The Many Spaces of uPAR: Delivery of Theranostic Agents and Nanobins to Multiple Tumor Compartments through a Single Target

por O'Halloran, Thomas V., Ahn, Richard, Hankins, Patrick, Swindell, Elden, Mazar, Andrew P.
Publicado 2013

The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma

por LEE, KRISTY, HART, MATTHEW R., BRIEHL, MARGARET M., MAZAR, ANDREW P., TOME, MARGARET E.
Publicado 2014

uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions

por Mahmood, Niaz, Arakelian, Ani, Khan, Haseeb Ahmed, Tanvir, Imrana, Mazar, Andrew P., Rabbani, Shafaat A.
Publicado 2020

GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents

por Karmali, Reem, Chukkapalli, Vineela, Gordon, Leo I., Borgia, Jeffrey A., Ugolkov, Andrey, Mazar, Andrew P., Giles, Francis J.
Publicado 2017

Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer

por Ugolkov, Andrey V., Matsangou, Maria, Taxter, Timothy J., O'Halloran, Thomas V., Cryns, Vincent L., Giles, Francis J., Mazar, Andrew P.
Publicado 2018

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

por Portelli, Michael A., Bhaker, Sangita, Pang, Vincent, Bates, David O., Johnson, Simon R., Mazar, Andrew P., Shaw, Dominick, Brightling, Christopher, Sayers, Ian
Publicado 2023

9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer

por Kuroki, Hiroo, Anraku, Tsutomu, Kazama, Akira, Bilim, Vladimir, Tasaki, Masayuki, Schmitt, Daniel, Mazar, Andrew P., Giles, Francis J, Ugolkov, Andrey, Tomita, Yoshihiko
Publicado 2019

Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors()

por Bondarenko, Gennadiy, Ugolkov, Andrey, Rohan, Stephen, Kulesza, Piotr, Dubrovskyi, Oleksii, Gursel, Demirkan, Mathews, Jeremy, O’Halloran, Thomas V., Wei, Jian J., Mazar, Andrew P.
Publicado 2015

Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study

por Boonstra, Martin C, Verbeek, Floris PR, Mazar, Andrew P, Prevoo, Hendrica AJM, Kuppen, Peter JK, van de Velde, Cornelis JH, Vahrmeijer, Alexander L, Sier, Cornelis FM
Publicado 2014

Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging

por Yang, Dongzhi, Severin, Gregory W., Dougherty, Casey A., Lombardi, Rachel, Chen, Daiqin, Van Dort, Marcian E., Barnhart, Todd E., Ross, Brian D., Mazar, Andrew P., Hong, Hao
Publicado 2016

Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models()()

por Ugolkov, Andrey, Qiang, Wenan, Bondarenko, Gennadiy, Procissi, Daniel, Gaisina, Irina, James, C. David, Chandler, James, Kozikowski, Alan, Gunosewoyo, Hendra, O'Halloran, Thomas, Raizer, Jeffrey, Mazar, Andrew P.
Publicado 2017

Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)

por Xu, Xiang, Cai, Yuan, Wei, Ying, Donate, Fernando, Juarez, Jose, Parry, Graham, Chen, Liqing, Meehan, Edward J., Ahn, Richard W., Ugolkov, Andrey, Dubrovskyi, Oleksii, O'Halloran, Thomas V., Huang, Mingdong, Mazar, Andrew P.
Publicado 2014

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells

por de Geus, Susanna WL, Baart, Victor M, Boonstra, Martin C, Kuppen, Peter JK, Prevoo, Hendrica AJM, Mazar, Andrew P, Bonsing, Bert A, Morreau, Hans, van de Velde, Cornelis JH, Vahrmeijer, Alexander L, Sier, Cornelis FM
Publicado 2017

Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors

por Baart, Victor M., van Manen, Labrinus, Bhairosingh, Shadhvi S., Vuijk, Floris A., Iamele, Luisa, de Jonge, Hugo, Scotti, Claudia, Resnati, Massimo, Cordfunke, Robert A., Kuppen, Peter J. K., Mazar, Andrew P., Burggraaf, Jacobus, Vahrmeijer, Alexander L., Sier, Cornelis F. M.
Publicado 2021

Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo

por Ahn, Richard W., Barrett, Susan L., Raja, Meera R., Jozefik, Jennifer K., Spaho, Lidia, Chen, Haimei, Bally, Marcel B., Mazar, Andrew P., Avram, Michael J., Winter, Jane N., Gordon, Leo I., Shea, Lonnie D., O’Halloran, Thomas V., Woodruff, Teresa K.
Publicado 2013

uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

por Boonstra, Martin C., van Driel, Pieter B.A.A., van Willigen, Danny M., Stammes, Marieke A., Prevoo, Hendrica A.J.M., Tummers, Quirijn R.J.G., Mazar, Andrew P., Beekman, Freek J., Kuppen, Peter J.K., van de Velde, Cornelis J.H., Löwik, Clemens W.G.M., Frangioni, John V., van Leeuwen, Fijs W.B., Sier, Cornelis F.M., Vahrmeijer, Alexander L.
Publicado 2015