Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach

por Uytterhoeven, Birgit, Appermans, Kenny, Song, Lijiang, Masschelein, Joleen, Lathouwers, Thomas, Michiels, Chris W., Lavigne, Rob
Publicado 2015

Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism

por Nakou, Ioanna T., Jenner, Matthew, Dashti, Yousef, Romero‐Canelón, Isolda, Masschelein, Joleen, Mahenthiralingam, Eshwar, Challis, Gregory L.
Publicado 2020

Genome Sequence of Serratia plymuthica RVH1, Isolated from a Raw Vegetable-Processing Line

por Van Houdt, Rob, Van der Lelie, Daniel, Izquierdo, Javier A., Aertsen, Abram, Masschelein, Joleen, Lavigne, Rob, Michiels, Chris W., Taghavi, Safiyh
Publicado 2014

A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics

por Masschelein, Joleen, Clauwers, Charlien, Awodi, Ufedo R., Stalmans, Karen, Vermaelen, Wesley, Lescrinier, Eveline, Aertsen, Abram, Michiels, Chris, Challis, Gregory L., Lavigne, Rob
Publicado 2015

S3.4c A pipeline toward the identification of novel antifungal compounds derived from the microbial dark matter

por Vanreppelen, Giel, Wuyts, Jurgen, Holderbusch, Alannah, Peys, Alexander, Hu, Haibo, De Ruysscher, Dries, Masschelein, Joleen, Luyten, Walter, Vandecruys, Paul, Van Dijck, Patrick
Publicado 2022

A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis

por Masschelein, Joleen, Sydor, Paulina K., Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M., Ling Yap, Zhong, Parkhill, Julian, Mahenthiralingam, Eshwar, Challis, Gregory L.
Publicado 2019

A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics

por Masschelein, Joleen, Mattheus, Wesley, Gao, Ling-Jie, Moons, Pieter, Van Houdt, Rob, Uytterhoeven, Birgit, Lamberigts, Chris, Lescrinier, Eveline, Rozenski, Jef, Herdewijn, Piet, Aertsen, Abram, Michiels, Chris, Lavigne, Rob
Publicado 2013

An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics

por Jenner, Matthew, Jian, Xinyun, Dashti, Yousef, Masschelein, Joleen, Hobson, Christian, Roberts, Douglas M., Jones, Cerith, Harris, Simon, Parkhill, Julian, Raja, Huzefa A., Oberlies, Nicholas H., Pearce, Cedric J., Mahenthiralingam, Eshwar, Challis, Gregory L.
Publicado 2019

Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics

por Thistlethwaite, Iain R. G., Bull, Freya M., Cui, Chengsen, Walker, Paul D., Gao, Shu-Shan, Wang, Luoyi, Song, Zhongshu, Masschelein, Joleen, Lavigne, Rob, Crump, Matthew P., Race, Paul R., Simpson, Thomas J., Willis, Christine L.
Publicado 2017

Structural basis for chain release from the enacyloxin polyketide synthase

por Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L.C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L., Lewandowski, Józef R.
Publicado 2019

A conserved motif flags Acyl Carrier Proteins for β-branching in polyketide synthesis

por Haines, Anthony S, Dong, Xu, Song, Zhongshu, Farmer, Rohit, Williams, Christopher, Hothersall, Joanne, Płoskoń, Eliza, Wattana-amorn, Pakorn, Stephens, Elton R., Yamada, Erika, Gurney, Rachel, Takebayashi, Yuiko, Masschelein, Joleen, Cox, Russell J., Lavigne, Rob, Willis, Christine L., Simpson, Thomas J., Crosby, John, Winn, Peter J., Thomas, Christopher M., Crump, Matthew P.
Publicado 2013