Beyond natural antibodies: the power of in vitro display technologies

por Bradbury, Andrew R.M., Sidhu, Sachdev, Dübel, Stefan, McCafferty, John
Publicado 2011

Basics of Antibody Phage Display Technology

por Ledsgaard, Line, Kilstrup, Mogens, Karatt-Vellatt, Aneesh, McCafferty, John, Laustsen, Andreas H.
Publicado 2018

Multiplexed expression and screening for recombinant protein production in mammalian cells

por Chapple, Susan DJ, Crofts, Anna M, Shadbolt, S Paul, McCafferty, John, Dyson, Michael R
Publicado 2006

Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression

por Dyson, Michael R, Shadbolt, S Paul, Vincent, Karen J, Perera, Rajika L, McCafferty, John
Publicado 2004

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

por Santamaria, Salvatore, Fedorov, Oleg, McCafferty, John, Murphy, Gillian, Dudhia, Jayesh, Nagase, Hideaki, Yamamoto, Kazuhiro
Publicado 2017

Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands

por Teng, Michelle S, Dekkers, Martijn PJ, Ng, Bee Ling, Rademakers, Suzanne, Jansen, Gert, Fraser, Andrew G, McCafferty, John
Publicado 2006

Identification of soluble protein fragments by gene fragmentation and genetic selection

por Dyson, Michael R., Perera, Rajika L., Shadbolt, S. Paul, Biderman, Lynn, Bromek, Krystyna, Murzina, Natalia V., McCafferty, John
Publicado 2008

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

por Santamaria, Salvatore, Yamamoto, Kazuhiro, Botkjaer, Kenneth, Tape, Christopher, Dyson, Michael R., McCafferty, John, Murphy, Gillian, Nagase, Hideaki
Publicado 2015

A simple vector system to improve performance and utilisation of recombinant antibodies

por Martin, Cecile D, Rojas, Gertrudis, Mitchell, Joanne N, Vincent, Karen J, Wu, Jiahua, McCafferty, John, Schofield, Darren J
Publicado 2006

Mapping protein interactions by combining antibody affinity maturation and mass spectrometry

por Dyson, Michael R., Zheng, Yong, Zhang, Cunjie, Colwill, Karen, Pershad, Kritika, Kay, Brian K., Pawson, Tony, McCafferty, John
Publicado 2011

Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells

por Falk, Ronny, Falk, Anna, Dyson, Michael R., Melidoni, Anna N., Parthiban, Kothai, Young, Joyce L., Roake, Wendy, McCafferty, John
Publicado 2012

A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing

por Parthiban, Kothai, Perera, Rajika L., Sattar, Maheen, Huang, Yanchao, Mayle, Sophie, Masters, Edward, Griffiths, Daniel, Surade, Sachin, Leah, Rachael, Dyson, Michael R., McCafferty, John
Publicado 2019

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

por Botkjaer, Kenneth A., Kwok, Hang Fai, Terp, Mikkel G., Karatt-Vellatt, Aneesh, Santamaria, Salvatore, McCafferty, John, Andreasen, Peter A., Itoh, Yoshifumi, Ditzel, Henrik J., Murphy, Gillian
Publicado 2016

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

por Dyson, Michael R., Masters, Edward, Pazeraitis, Deividas, Perera, Rajika L., Syrjanen, Johanna L., Surade, Sachin, Thorsteinson, Nels, Parthiban, Kothai, Jones, Philip C., Sattar, Maheen, Wozniak-Knopp, Gordana, Rueker, Florian, Leah, Rachael, McCafferty, John
Publicado 2020

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

por Laustsen, Andreas H., Karatt-Vellatt, Aneesh, Masters, Edward W., Arias, Ana Silvia, Pus, Urska, Knudsen, Cecilie, Oscoz, Saioa, Slavny, Peter, Griffiths, Daniel T., Luther, Alice M., Leah, Rachael A., Lindholm, Majken, Lomonte, Bruno, Gutiérrez, José María, McCafferty, John
Publicado 2018

Publisher Correction: In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

por Laustsen, Andreas H., Karatt-Vellatt, Aneesh, Masters, Edward W., Arias, Ana Silvia, Pus, Urska, Knudsen, Cecilie, Oscoz, Saioa, Slavny, Peter, Griffiths, Daniel T., Luther, Alice M., Leah, Rachael A., Lindholm, Majken, Lomonte, Bruno, Gutiérrez, José María, McCafferty, John
Publicado 2018

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

por DiCara, Danielle M., Chirgadze, Dimitri Y., Pope, Anthony R., Karatt-Vellatt, Aneesh, Winter, Anja, Slavny, Peter, van den Heuvel, Joop, Parthiban, Kothai, Holland, Jane, Packman, Len C., Mavria, Georgia, Hoffmann, Jens, Birchmeier, Walter, Gherardi, Ermanno, McCafferty, John
Publicado 2017

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

por Ledsgaard, Line, Wade, Jack, Jenkins, Timothy P., Boddum, Kim, Oganesyan, Irina, Harrison, Julian A., Villar, Pedro, Leah, Rachael A., Zenobi, Renato, Schoffelen, Sanne, Voldborg, Bjørn, Ljungars, Anne, McCafferty, John, Lomonte, Bruno, Gutiérrez, José M., Laustsen, Andreas H., Karatt-Vellatt, Aneesh
Publicado 2023

Assessing developability early in the discovery process for novel biologics

por Fernández-Quintero, Monica L., Ljungars, Anne, Waibl, Franz, Greiff, Victor, Andersen, Jan Terje, Gjølberg, Torleif T., Jenkins, Timothy P., Voldborg, Bjørn Gunnar, Grav, Lise Marie, Kumar, Sandeep, Georges, Guy, Kettenberger, Hubert, Liedl, Klaus R., Tessier, Peter M., McCafferty, John, Laustsen, Andreas H.
Publicado 2023

Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?

por Aungier, Susan R, Cartwright, Alison J, Schwenzer, Anja, Marshall, Jennifer L, Dyson, Michael R, Slavny, Peter, Parthiban, Kothai, Karatt-Vellatt, Aneesh, Sahbudin, Ilfita, Culbert, Eric, Hextall, Patrick, Clanchy, Felix IL, Williams, Richard, Marsden, Brian D, Raza, Karim, Filer, Andrew, Buckley, Christopher Dominic, McCafferty, John, Midwood, Kim S
Publicado 2019