Pathogenic gain-of-function mutations in the prodomain and C-terminal domain of PCSK9 inhibit LDL binding

por Sarkar, Samantha K., Matyas, Angela, Asikhia, Ikhuosho, Hu, Zhenkun, Golder, Mia, Beehler, Kaitlyn, Kosenko, Tanja, Lagace, Thomas A.
Publicado 2022

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

por Sarkar, Samantha K., Foo, Alexander C. Y., Matyas, Angela, Asikhia, Ikhuosho, Kosenko, Tanja, Goto, Natalie K., Vergara-Jaque, Ariela, Lagace, Thomas A.
Publicado 2020