Identification of Candidate Small-Molecule Therapeutics to Cancer by Gene-Signature Perturbation in Connectivity Mapping

por McArt, Darragh G., Zhang, Shu-Dong
Publicado 2011

cudaMap: a GPU accelerated program for gene expression connectivity mapping

por McArt, Darragh G, Bankhead, Peter, Dunne, Philip D, Salto-Tellez, Manuel, Hamilton, Peter, Zhang, Shu-Dong
Publicado 2013

Novel deep learning-based solution for identification of prognostic subgroups in liver cancer (Hepatocellular carcinoma)

por Owens, Alice R., McInerney, Caitríona E., Prise, Kevin M., McArt, Darragh G., Jurek-Loughrey, Anna
Publicado 2021

Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer

por Hutchinson, Ryan A, Adams, Richard A, McArt, Darragh G, Salto-Tellez, Manuel, Jasani, Bharat, Hamilton, Peter W
Publicado 2015

Particle swarm optimization artificial intelligence technique for gene signature discovery in transcriptomic cohorts

por Murphy, Ross G., Gilmore, Alan, Senevirathne, Seedevi, O'Reilly, Paul G., LaBonte Wilson, Melissa, Jain, Suneil, McArt, Darragh G.
Publicado 2022

Connectivity Mapping for Candidate Therapeutics Identification Using Next Generation Sequencing RNA-Seq Data

por McArt, Darragh G., Dunne, Philip D., Blayney, Jaine K., Salto-Tellez, Manuel, Van Schaeybroeck, Sandra, Hamilton, Peter W., Zhang, Shu-Dong
Publicado 2013

KRAS mutant colorectal cancer gene signatures identified angiotensin II receptor blockers as potential therapies

por Wen, Qing, Dunne, Philip D., O’Reilly, Paul G., Li, Gerald, Bjourson, Anthony J., McArt, Darragh G., Hamilton, Peter W., Zhang, Shu-Dong
Publicado 2016

Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned

por Li, Gerald, Bankhead, Peter, Dunne, Philip D, O’Reilly, Paul G, James, Jacqueline A, Salto-Tellez, Manuel, Hamilton, Peter W, McArt, Darragh G
Publicado 2017

Quantification of HER2 heterogeneity in breast cancer–implications for identification of sub-dominant clones for personalised treatment

por Buckley, Niamh E., Forde, Claire, McArt, Darragh G., Boyle, David P., Mullan, Paul B., James, Jacqueline A., Maxwell, Perry, McQuaid, Stephen, Salto-Tellez, Manuel
Publicado 2016

Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis

por McCourt, Clare M., McArt, Darragh G., Mills, Ken, Catherwood, Mark A., Maxwell, Perry, Waugh, David J., Hamilton, Peter, O'Sullivan, Joe M., Salto-Tellez, Manuel
Publicado 2013

QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics

por O’Reilly, Paul G., Wen, Qing, Bankhead, Peter, Dunne, Philip D., McArt, Darragh G., McPherson, Suzanne, Hamilton, Peter W., Mills, Ken I., Zhang, Shu-Dong
Publicado 2016

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer

por Dunne, Philip D., O'Reilly, Paul G., Coleman, Helen G., Gray, Ronan T., Longley, Daniel B., Johnston, Patrick G., Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.
Publicado 2016

Prostate cancer heterogeneity assessment with multi-regional sampling and alignment-free methods

por Murphy, Ross G, Roddy, Aideen C, Srivastava, Shambhavi, Baena, Esther, Waugh, David J, M. O’Sullivan, Joe, McArt, Darragh G, Jain, Suneil, LaBonte, Melissa J
Publicado 2020

Transcriptional Profiling of a Patient-Matched Cohort of Glioblastoma (IDH-Wildtype) for Therapeutic Target and Repurposing Drug Identification

por Roddy, Aideen C., McInerney, Caitríona E., Flannery, Tom, Healy, Estelle G., Stewart, James P., Spence, Veronica J., Walsh, Jamie, Salto-Tellez, Manuel, McArt, Darragh G., Prise, Kevin M.
Publicado 2023

Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression

por O’Neill, Karla M., Irwin, Rachelle E., Mackin, Sarah-Jayne, Thursby, Sara-Jayne, Thakur, Avinash, Bertens, Ciske, Masala, Laura, Loughery, Jayne E. P., McArt, Darragh G., Walsh, Colum P.
Publicado 2018

NUQA: Estimating Cancer Spatial and Temporal Heterogeneity and Evolution through Alignment-Free Methods

por Roddy, Aideen C, Jurek-Loughrey, Anna, Souza, Jose, Gilmore, Alan, O’Reilly, Paul G, Stupnikov, Alexey, Gonzalez de Castro, David, Prise, Kevin M, Salto-Tellez, Manuel, McArt, Darragh G
Publicado 2019

Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

por Bibby, Becky A. S., Thiruthaneeswaran, Niluja, Yang, Lingjian, Pereira, Ronnie R., More, Elisabet, McArt, Darragh G., O’Reilly, Paul, Bristow, Robert G., Williams, Kaye J., Choudhury, Ananya, West, Catharine M. L.
Publicado 2021

A bespoke target selection tool to guide biomarker discovery in tubo-ovarian cancer

por Beirne, James P., Gilmore, Alan, McInerney, Caitríona E., Roddy, Aideen, Glenn McCluggage, W., Harley, Ian J.G., Abdullah Alvi, M., Prise, Kevin M., McArt, Darragh G., Mullan, Paul B.
Publicado 2022

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

por Bradley, Conor A., Dunne, Philip D., Bingham, Victoria, McQuaid, Stephen, Khawaja, Hajrah, Craig, Stephanie, James, Jackie, Moore, Wendy L., McArt, Darragh G., Lawler, Mark, Dasgupta, Sonali, Johnston, Patrick G., Van Schaeybroeck, Sandra
Publicado 2016

IHC-based subcellular quantification provides new insights into prognostic relevance of FLIP and procaspase-8 in non-small-cell lung cancer

por Hutchinson, Ryan A, Coleman, Helen G, Gately, Kathy, Young, Vincent, Nicholson, Siobhan, Cummins, Robert, Kay, Elaine, Hynes, Sean O, Dunne, Philip D, Senevirathne, Seedevi, Hamilton, Peter W, McArt, Darragh G, Longley, Daniel B
Publicado 2017