TGF-β in developmental and fibrogenic EMTs

por Lee, Jun Ho, Massagué, Joan
Publicado 2022

Understanding the molecular mechanisms driving metastasis

por Massagué, Joan, Batlle, Eduard, Gomis, Roger R.
Publicado 2017

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

por Morgani, Sophie M, Su, Jie, Nichols, Jennifer, Massagué, Joan, Hadjantonakis, Anna-Katerina
Publicado 2021

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

por Vanharanta, Sakari, Marney, Christina B, Shu, Weiping, Valiente, Manuel, Zou, Yilong, Mele, Aldo, Darnell, Robert B, Massagué, Joan
Publicado 2014

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

por Basnet, Harihar, Tian, Lin, Ganesh, Karuna, Huang, Yun-Han, Macalinao, Danilo G, Brogi, Edi, Finley, Lydia WS, Massagué, Joan
Publicado 2019

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

por Schultz, Nikolaus, Marenstein, Dina R, De Angelis, Dino A, Wang, Wei-Qing, Nelander, Sven, Jacobsen, Anders, Marks, Debora S, Massagué, Joan, Sander, Chris
Publicado 2011

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

por Foletta, Victoria C., Lim, Mei Ann, Soosairajah, Juliana, Kelly, April P., Stanley, Edouard G., Shannon, Mark, He, Wei, Das, Supratik, Massagué, Joan, Bernard, Ora
Publicado 2003

Epigenetic expansion of VHL-HIF signal output drives multi-organ metastasis in renal cancer

por Vanharanta, Sakari, Shu, Weiping, Brenet, Fabienne, Hakimi, A. Ari, Heguy, Adriana, Viale, Agnes, Reuter, Victor E., Hsieh, James J.-D., Scandura, Joseph M., Massagué, Joan
Publicado 2012

Therapy-induced tumour secretomes promote resistance and tumour progression

por Obenauf, Anna C., Zou, Yilong, Ji, Andrew L., Vanharanta, Sakari, Shu, Weiping, Shi, Hubing, Kong, Xiangju, Bosenberg, Marcus C., Wiesner, Thomas, Rosen, Neal, Lo, Roger S., Massagué, Joan
Publicado 2015

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

por Chen, Qing, Boire, Adrienne, Jin, Xin, Valiente, Manuel, Er, Ekrem Emrah, Lopez-Soto, Alejandro, Jacob, Leni, Patwa, Ruzeen, Shah, Hardik, Xu, Ke, Cross, Justin R., Massagué, Joan
Publicado 2016

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1

por Pluta, Radoslaw, Aragón, Eric, Prescott, Nicholas A., Ruiz, Lidia, Mees, Rebeca A., Baginski, Blazej, Flood, Julia R., Martin-Malpartida, Pau, Massagué, Joan, David, Yael, Macias, Maria J.
Publicado 2022

RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation

por Morales, Mònica, Arenas, Enrique J, Urosevic, Jelena, Guiu, Marc, Fernández, Esther, Planet, Evarist, Fenwick, Robert Bryn, Fernández-Ruiz, Sonia, Salvatella, Xavier, Reverter, David, Carracedo, Arkaitz, Massagué, Joan, Gomis, Roger R
Publicado 2014

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

por Martin-Malpartida, Pau, Batet, Marta, Kaczmarska, Zuzanna, Freier, Regina, Gomes, Tiago, Aragón, Eric, Zou, Yilong, Wang, Qiong, Xi, Qiaoran, Ruiz, Lidia, Vea, Angela, Márquez, José A., Massagué, Joan, Macias, Maria J.
Publicado 2017

Analysis of tumor- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S

por Sevenich, Lisa, Bowman, Robert L., Mason, Steven D., Quail, Daniela F., Rapaport, Franck, Elie, Benelita T., Brogi, Edi, Brastianos, Priscilla K., Hahn, William C., Holsinger, Leslie J., Massagué, Joan, Leslie, Christina S., Joyce, Johanna A.
Publicado 2014

H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling

por Luo, Maoguo, Bai, Jianbo, Liu, Bofeng, Yan, Peiqiang, Zuo, Feifei, Sun, Hongyao, Sun, Ye, Xu, Xuanhao, Song, Zhihong, Yang, Yang, Massagué, Joan, Lan, Xun, Lu, Zhi, Chen, Ye-Guang, Deng, Haiteng, Xie, Wei, Xi, Qiaoran
Publicado 2019

Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas

por Paik, Paul K., Luo, Jia, Ai, Ni, Kim, Rachel, Ahn, Linda, Biswas, Anup, Coker, Courtney, Ma, Wanchao, Wong, Phillip, Buonocore, Darren J., Lai, W. Victoria, Chaft, Jamie E., Acharyya, Swarnali, Massagué, Joan, Kris, Mark G.
Publicado 2022

Distinct tumor architectures for metastatic colonization of the brain

por Gan, Siting, Macalinao, Danilo G., Shahoei, Sayyed Hamed, Tian, Lin, Jin, Xin, Basnet, Harihar, Muller, James T., Atri, Pranita, Seffar, Evan, Chatila, Walid, Hadjantonakis, Anna-Katerina, Schultz, Nikolaus, Brogi, Edi, Bale, Tejus A., Pe’er, Dana, Massagué, Joan
Publicado 2023

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

por Aragón, Eric, Wang, Qiong, Zou, Yilong, Morgani, Sophie M., Ruiz, Lidia, Kaczmarska, Zuzanna, Su, Jie, Torner, Carles, Tian, Lin, Hu, Jing, Shu, Weiping, Agrawal, Saloni, Gomes, Tiago, Márquez, José A., Hadjantonakis, Anna-Katerina, Macias, Maria J., Massagué, Joan
Publicado 2019

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

por Laughney, Ashley M., Hu, Jing, Campbell, Nathaniel R., Bakhoum, Samuel F., Setty, Manu, Lavallée, Vincent-Philippe, Xie, Yubin, Masilionis, Ignas, Carr, Ambrose J., Kottapalli, Sanjay, Allaj, Viola, Mattar, Marissa, Rekhtman, Natasha, Xavier, Joao B., Mazutis, Linas, Poirier, John T., Rudin, Charles M., Pe’er, Dana, Massagué, Joan
Publicado 2020

Genome-scale screens identify JNK/JUN signaling as a barrier for pluripotency exit and endoderm differentiation

por Li, Qing V., Dixon, Gary, Verma, Nipun, Rosen, Bess P., Gordillo, Miriam, Luo, Renhe, Xu, Chunlong, Wang, Qiong, Soh, Chew-Li, Yang, Dapeng, Crespo, Miguel, Shukla, Abhijit, Xiang, Qing, Dündar, Friederike, Zumbo, Paul, Witkin, Matthew, Koche, Richard, Betel, Doron, Chen, Shuibing, Massagué, Joan, Garippa, Ralph, Evans, Todd, Beer, Michael A., Huangfu, Danwei
Publicado 2019