2-Morpholino-4-oxo-4,5-dihydro­thio­phene-3-carbonitrile

por Zhu, JinJiang, Liu, Kevin K., Marx, Matthew A., Rheingold, Arnold L., Yanovsky, Alex
Publicado 2009

Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted (19)F NMR Spectroscopy

por Kulyk, Svitlana, De Paul, Susan M., Marx, Matthew A., Peakman, Torren M., Smith, Christopher R.
Publicado 2022

Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free–Wilson Analysis for Improved In Vivo Efficacy

por Murphy, Sean T., Atienza, Joy, Brown, Jason W., Cheruvallath, Zacharia S., Cukierski, Matthew J., Fabrey, Robyn, Keung, Walter, Kwok, Lily, O’Connell, Shawn, Tang, Mingnam, Vanderpool, Darin L., Vincent, Patrick W., Zhang, Lilly, Marx, Matthew A.
Publicado 2023

Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits

por Smith, Christopher R., Kulyk, Svitlana, Ahmad, Misbha Ud Din, Arkhipova, Valentina, Christensen, James G., Gunn, Robin J., Ivetac, Anthony, Ketcham, John M., Kuehler, Jon, Lawson, J. David, Thomas, Nicole C., Wang, Xiaolun, Marx, Matthew A.
Publicado 2022

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

por Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.
Publicado 2022

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

por Engstrom, Lars D., Aranda, Ruth, Waters, Laura, Moya, Krystal, Bowcut, Vickie, Vegar, Laura, Trinh, David, Hebbert, Allan, Smith, Christopher R., Kulyk, Svitlana, Lawson, J. David, He, Leo, Hover, Laura D., Fernandez-Banet, Julio, Hallin, Jill, Vanderpool, Darin, Briere, David M., Blaj, Alice, Marx, Matthew A., Rodon, Jordi, Offin, Michael, Arbour, Kathryn C., Johnson, Melissa L., Kwiatkowski, David J., Jänne, Pasi A., Haddox, Candace L., Papadopoulos, Kyriakos P., Henry, Jason T., Leventakos, Konstantinos, Christensen, James G., Shazer, Ronald, Olson, Peter
Publicado 2023