The discovery and characterization of novel soluble guanylate cyclase stimulators

por Masferrer, Jaime L
Publicado 2015

pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

por Zhu, Ming, Pleasic-Williams, Susan, Lin, Tsung H, Wunderlich, David A, Cheng, John B, Masferrer, Jaime L
Publicado 2013

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes

por Ge, Pei, Navarro, Iris D., Kessler, Marco M., Bernier, Sylvie G., Perl, Nicholas R., Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W. Daniel
Publicado 2016

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH

por Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.
Publicado 2019

IWP-121: a novel sGC stimulator that reduces blood pressure and exhibits anti-fibrotic and anti-inflammatory activities in the Dahl Salt-Sensitive rat model

por Shea, Courtney, Ranganath, Sheila, Liu, Guang, Wachtel, Derek, Germano, Peter, Tobin, Jenny, Zhang, Ping, Rivers, Samuel, Im, G-Yoon Jamie, Sheppeck, James, Masferrer, Jaime
Publicado 2015

SGLT2 inhibition potentiates the cardiovascular, renal, and metabolic effects of sGC stimulation in hypertensive rats with prolonged exposure to high-fat diet

por Reverte, Virginia, Rodriguez, Francisca, Oltra, Lidia, Moreno, Juan M., Llinás, María T., Shea, Courtney M., Schwartzkopf, Chad D., Buys, Emmanuel S., Masferrer, Jaime L., Salazar, F. Javier
Publicado 2022

Concomitant administration of sGC stimulators with common classes of anti-hypertensive agents results in increased efficacy in spontaneously hypertensive rats

por Germano, Peter, Tobin, Jenny, Jefferson, Robert, Shea, Courtney, Smith, Adaline, Jamie Im, G-Yoon, Sheppeck, James, Wakefield, James, Sykes, Kristie, Ribadeneira, Maria, Rivers, Samuel, Masferrer, Jaime
Publicado 2015

Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit

por Flores-Costa, Roger, Duran-Güell, Marta, Casulleras, Mireia, López-Vicario, Cristina, Alcaraz-Quiles, José, Diaz, Alba, Lozano, Juan J., Titos, Esther, Hall, Katherine, Sarno, Renee, Masferrer, Jaime L., Clària, Joan
Publicado 2020

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

por Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Publicado 2020

The soluble guanylate cyclase stimulator IW‐1973 prevents inflammation and fibrosis in experimental non‐alcoholic steatohepatitis

por Flores‐Costa, Roger, Alcaraz‐Quiles, José, Titos, Esther, López‐Vicario, Cristina, Casulleras, Mireia, Duran‐Güell, Marta, Rius, Bibiana, Diaz, Alba, Hall, Katherine, Shea, Courtney, Sarno, Renee, Currie, Mark, Masferrer, Jaime L, Clària, Joan
Publicado 2018

Multiplex transcriptional analysis of paraffin-embedded liver needle biopsy from patients with liver fibrosis

por Staten, Nicholas R, Welsh, Eric A, Sidik, Kurex, McDonald, Sandra A, Dufield, Dawn R, Maqsodi, Botoul, Ma, Yunqing, McMaster, Gary K, Mathews, Rodney W, Arch, Robert H, Masferrer, Jaime L, Souberbielle, Bernard E
Publicado 2012

Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease

por Tchernychev, Boris, Li, Huihui, Lee, Sung‐Kyun, Gao, Xin, Ramanarasimhaiah, Raghunath, Liu, Guang, Hall, Katherine C., Bernier, Sylvie G., Jones, Juli E., Feil, Susanne, Feil, Robert, Buys, Emmanuel S., Graul, Regina M., Frenette, Paul S., Masferrer, Jaime L.
Publicado 2021

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

por Zimmer, Daniel P., Shea, Courtney M., Tobin, Jenny V., Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R., Jacobson, Sarah, Bernier, Sylvie G., Sarno, Renee, Carvalho, Andrew, Chien, Yueh-tyng, Graul, Regina, Buys, Emmanuel S., Jones, Juli E., Wakefield, James D., Price, Gavrielle M., Chickering, Jennifer G., Milne, G. Todd, Currie, Mark G., Masferrer, Jaime L.
Publicado 2020

Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo

por Ranganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G., Liu, Guang, Tran, Tran T., Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E., Graul, Chris, Griffin, Aliesha, Schairer, Wayne C., Higgins, Carolyn, Reza, Tammi L., Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim, Mandyam, Ramya A., Masferrer, Jaime, Liu, David, Patel, Dinesh V., Fretzen, Angelika, Murphy, Craig A., Milne, G. Todd, Smythe, Mark L., Carlson, Kenneth E.
Publicado 2015

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications: Bamberg, Germany. 23-25 June, 2017

por Todd Milne, G., Sandner, Peter, Lincoln, Kathleen A., Harrison, Paul C., Chen, Hongxing, Wang, Hong, Clifford, Holly, Qian, Hu Sheng, Wong, Diane, Sarko, Chris, Fryer, Ryan, Richman, Jeremy, Reinhart, Glenn A., Boustany, Carine M., Pullen, Steven S., Andresen, Henriette, Moltzau, Lise Román, Cataliotti, Alessandro, Levy, Finn Olav, Lukowski, Robert, Frankenreiter, Sandra, Friebe, Andreas, Calamaras, Timothy, Baumgartner, Robert, McLaughlin, Angela, Aronovitz, Mark, Baur, Wendy, Wang, Guang-Rong, Kapur, Navin, Karas, Richard, Blanton, Robert, Hell, Stefan, Waldman, Scott A., Lin, Jieru E., Colon-Gonzalez, Francheska, Kim, Gilbert W., Blomain, Erik S., Merlino, Dante, Snook, Adam, Erdmann, Jeanette, Wobst, Jana, Kessler, Thorsten, Schunkert, Heribert, Walter, Ulrich, Pagel, Oliver, Walter, Elena, Gambaryan, Stepan, Smolenski, Albert, Jurk, Kerstin, Zahedi, Rene, Klinger, James R., Benza, Raymond L., Corris, Paul A., Langleben, David, Naeije, Robert, Simonneau, Gérald, Meier, Christian, Colorado, Pablo, Chang, Mi Kyung, Busse, Dennis, Hoeper, Marius M., Masferrer, Jaime L., Jacobson, Sarah, Liu, Guang, Sarno, Renee, Bernier, Sylvie, Zhang, Ping, Todd Milne, G., Flores-Costa, Roger, Currie, Mark, Hall, Katherine, Möhrle, Dorit, Reimann, Katrin, Wolter, Steffen, Wolters, Markus, Mergia, Evanthia, Eichert, Nicole, Geisler, Hyun-Soon, Ruth, Peter, Friebe, Andreas, Feil, Robert, Zimmermann, Ulrike, Koesling, Doris, Knipper, Marlies, Rüttiger, Lukas, Tanaka, Yasutake, Okamoto, Atsuko, Nojiri, Takashi, Kumazoe, Motofumi, Tokudome, Takeshi, Miura, Koichi, Hino, Jun, Hosoda, Hiroshi, Miyazato, Mikiya, Kangawa, Kenji, Kapil, Vikas, Ahluwalia, Amrita, Paolocci, Nazareno, Eaton, Philip, Campbell, James C., Henning, Philipp, Franz, Eugen, Sankaran, Banumathi, Herberg, Friedrich W., Kim, Choel, Wittwer, M., Luo, Q., Kaila, V., Dames, S. A., Tobin, Andrew, Alam, Mahmood, Rudyk, Olena, Krasemann, Susanne, Hartmann, Kristin, Prysyazhna, Oleksandra, Zhang, Min, Zhao, Lan, Weiss, Astrid, Schermuly, Ralph, Eaton, Philip, Moyes, Amie J., Chu, Sandy M., Baliga, Reshma S., Hobbs, Adrian J., Michalakis, Stylianos, Mühlfriedel, Regine, Schön, Christian, Fischer, Dominik M., Wilhelm, Barbara, Zobor, Ditta, Kohl, Susanne, Peters, Tobias, Zrenner, Eberhart, Bartz-Schmidt, Karl Ulrich, Ueffing, Marius, Wissinger, Bernd, Seeliger, Mathias, Biel, Martin, Ranek, Mark J., Kokkonen, Kristen M., Lee, Dong