Enhanced interpretation of 935 hotspot and non-hotspot RAS variants using evidence-based structural bioinformatics

por Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Leverence, Elise, Urrutia, Raul, Zimmermann, Michael T.
Publicado 2021

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function

por Stancill, Jennifer S, Hansen, Polly A, Mathison, Angela J, Schmidt, Edward E, Corbett, John A
Publicado 2022

Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression

por Grzenda, Adrienne, Leonard, Phoebe, Seo, Seungmae, Mathison, Angela J, Urrutia, Guillermo, Calvo, Ezequiel, Iovanna, Juan, Urrutia, Raul, Lomberk, Gwen
Publicado 2013

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons

por Allison, Reilly L., Adelman, Jacob W., Abrudan, Jenica, Urrutia, Raul A., Zimmermann, Michael T., Mathison, Angela J., Ebert, Allison D.
Publicado 2022

A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1

por Chi, Young-In, Jorge, Salomão D., Jensen, Davin R., Smith, Brian C., Volkman, Brian F., Mathison, Angela J., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul
Publicado 2023

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability

por Williams, Monique M., Mathison, Angela J., Christensen, Trent, Greipp, Patricia T., Knutson, Darlene L., Klee, Eric W., Zimmermann, Michael T., Iovanna, Juan, Lomberk, Gwen A., Urrutia, Raul A.
Publicado 2019

A Novel Role of the Sp/KLF Transcription Factor KLF11 in Arresting Progression of Endometriosis

por Daftary, Gaurang S., Zheng, Ye, Tabbaa, Zaid M., Schoolmeester, John K., Gada, Ravi P., Grzenda, Adrienne L., Mathison, Angela J., Keeney, Gary L., Lomberk, Gwen A., Urrutia, Raul
Publicado 2013

Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level

por Zimmermann, Michael T., Mathison, Angela J., Stodola, Tim, Evans, Douglas B., Abrudan, Jenica L., Demos, Wendy, Tschannen, Michael, Aldakkak, Mohammed, Geurts, Jennifer, Lomberk, Gwen, Tsai, Susan, Urrutia, Raul
Publicado 2021

Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers

por Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Leverence, Elise N., Smith, Brian C., Volkman, Brian F., Mathison, Angela J., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul
Publicado 2022

Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys–Dietz syndrome (LDS) impairs canonical TGF-β signaling

por Cousin, Margot A., Zimmermann, Michael T., Mathison, Angela J., Blackburn, Patrick R., Boczek, Nicole J., Oliver, Gavin R., Lomberk, Gwen A., Urrutia, Raul A., Deyle, David R., Klee, Eric W.
Publicado 2017

Sequence-specific Recruitment of Heterochromatin Protein 1 via Interaction with Krüppel-like Factor 11, a Human Transcription Factor Involved in Tumor Suppression and Metabolic Dis...

por Lomberk, Gwen, Mathison, Angela J., Grzenda, Adrienne, Seo, Seungmae, DeMars, Cathrine J., Rizvi, Sumera, Bonilla-Velez, Juliana, Calvo, Ezequiel, Fernandez-Zapico, Martin E., Iovanna, Juan, Buttar, Navtej S., Urrutia, Raul
Publicado 2012

Kras(G12D) induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells

por Mathison, Angela J., Kerketta, Romica, de Assuncao, Thiago Milech, Leverence, Elise, Zeighami, Atefeh, Urrutia, Guillermo, Stodola, Timothy J., di Magliano, Marina Pasca, Iovanna, Juan L., Zimmermann, Michael T., Lomberk, Gwen, Urrutia, Raul
Publicado 2021

Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1‐like (DOT1L) and partnering complexes involved in leukemogenesis...

por Stodola, Timothy J., Chi, Young‐In, De Assuncao, Thiago M., Leverence, Elise N., Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Volkman, Brian F., Smith, Brian C., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul
Publicado 2021

A timeline of genetic variant enrichment: from multiple myeloma diagnosis to myeloma-associated myeloid malignancy

por Kleman, Ariel, Singavi, Arun, Pommert, Lauren, Mathison, Angela J., Hari, Parameswaran, Dhakal, Binod, Mohan, Meera, Janz, Siegfried, Knight, Jennifer M., Shah, Mithun V., Schinke, Carolina, Burns, Robert, Steinhardt, George Francis, Rao, Sridhar, Carlson, Karen
Publicado 2023

Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by A...

por Urrutia, Guillermo, de Assuncao, Thiago Milech, Mathison, Angela J., Salmonson, Ann, Kerketta, Romica, Zeighami, Atefeh, Stodola, Timothy J., Adsay, Volkan, Pehlivanoglu, Burcin, Dwinell, Michael B., Zimmermann, Michael T., Iovanna, Juan L., Urrutia, Raul, Lomberk, Gwen
Publicado 2021

Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and En...

por Daftary, Gaurang S., Lomberk, Gwen A., Buttar, Navtej S., Allen, Thomas W., Grzenda, Adrienne, Zhang, Jinsan, Zheng, Ye, Mathison, Angela J., Gada, Ravi P., Calvo, Ezequiel, Iovanna, Juan L., Billadeau, Daniel D., Prendergast, Franklyn G., Urrutia, Raul
Publicado 2012

Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction

por Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Levrence, Elise N., Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Basel, Donald G., Volkman, Brian F., Smith, Brian C., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul
Publicado 2021

Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction

por Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Levrence, Elise N., Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Basel, Donald G., Volkman, Brian F., Smith, Brian C., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul
Publicado 2021

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape

por Ratnasinghe, Brian D., Haque, Neshatul, Wagenknecht, Jessica B., Jensen, Davin R., Esparza, Guadalupe V., Leverence, Elise N., De Assuncao, Thiago Milech, Mathison, Angela J., Lomberk, Gwen, Smith, Brian C., Volkman, Brian F., Urrutia, Raul, Zimmermann, Michael T.
Publicado 2023

Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape

por Ratnasinghe, Brian D., Haque, Neshatul, Wagenknecht, Jessica B., Jensen, Davin R., Valdivia Esparza, Guadalupe K., Leverence, Elise N., Milech De Assuncao, Thiago, Mathison, Angela J., Lomberk, Gwen, Smith, Brian C., Volkman, Brian F., Urrutia, Raul, Zimmermann, Michael T.
Publicado 2023