Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue

por Stojkovska, Iva, Mazzulli, Joseph R.
Publicado 2021

Analysis of lysosomal hydrolase trafficking and activity in human iPSC-derived neuronal models

por Cuddy, Leah K., Mazzulli, Joseph R.
Publicado 2021

AAV9/MFSD8 gene therapy is effective in preclinical models of neuronal ceroid lipofuscinosis type 7 disease

por Chen, Xin, Dong, Thomas, Hu, Yuhui, Shaffo, Frances C., Belur, Nandkishore R., Mazzulli, Joseph R., Gray, Steven J.
Publicado 2022

Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway

por Cohen, Dena E., Cui, Libin, Supinski, Andrea, Savas, Jeffrey N., Mazzulli, Joseph R., Yates, John R., Bordone, Laura, Guarente, Leonard P., Krainc, Dimitri
Publicado 2011

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice

por Cuddy, Leah K., Alia, Alia O., Salvo, Miranda A., Chandra, Sidhanth, Grammatopoulos, Tom N., Justman, Craig J., Lansbury, Peter T., Mazzulli, Joseph R., Vassar, Robert
Publicado 2022

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

por Chung, Sun Young, Kishinevsky, Sarah, Mazzulli, Joseph R., Graziotto, John, Mrejeru, Ana, Mosharov, Eugene V., Puspita, Lesly, Valiulahi, Parvin, Sulzer, David, Milner, Teresa A., Taldone, Tony, Krainc, Dimitri, Studer, Lorenz, Shim, Jae-won
Publicado 2016

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

por Mor, Danielle E., Tsika, Elpida, Mazzulli, Joseph R., Gould, Neal S., Kim, Hanna, Daniels, Malcolm J., Doshi, Shachee, Gupta, Preetika, Grossman, Jennifer L., Tan, Victor X., Kalb, Robert G., Caldwell, Kim A., Caldwell, Guy A., Wolfe, John H., Ischiropoulos, Harry
Publicado 2017

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression

por Fagen, Sara J., Burgess, Jeremy D., Lim, Melina J., Amerna, Danilyn, Kaya, Zeynep B., Faroqi, Ayman H., Perisetla, Priyanka, DeMeo, Natasha N., Stojkovska, Iva, Quiriconi, Drew J., Mazzulli, Joseph R., Delenclos, Marion, Boschen, Suelen L., McLean, Pamela J.
Publicado 2023

CLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry

por Heinl, Elena-Sofia, Lorenz, Sebastian, Schmidt, Barbara, Nasser M Laqtom, Nouf, Mazzulli, Joseph R., Francelle, Laetitia, Yu, Timothy W., Greenberg, Benjamin, Storch, Stephan, Tegtmeier, Ines, Othmen, Helga, Maurer, Katja, Steinfurth, Malin, Witzgall, Ralph, Milenkovic, Vladimir, Wetzel, Christian H., Reichold, Markus
Publicado 2022

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models

por Prieto Huarcaya, Susy, Drobny, Alice, Marques, André R. A., Di Spiezio, Alessandro, Dobert, Jan Philipp, Balta, Denise, Werner, Christian, Rizo, Tania, Gallwitz, Lisa, Bub, Simon, Stojkovska, Iva, Belur, Nandkishore R., Fogh, Jens, Mazzulli, Joseph R, Xiang, Wei, Fulzele, Amitkumar, Dejung, Mario, Sauer, Markus, Winner, Beate, Rose-John, Stefan, Arnold, Philipp, Saftig, Paul, Zunke, Friederike
Publicado 2022