I., Holewinski, Ronald J., Agrawal, Vineet, Virus, Cornelia, Stevens, Donté A., Sasaki, Masayuki, Zhang, Huaqun, Mannion, Mathew M., Rainer, Peter P., Page, Richard C., Schisler, Jonathan C., Van Eyk, Jennifer E., Willis, Monte S., Kass, David A., Zaccolo, Manuela, Russwurm, Michael, Giesen, Jan, Russwurm, Corina, Füchtbauer, Ernst-Martin, Koesling, Doris, Bork, Nadja I., Nikolaev, Viacheslav O., Agulló, Luis, Floor, Martin, Villà-Freixa, Jordi, Manfra, Ornella, Calamera, Gaia, Surdo, Nicoletta C., Meier, Silja, Froese, Alexander, Nikolaev, Viacheslav O., Zaccolo, Manuela, Levy, Finn Olav, Andressen, Kjetil Wessel, Aue, Annemarie, Schwiering, Fabian, Groneberg, Dieter, Friebe, Andreas, Bajraktari, Gzona, Burhenne, Jürgen, Haefeli, Walter E., Weiss, Johanna, Beck, Katharina, Voussen, Barbara, Vincent, Alexander, Parsons, Sean P., Huizinga, Jan D., Friebe, Andreas, Mónica, Fabiola Zakia, Seto, Edward, Murad, Ferid, Bian, Ka, Burgoyne, Joseph R., Prysyazhna, Oleksandra, Richards, Daniel, Eaton, Philip, Calamera, Gaia, Bjørnerem, Marianne, Ulsund, Andrea Hembre, Kim, Jeong Joo, Kim, Choel, Levy, Finn Olav, Andressen, Kjetil Wessel, Donzelli, Sonia, Goetz, Mara, Schmidt, Kjestine, Wolters, Markus, Stathopoulou, Konstantina, Prysyazhna, Oleksandra, Scotcher, Jenna, Dees, Christian, Subramanian, Hariharan, Butt, Elke, Kamynina, Alisa, Bruce King, S., Nikolaev, Viacheslav O., de Witt, Cor, Leichert, Lars I., Feil, Robert, Eaton, Philip, Cuello, Friederike, Dobrowinski, Hyazinth, Lehners, Moritz, Schmidt, Michael Paolillo Hannes, Feil, Robert, Feil, Susanne, Wen, Lai, Wolters, Markus, Thunemann, Martin, Schmidt, Kjestine, Olbrich, Marcus, Langer, Harald, Gawaz, Meinrad, Friebe, Andreas, de Wit, Cor, Feil, Robert, Franz, Eugen, Kim, Jeong Joo, Bertinetti, Daniela, Kim, Choel, Herberg, Friedrich W., Ghofrani, Hossein-Ardeschir, Grimminger, Friedrich, Grünig, Ekkehard, Huang, Yigao, Jansa, Pavel, Jing, Zhi Cheng, Kilpatrick, David, Langleben, David, Rosenkranz, Stephan, Menezes, Flavia, Fritsch, Arno, Nikkho, Sylvia, Frey, Reiner, Humbert, Marc, Groneberg, Dieter, Aue, Annemarie, Schwiering, Fabian, Friebe, Andreas, Harloff, Manuela, Reinders, Joerg, Schlossmann, Jens, Jung, Joon, Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Solinga, Robert, Sheppeck, James E., Renhowe, Paul A., Montfort, William R., Qin, Liying, Sung, Ying-Ju, Casteel, Darren, Kim, Choel, Kollau, Alexander, Neubauer, Andrea, Schrammel, Astrid, Russwurm, Michael, Koesling, Doris, Mayer, Bernd, Kumazoe, Motofumi, Takai, Mika, Takeuchi, Chieri, Kadomatsu, Mai, Hiroi, Shun, Takamatsu, Kanako, Nojiri, Takashi, Kangawa, Kenji, Tachibana, Hirofumi, Opelt, Marissa, Eroglu, Emrah, Waldeck-Weiermair, Markus, Russwurm, Michael, Koesling, Doris, Malli, Roland, Graier, Wolfgang F., Fassett, John T., Schrammel, Astrid, Mayer, Bernd, Sollie, Selene J., Moltzau, Lise Román, Hernandez-Valladares, Maria, Berven, Frode, Levy, Finn Olav, Andressen, Kjetil