GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice

por Chen, Huazhen, Kevala, Karl, Aflaki, Elma, Marugan, Juan, Kim, Hee-Yong
Publicado 2021

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington’s Disease Model

por Titus, Steven A, Southall, Noel, Marugan, Juan, Austin, Christopher P, Zheng, Wei
Publicado 2012

Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury

por Kwon, Heungsun, Kevala, Karl, Xin, Hu, Patnaik, Samarjit, Marugan, Juan, Kim, Hee-Yong
Publicado 2021

High Throughput Screening for Inhibitors of Alpha-Galactosidase

por Motabar, Omid, Liu, Ke, Southall, Noel, Marugan, Juan J, Goldin, Ehud, Sidransky, Ellen, Zheng, Wei
Publicado 2010

Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction

por Ng, Hooi Hooi, Soula, Mariluz, Rivas, Bryan, Wilson, Kenneth J., Marugan, Juan J., Agoulnik, Alexander I.
Publicado 2021

Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury

por Kwon, Heung-Sun, Kevala, Karl, Qian, Haohua, Abu-Asab, Mones, Patnaik, Samarjit, Marugan, Juan, Kim, Hee-Yong
Publicado 2023

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

por Goldin, Ehud, Zheng, Wei, Motabar, Omid, Southall, Noel, Choi, Jae Hyuk, Marugan, Juan, Austin, Christopher P., Sidransky, Ellen
Publicado 2012

Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice

por Baxter, Laura L., Marugan, Juan J., Xiao, Jingbo, Incao, Art, McKew, John C., Zheng, Wei, Pavan, William J.
Publicado 2012

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

por Clarke, Jonathan H., Giudici, Maria-Luisa, Burke, John E., Williams, Roger L., Maloney, David J., Marugan, Juan, Irvine, Robin F.
Publicado 2015

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

por Huang, Bill X., Hu, Xin, Kwon, Heung-Sun, Fu, Cheng, Lee, Ji-Won, Southall, Noel, Marugan, Juan, Kim, Hee-Yong
Publicado 2020

Novel Patient Cell-Based HTS Assay for Identification of Small Molecules for a Lysosomal Storage Disease

por Geng, Haifeng, Whiteley, Grace, Ribbens, Jameson, Zheng, Wei, Southall, Noel, Hu, Xin, Marugan, Juan J., Ferrer, Marc, Maegawa, Gustavo H. B.
Publicado 2011

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK

por Dai, Sheng, Dulcey, Andrés E., Hu, Xin, Wassif, Christopher A., Porter, Forbes D., Austin, Christopher P., Ory, Daniel S., Marugan, Juan, Zheng, Wei
Publicado 2017

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

por Hu, Xin, Morazzani, Elaine, Compton, Jaimee R., Harmon, Moeshia, Soloveva, Veronica, Glass, Pamela J., Garcia, Andres Dulcey, Marugan, Juan J., Legler, Patricia M.
Publicado 2023

A Homogenous Luminescence Assay Reveals Novel Inhibitors for Giardia Lamblia Carbamate Kinase

por Chen, Catherine Z, Southall, Noel, Galkin, Andrey, Lim, Kap, Marugan, Juan J, Kulakova, Liudmila, Shinn, Paul, van Leer, Danielle, Zheng, Wei, Herzberg, Osnat
Publicado 2012

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function

por Lee, Ji-Won, Huang, Bill X., Kwon, HeungSun, Rashid, Md Abdur, Kharebava, Giorgi, Desai, Abhishek, Patnaik, Samarjit, Marugan, Juan, Kim, Hee-Yong
Publicado 2016

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt

por Huang, Bill X., Newcomer, Kenny, Kevala, Karl, Barnaeva, Elena, Zheng, Wei, Hu, Xin, Patnaik, Samarjit, Southall, Noel, Marugan, Juan, Ferrer, Marc, Kim, Hee-Yong
Publicado 2017

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

por Sima, Ni, Li, Rong, Huang, Wei, Xu, Miao, Beers, Jeanette, Zou, Jizhong, Titus, Steven, Ottinger, Elizabeth A., Marugan, Juan J., Xie, Xing, Zheng, Wei
Publicado 2018

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

por Aflaki, Elma, Moaven, Nima, Borger, Daniel K., Lopez, Grisel, Westbroek, Wendy, Chae, Jae Jin, Marugan, Juan, Patnaik, Samarjit, Maniwang, Emerson, Gonzalez, Ashley N., Sidransky, Ellen
Publicado 2015

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells

por Li, Rong, Hao, Jon, Fujiwara, Hideji, Xu, Miao, Yang, Shu, Dai, Sheng, Long, Yan, Swaroop, Manju, Li, Changhui, Vu, Mylinh, Marugan, Juan J., Ory, Daniel S., Zheng, Wei
Publicado 2017

Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290

por Kaftanovskaya, Elena M., Soula, Mariluz, Myhr, Courtney, Ho, Brian A., Moore, Stefanie N., Yoo, Changwon, Cervantes, Briana, How, Javier, Marugan, Juan, Agoulnik, Irina U., Agoulnik, Alexander I.
Publicado 2017