Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications

por Okubo, Hirofumi, Kushiyama, Akifumi, Nakatsu, Yusuke, Yamamotoya, Takeshi, Matsunaga, Yasuka, Fujishiro, Midori, Sakoda, Hideyuki, Ohno, Haruya, Yoneda, Masayasu, Asano, Tomoichiro
Publicado 2018

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus

por Qiang, Shirong, Nakatsu, Yusuke, Seno, Yasuyuki, Fujishiro, Midori, Sakoda, Hideyuki, Kushiyama, Akifumi, Mori, Keiichi, Matsunaga, Yasuka, Yamamotoya, Takeshi, Kamata, Hideaki, Asano, Tomoichiro
Publicado 2015

Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations

por Nakatsu, Yusuke, Matsunaga, Yasuka, Yamamotoya, Takeshi, Ueda, Koji, Inoue, Yuki, Mori, Keiichi, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kushiyama, Akifumi, Asano, Tomoichiro
Publicado 2016

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis

por Kushiyama, Akifumi, Nakatsu, Yusuke, Matsunaga, Yasuka, Yamamotoya, Takeshi, Mori, Keiichi, Ueda, Koji, Inoue, Yuki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Asano, Tomoichiro
Publicado 2016

Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells

por Hasei, Shun, Yamamotoya, Takeshi, Nakatsu, Yusuke, Ohata, Yukino, Itoga, Shota, Nonaka, Yuji, Matsunaga, Yasuka, Sakoda, Hideyuki, Fujishiro, Midori, Kushiyama, Akifumi, Asano, Tomoichiro
Publicado 2021

Nicotinamide N-methyltransferase mediates lipofibroblast–myofibroblast transition and apoptosis resistance

por Rehan, Mohammad, Deskin, Brian, Kurundkar, Ashish R., Yadav, Santosh, Matsunaga, Yasuka, Manges, Justin, Smith, Nia, Dsouza, Kevin G., Burow, Matthew E., Thannickal, Victor J.
Publicado 2023

Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice

por Yamamotoya, Takeshi, Nakatsu, Yusuke, Matsunaga, Yasuka, Fukushima, Toshiaki, Yamazaki, Hiroki, Kaneko, Sunao, Fujishiro, Midori, Kikuchi, Takako, Kushiyama, Akifumi, Tokunaga, Fuminori, Asano, Tomoichiro, Sakoda, Hideyuki
Publicado 2017

Pathological Role of Pin1 in the Development of DSS-Induced Colitis

por Matsunaga, Yasuka, Hasei, Shun, Yamamotoya, Takeshi, Honda, Hiroaki, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Ito, Hisanaka, Okabe, Takayoshi, Asano, Tomoichiro, Nakatsu, Yusuke
Publicado 2021

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

por Inoue, Masa-Ki, Nakatsu, Yusuke, Yamamotoya, Takeshi, Hasei, Shun, Kanamoto, Mayu, Naitou, Miki, Matsunaga, Yasuka, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kushiyama, Akifumi, Asano, Tomoichiro
Publicado 2019

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines

por Kanaoka, Ryuhei, Kushiyama, Akifumi, Seno, Yasuyuki, Nakatsu, Yusuke, Matsunaga, Yasuka, Fukushima, Toshiaki, Tsuchiya, Yoshihiro, Sakoda, Hideyuki, Fujishiro, Midori, Yamamotoya, Takeshi, Kamata, Hideaki, Matsubara, Akio, Asano, Tomoichiro
Publicado 2015

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity

por Yamamotoya, Takeshi, Nakatsu, Yusuke, Kushiyama, Akifumi, Matsunaga, Yasuka, Ueda, Koji, Inoue, Yuki, Inoue, Masa-Ki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kiyonari, Hiroshi, Ishihara, Hisamitsu, Asano, Tomoichiro
Publicado 2017

The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic A...

por Nakatsu, Yusuke, Kokubo, Hiroki, Bumdelger, Batmunkh, Yoshizumi, Masao, Yamamotoya, Takeshi, Matsunaga, Yasuka, Ueda, Koji, Inoue, Yuki, Inoue, Masa-Ki, Fujishiro, Midori, Kushiyama, Akifumi, Ono, Hiraku, Sakoda, Hideyuki, Asano, Tomoichiro
Publicado 2017

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation

por Ueda, Koji, Nakatsu, Yusuke, Yamamotoya, Takeshi, Ono, Hiraku, Inoue, Yuki, Inoue, Masa-Ki, Mizuno, Yu, Matsunaga, Yasuka, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Takahashi, Shin-Ichiro, Matsubara, Akio, Asano, Tomoichiro
Publicado 2019

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

por Matsunaga, Yasuka, Nakatsu, Yusuke, Fukushima, Toshiaki, Okubo, Hirofumi, Iwashita, Misaki, Sakoda, Hideyuki, Fujishiro, Midori, Yamamotoya, Takeshi, Kushiyama, Akifumi, Takahashi, Shin-ichiro, Tsuchiya, Yoshihiro, Kamata, Hideaki, Tokunaga, Fuminori, Iwai, Kazuhiro, Asano, Tomoichiro
Publicado 2015

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model

por Inoue, Masa-Ki, Yamamotoya, Takeshi, Nakatsu, Yusuke, Ueda, Koji, Inoue, Yuki, Matsunaga, Yasuka, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Suzuki, Yusuke, Asano, Tomoichiro, Kushiyama, Akifumi
Publicado 2018

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice

por Inoue, Masa-Ki, Matsunaga, Yasuka, Nakatsu, Yusuke, Yamamotoya, Takeshi, Ueda, Koji, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Iwashita, Misaki, Sano, Tomomi, Nishimura, Fusanori, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Asano, Tomoichiro
Publicado 2019

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice

por Mizuno, Yu, Yamamotoya, Takeshi, Nakatsu, Yusuke, Ueda, Koji, Matsunaga, Yasuka, Inoue, Masa-Ki, Sakoda, Hideyuki, Fujishiro, Midori, Ono, Hiraku, Kikuchi, Takako, Takahashi, Masahiro, Morii, Kenichi, Sasaki, Kensuke, Masaki, Takao, Asano, Tomoichiro, Kushiyama, Akifumi
Publicado 2019