W., Nojiri, Takashi, Tokudome, Takeshi, Kumazoe, Motofumi, Arai, Miki, Suzuki, Yutaka, Miura, Koichi, Hino, Jun, Hosoda, Hiroshi, Miyazato, Mikiya, Okumura, Meinoshin, Kawaoka, Shinpei, Kangawa, Kenji, Peters, Stefanie, Schmidt, Hannes, Selin Kenet, B., Nies, Sarah Helena, Frank, Katharina, Wen, Lai, Rathjen, Fritz G., Feil, Robert, Petrova, Olga N., Lamarre, Isabelle, Négrerie, Michel, Robinson, Jerid W., Egbert, Jeremy R., Davydova, Julia, Jaffe, Laurinda A., Potter, Lincoln R., Robinson, Jerid W., Blixt, Nicholas, Shuhaibar, Leia C., Warren, Gordon L., Mansky, Kim C., Jaffe, Laurinda A., Potter, Lincoln R., Romoli, Simone, Bauch, Tobias, Dröbner, Karoline, Eitner, Frank, Ruppert, Mihály, Radovits, Tamás, Korkmaz-Icöz, Sevil, Li, Shiliang, Hegedűs, Péter, Loganathan, Sivakanan, Németh, Balázs Tamás, Oláh, Attila, Mátyás, Csaba, Benke, Kálmán, Merkely, Béla, Karck, Matthias, Szabó, Gábor, Scheib, Ulrike, Broser, Matthias, Mukherjee, Shatanik, Stehfest, Katja, Gee, Christine E., Körschen, Heinz G., Oertner, Thomas G., Hegemann, Peter, Schmidt, Hannes, Dickey, Deborah M., Dumoulin, Alexandre, Kühn, Ralf, Jaffe, Laurinda, Potter, Lincoln R., Rathjen, Fritz G., Schobesberger, Sophie, Wright, Peter, Poulet, Claire, Mansfield, Catherine, Friebe, Andreas, Harding, Sian E., Nikolaev, Viacheslav O., Gorelik, Julia, Kollau, Alexander, Opelt, Marissa, Wölkart, Gerald, Gorren, Antonius C. F., Russwurm, Michael, Koesling, Doris, Schrammel, Astrid, Mayer, Bernd, Schwaerzer, Gerburg K., Casteel, Darren E., Dalton, Nancy D., Gu, Yusu, Zhuang, Shunhui, Milewicz, Dianna M., Peterson, Kirk L., Pilz, Renate, Schwiering, Fabian, Aue, Annemarie, Groneberg, Dieter, Friebe, Andreas, Argyriou, Aikaterini I., Makrynitsa, Garyfalia, Alexandropoulos, Ioannis I., Stamopoulou, Andriana, Bantzi, Marina, Giannis, Athanassios, Topouzis, Stavros, Papapetropoulos, Andreas, Spyroulias, Georgios A., Stuehr, Dennis J., Ghosh, Arnab, Dai, Yue, Misra, Saurav, Tchernychev, Boris, Jung, Joon, Liu, Guang, Silos-Santiago, Inmaculada, Hannig, Gerhard, Dao, Vu Thao-Vi, Deile, Martin, Nedvetsky, Pavel I., Güldner, Andreas, Ibarra-Alvarado, César, Gödecke, Axel, Schmidt, Harald H. H. W., Vachaviolos, Angelos, Gerling, Andrea, Thunemann, Martin, Lutz, Stefan Z., Häring, Hans-Ulrich, Krüger, Marcel A., Pichler, Bernd J., Shipston, Michael J., Feil, Susanne, Feil, Robert, Vandenwijngaert, Sara, Ledsky, Clara D., Agha, Obiajulu, Hu, Dongjian, Domian, Ibrahim J., Buys, Emmanuel S., Newton-Cheh, Christopher, Bloch, Donald B., Voussen, Barbara, Beck, Katharina, Mauro, Nadine, Keppler, Jonas, Friebe, Andreas, Ferreira, Wilson A., Chweih, Hanan, Brito, Pamela L., Almeida, Camila B., Penteado, Carla F. F., Saad, Sara S. O., Costa, Fernando F., Frenette, Paul S., Brockschnieder, Damian, Stasch, Johannes-Peter, Sandner, Peter, Conran, Nicola, Zimmer, Daniel P., Tobin, Jenny, Shea, Courtney, Sarno, Renee, Long, Kimberly, Jacobson, Sarah, Tang, Kim, Germano, Peter, Wakefield, James, Banijamali, Ali, Im, G-Yoon Jamie, Sheppeck, James E., Profy, Albert T., Todd Milne, G., Currie, Mark G., Masferrer, Jaime L.
Publicado 2017