Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

por McAlary, Luke, Yerbury, Justin J.
Publicado 2019

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases

por McAlary, Luke, Plotkin, Steven S., Cashman, Neil R.
Publicado 2019

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

por McAlary, Luke, Yerbury, Justin J., Aquilina, J. Andrew
Publicado 2013

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

por McAlary, Luke, Aquilina, J. Andrew, Yerbury, Justin J.
Publicado 2016

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

por McAlary, Luke, Plotkin, Steven S., Yerbury, Justin J., Cashman, Neil R.
Publicado 2019

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

por McAlary, Luke, Plotkin, Steven S., Yerbury, Justin J., Cashman, Neil R.
Publicado 2020

Protocol for the generation and automated confocal imaging of whole multi-cellular tumor spheroids

por Genenger, Benjamin, McAlary, Luke, Perry, Jay R., Ashford, Bruce, Ranson, Marie
Publicado 2023

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

por Pokrishevsky, Edward, McAlary, Luke, Farrawell, Natalie E., Zhao, Beibei, Sher, Mine, Yerbury, Justin J., Cashman, Neil R.
Publicado 2018

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

por McAlary, Luke, Chew, Yee Lian, Lum, Jeremy Stephen, Geraghty, Nicholas John, Yerbury, Justin John, Cashman, Neil R.
Publicado 2020

Assessment of protein inclusions in cultured cells using automated image analysis

por McAlary, Luke, Shephard, Victoria K., Sher, Mine, Rice, Lauren J., Yerbury, Justin J., Cashman, Neil R., Plotkin, Steven S.
Publicado 2022

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

por Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.
Publicado 2020

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

por Farrawell, Natalie E., McAlary, Luke, Lum, Jeremy S., Chisholm, Christen G., Warraich, Sadaf T., Blair, Ian P., Vine, Kara L., Saunders, Darren N., Yerbury, Justin J.
Publicado 2020

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

por Capper, Michael J., Wright, Gareth S. A., Barbieri, Letizia, Luchinat, Enrico, Mercatelli, Eleonora, McAlary, Luke, Yerbury, Justin J., O’Neill, Paul M., Antonyuk, Svetlana V., Banci, Lucia, Hasnain, S. Samar
Publicado 2018

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis

por Farrawell, Natalie E, Bax, Monique, McAlary, Luke, McKenna, Jessie, Maksour, Simon, Do-Ha, Dzung, Rayner, Stephanie L, Blair, Ian P, Chung, Roger S, Yerbury, Justin J, Ooi, Lezanne, Saunders, Darren N
Publicado 2023

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

por Robert, Jerome, Button, Emily B., Martin, Emma M., McAlary, Luke, Gidden, Zoe, Gilmour, Megan, Boyce, Guilaine, Caffrey, Tara M., Agbay, Andrew, Clark, Amanda, Silverman, Judith M., Cashman, Neil R., Wellington, Cheryl L.
Publicado 2020

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1(G93A) mice with a C57BL/6 background

por Lum, Jeremy S., Brown, Mikayla L., Farrawell, Natalie E., McAlary, Luke, Ly, Diane, Chisholm, Christen G., Snow, Josh, Vine, Kara L., Karl, Tim, Kreilaus, Fabian, McInnes, Lachlan E., Nikseresht, Sara, Donnelly, Paul S., Crouch, Peter J., Yerbury, Justin J.
Publicado 2021