Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency

por Hou, Zhanjun, Orr, Steve, Matherly, Larry H.
Publicado 2014

The evolving biology of the proton‐coupled folate transporter: New insights into regulation, structure, and mechanism

por Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Publicado 2022

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer

por Desmoulin, Sita Kugel, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Publicado 2012

Substrate-specific binding and conformational changes involving Ser(313) and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis...

por Hou, Zhanjun, Wu, Jianmei, Ye, Jun, Cherian, Christina, Matherly, Larry H.
Publicado 2010

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer

por Wallace-Povirk, Adrianne, Hou, Zhanjun, Nayeen, Md. Junayed, Gangjee, Aleem, Matherly, Larry H.
Publicado 2021

Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data

por Burton, Jordan B., Carruthers, Nicholas J., Hou, Zhanjun, Matherly, Larry H., Stemmer, Paul M.
Publicado 2022

Overexpression of GATA1 Confers Resistance to Chemotherapy in Acute Megakaryocytic Leukemia

por Caldwell, John Timothy, Edwards, Holly, Dombkowski, Alan A., Buck, Steven A., Matherly, Larry H., Ge, Yubin, Taub, Jeffrey W.
Publicado 2013

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

por Frigerio, Barbara, Bizzoni, Claudia, Jansen, Gerrit, Leamon, Christopher P., Peters, Godefridus J., Low, Philip S., Matherly, Larry H., Figini, Mariangela
Publicado 2019

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

por O’Connor, Carrie, Wallace-Povirk, Adrianne, Ning, Changwen, Frühauf, Josephine, Tong, Nian, Gangjee, Aleem, Matherly, Larry H., Hou, Zhanjun
Publicado 2021

Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance

por Farran, Batoul, Albayrak, Samet, Abrams, Judith, Tainsky, Michael A., Levin, Nancy K., Morris, Robert, Matherly, Larry H., Ratnam, Manohar, Winer, Ira
Publicado 2019

Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the P...

por Golani, Lalit K., George, Christina, Zhao, Sai, Raghavan, Sudhir, Orr, Steven, Wallace, Adrianne, Wilson, Mike R., Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Publicado 2014

Correction to Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α a...

por Golani, Lalit K., George, Christina, Zhao, Sai, Raghavan, Sudhir, Orr, Steven, Wallace, Adrianne, Wilson, Mike R., Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Publicado 2016

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the...

por Sarkisjan, Dzjemma, Julsing, Joris R., El Hassouni, Btissame, Honeywell, Richard J., Kathmann, Ietje, Matherly, Larry H., Lee, Young B., Kim, Deog J., Peters, Godefridus J.
Publicado 2020

Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia

por Edwards, Holly, Rubenstein, Mara, Dombkowski, Alan A., Caldwell, J. Timothy, Chu, Roland, Xavier, Ana C., Thummel, Ryan, Neely, Melody, Matherly, Larry H., Ge, Yubin, Taub, Jeffrey W.
Publicado 2016

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group

por Gedman, Amanda Larson, Chen, Qing, Desmoulin, Sita Kugel, Ge, Yubin, LaFiura, Katherine, Haska, Christina L., Cherian, Christina, Devidas, Meenakshi, Linda, Stephen B., Taub, Jeffrey W., Matherly, Larry H.
Publicado 2009

A Unique Role of GATA1s in Down Syndrome Acute Megakaryocytic Leukemia Biology and Therapy

por Xavier, Ana C., Edwards, Holly, Dombkowski, Alan A., Balci, Tugce B., Berman, Jason N., Dellaire, Graham, Xie, Chengzhi, Buck, Steven A., Matherly, Larry H., Ge, Yubin, Taub, Jeffrey W.
Publicado 2011

Chronic p27(Kip1) Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor

por Patki, Mugdha, McFall, Thomas, Rosati, Rayna, Huang, Yanfang, Malysa, Agnes, Polin, Lisa, Fielder, Abigail, Wilson, Mike R., Lonardo, Fulvio, Back, Jessica, Li, Jing, Matherly, Larry H., Bepler, Gerold, Ratnam, Manohar
Publicado 2018

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

por Shields, Jeremiah N., Hales, Eric C., Ranspach, Lillian E., Luo, Xixia, Orr, Steven, Runft, Donna, Dombkowski, Alan, Neely, Melody N., Matherly, Larry H., Taub, Jeffrey W., Baker, Tracie R., Thummel, Ryan
Publicado 2019

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

por Nayeen, Md. Junayed, Katinas, Jade M., Magdum, Tejashree, Shah, Khushbu, Wong, Jennifer E., O’Connor, Carrie E., Fifer, Alexandra N., Wallace-Povirk, Adrianne, Hou, Zhanjun, Matherly, Larry H., Dann, Charles E., Gangjee, Aleem
Publicado 2023

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

por Wallace-Povirk, Adrianne, Rubinsak, Lisa, Malysa, Agnes, Dzinic, Sijana H., Ravindra, Manasa, Schneider, Mathew, Glassbrook, James, O’Connor, Carrie, Hou, Zhanjun, Kim, Seongho, Back, Jessica, Polin, Lisa, Morris, Robert T., Gangjee, Aleem, Gibson, Heather, Matherly, Larry H.
Publicado 2022