Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC

por Massey, Andrew J.
Publicado 2015

Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity

por Massey, Andrew J.
Publicado 2016

Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage

por Massey, Andrew J.
Publicado 2017

A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells

por Massey, Andrew J.
Publicado 2018

γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments

por Rawlinson, Rebecca, Massey, Andrew J
Publicado 2014

Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells

por Bryant, Christopher, Scriven, Kirsten, Massey, Andrew J
Publicado 2014

Chk1 Inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers

por Bryant, Christopher, Rawlinson, Rebecca, Massey, Andrew J
Publicado 2014

Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase

por Wayne, Joanne, Brooks, Teresa, Massey, Andrew J.
Publicado 2016

Checkpoint Kinase 1 (Chk1) inhibition fails to activate the Stimulator of Interferon Genes (STING) innate immune signalling in a human coculture cancer system

por Brooks, Teresa, Wayne, Joanne, Massey, Andrew J.
Publicado 2021

Targeting DYRK1A/B kinases to modulate p21‐cyclin D1‐p27 signalling and induce anti‐tumour activity in a model of human glioblastoma

por Massey, Andrew J., Benwell, Karen, Burbridge, Mike, Kotschy, Andras, Walmsley, David Lee
Publicado 2021

Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor

por Massey, Andrew J., Borgognoni, Jenifer, Bentley, Carol, Foloppe, Nicolas, Fiumana, Andrea, Walmsley, Lee
Publicado 2010

Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design

por Massey, Andrew J., Stokes, Stephen, Browne, Helen, Foloppe, Nicolas, Fiumana, Andreá, Scrace, Simon, Fallowfield, Mandy, Bedford, Simon, Webb, Paul, Baker, Lisa, Christie, Mark, Drysdale, Martin J., Wood, Mike
Publicado 2015

The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells

por Johansen, Valdemar B. I., Hampson, Elizabeth, Tsonou, Elpida, Pantarelli, Chiara, Chu, Julia Y., Crossland, Laraine, Okkenhaug, Hanneke, Massey, Andrew J., Hornigold, David C., Welch, Heidi C. E., Chetwynd, Stephen A.
Publicado 2023