Molecular regulation and pharmacological targeting of the β‐catenin destruction complex

por van Kappel, Eline C, Maurice, Madelon M
Publicado 2017

Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer

por Spit, Maureen, Koo, Bon-Kyoung, Maurice, Madelon M.
Publicado 2018

Organoid-based modeling of intestinal development, regeneration, and repair

por Sprangers, Joep, Zaalberg, Irene C., Maurice, Madelon M.
Publicado 2020

Determining Biophysical Protein Stability in Lysates by a Fast Proteolysis Assay, FASTpp

por Minde, David P., Maurice, Madelon M., Rüdiger, Stefan G. D.
Publicado 2012

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

por Minde, David P, Anvarian, Zeinab, Rüdiger, Stefan GD, Maurice, Madelon M
Publicado 2011

Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes

por Gerlach, Jan P., Emmink, Benjamin L., Nojima, Hisashi, Kranenburg, Onno, Maurice, Madelon M.
Publicado 2014

Large Extent of Disorder in Adenomatous Polyposis Coli Offers a Strategy to Guard Wnt Signalling against Point Mutations

por Minde, David P., Radli, Martina, Forneris, Federico, Maurice, Madelon M., Rüdiger, Stefan G. D.
Publicado 2013

Three-dimensional analysis of single molecule FISH in human colon organoids

por Omerzu, Manja, Fenderico, Nicola, de Barbanson, Buys, Sprangers, Joep, de Ridder, Jeroen, Maurice, Madelon M.
Publicado 2019

Wnt Signaling Directs Neuronal Polarity and Axonal Growth

por Stanganello, Eliana, Zahavi, Eitan Erez, Burute, Mithila, Smits, Jasper, Jordens, Ingrid, Maurice, Madelon M., Kapitein, Lukas C., Hoogenraad, Casper C.
Publicado 2019

Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma

por Spaan, Ingrid, van Nieuwenhuijzen, Niels, Kimman, Thomas, Rockx-Brouwer, Dedeke, Tieland, Ralph G., Maurice, Madelon M., Minnema, Monique C., Raymakers, Reinier A., Peperzak, Victor
Publicado 2022

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

por Novellasdemunt, Laura, Kucharska, Anna, Jamieson, Cara, Prange‐Barczynska, Maria, Baulies, Anna, Antas, Pedro, van der Vaart, Jelte, Gehart, Helmuth, Maurice, Madelon M, Li, Vivian SW
Publicado 2019

mRNA spindle localization and mitotic translational regulation by CPEB1 and CPEB4

por Pascual, Rosa, Segura-Morales, Carolina, Omerzu, Manja, Bellora, Nicolás, Belloc, Eulàlia, Castellazzi, Chiara Lara, Reina, Oscar, Eyras, Eduardo, Maurice, Madelon M., Millanes-Romero, Alba, Méndez, Raúl
Publicado 2021

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

por Fenderico, Nicola, van Scherpenzeel, Revina C., Goldflam, Michael, Proverbio, Davide, Jordens, Ingrid, Kralj, Tomica, Stryeck, Sarah, Bass, Tarek Z., Hermans, Guy, Ullman, Christopher, Aastrup, Teodor, Gros, Piet, Maurice, Madelon M.
Publicado 2019

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

por Dubey, Ramin, van Kerkhof, Peter, Jordens, Ingrid, Malinauskas, Tomas, Pusapati, Ganesh V, McKenna, Joseph K, Li, Dan, Carette, Jan E, Ho, Mitchell, Siebold, Christian, Maurice, Madelon, Lebensohn, Andres M, Rohatgi, Rajat
Publicado 2020

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

por Colozza, Gabriele, Lee, Heetak, Merenda, Alessandra, Wu, Szu-Hsien Sam, Català-Bordes, Andrea, Radaszkiewicz, Tomasz W., Jordens, Ingrid, Lee, Ji-Hyun, Bamford, Aileen-Diane, Farnhammer, Fiona, Low, Teck Yew, Maurice, Madelon M., Bryja, Vítězslav, Kim, Jihoon, Koo, Bon-Kyoung
Publicado 2023

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

por Oost, Koen C., van Voorthuijsen, Lisa, Fumagalli, Arianna, Lindeboom, Rik G.H., Sprangers, Joep, Omerzu, Manja, Rodriguez-Colman, Maria J., Heinz, Maria C., Verlaan-Klink, Ingrid, Maurice, Madelon M., Burgering, Boudewijn M.T., van Rheenen, Jacco, Vermeulen, Michiel, Snippert, Hugo J.G.
Publicado 2018

TMEM59 potentiates Wnt signaling by promoting signalosome formation

por Gerlach, Jan P., Jordens, Ingrid, Tauriello, Daniele V. F., van ‘t Land-Kuper, Ineke, Bugter, Jeroen M., Noordstra, Ivar, van der Kooij, Johanneke, Low, Teck Y., Pimentel-Muiños, Felipe X., Xanthakis, Despina, Fenderico, Nicola, Rabouille, Catherine, Heck, Albert J. R., Egan, David A., Maurice, Madelon M.
Publicado 2018

RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer

por Spit, Maureen, Fenderico, Nicola, Jordens, Ingrid, Radaszkiewicz, Tomasz, Lindeboom, Rik GH, Bugter, Jeroen M, Cristobal, Alba, Ootes, Lars, van Osch, Max, Janssen, Eline, Boonekamp, Kim E, Hanakova, Katerina, Potesil, David, Zdrahal, Zbynek, Boj, Sylvia F, Medema, Jan Paul, Bryja, Vitezslav, Koo, Bon‐Kyoung, Vermeulen, Michiel, Maurice, Madelon M
Publicado 2020

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

por van der Krift, Felix, Zijlmans, Dick W, Shukla, Rhythm, Javed, Ali, Koukos, Panagiotis I, Schwarz, Laura LE, Timmermans-Sprang, Elpetra PM, Maas, Peter EM, Gahtory, Digvijay, van den Nieuwboer, Maurits, Mol, Jan A, Strous, Ger J, Bonvin, Alexandre MJJ, van der Stelt, Mario, Veldhuizen, Edwin JA, Weingarth, Markus, Vermeulen, Michiel, Klumperman, Judith, Maurice, Madelon M
Publicado 2023