs, Mercè, Martín-Requero, Ángeles, Suñol, Cristina, Kaliman, Perla, Sanfeliu, Coral
Publicado 2019

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

por Rodríguez-Periñán, Guiomar, de la Encarnación, Ana, Moreno, Fermín, López de Munain, Adolfo, Martínez, Ana, Martín-Requero, Ángeles, Alquézar, Carolina, Bartolomé, Fernando
Publicado 2023

Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia

por Alquezar, Carolina, Salado, Irene G., de la Encarnación, Ana, Pérez, Daniel I., Moreno, Fermín, Gil, Carmen, de Munain, Adolfo López, Martínez, Ana, Martín-Requero, Ángeles
Publicado 2016

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

por Lastres-Becker, Isabel, Porras, Gracia, Arribas-Blázquez, Marina, Maestro, Inés, Borrego-Hernández, Daniel, Boya, Patricia, Cerdán, Sebastián, García-Redondo, Alberto, Martínez, Ana, Martin-Requero, Ángeles
Publicado 2021

Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation

por González-Jiménez, Adela, López-Cotarelo, Pilar, Agudo-Jiménez, Teresa, Casanova, Ignacio, de Silanes, Carlos López, Martín-Requero, Ángeles, Matesanz, Fuencisla, Urcelay, Elena, Espino-Paisán, Laura
Publicado 2022

Multitarget drugs as potential therapeutic agents for alzheimer’s disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors

por González-Naranjo, Pedro, Pérez, Concepción, González-Sánchez, Marina, Gironda-Martínez, Adrián, Ulzurrun, Eugenia, Bartolomé, Fernando, Rubio-Fernández, Marcos, Martin-Requero, Angeles, Campillo, Nuria E., Páez, Juan A.
Publicado 2022

Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment

por Martínez-González, Loreto, Rodríguez-Cueto, Carmen, Cabezudo, Diego, Bartolomé, Fernando, Andrés-Benito, Pol, Ferrer, Isidro, Gil, Carmen, Martín-Requero, Ángeles, Fernández-Ruiz, Javier, Martínez, Ana, de Lago, Eva
Publicado 2020

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

por Martín-Cámara, Olmo, Arribas, Marina, Wells, Geoffrey, Morales-Tenorio, Marcos, Martín-Requero, Ángeles, Porras, Gracia, Martínez, Ana, Giorgi, Giorgio, López-Alvarado, Pilar, Lastres-Becker, Isabel, Menéndez, J. Carlos
Publicado 2022

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

por Bartolome, Fernando, Esteras, Noemi, Martin-Requero, Angeles, Boutoleau-Bretonniere, Claire, Vercelletto, Martine, Gabelle, Audrey, Le Ber, Isabelle, Honda, Tadashi, Dinkova-Kostova, Albena T., Hardy, John, Carro, Eva, Abramov, Andrey Y.
Publicado 2017

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

por Bartolome, Fernando, Esteras, Noemi, Martin-Requero, Angeles, Boutoleau-Bretonniere, Claire, Vercelletto, Martine, Gabelle, Audrey, Ber, Isabelle Le, Honda, Tadashi, Dinkova-Kostova, Albena T., Hardy, John, Carro, Eva, Abramov, Andrey Y.
Publicado 2018