Mutational Biases Influence Parallel Adaptation

por Stoltzfus, Arlin, McCandlish, David M.
Publicado 2017

Minimum epistasis interpolation for sequence-function relationships

por Zhou, Juannan, McCandlish, David M.
Publicado 2020

Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size

por Aguirre, Lyndsey, Hendelman, Anat, Hutton, Samuel F., McCandlish, David M., Lippman, Zachary B.
Publicado 2023

Selection for Protein Stability Enriches for Epistatic Interactions

por Posfai, Anna, Zhou, Juannan, Plotkin, Joshua B., Kinney, Justin B., McCandlish, David M.
Publicado 2018

Mutation bias shapes the spectrum of adaptive substitutions

por Cano, Alejandro V., Rozhoňová, Hana, Stoltzfus, Arlin, McCandlish, David M., Payne, Joshua L.
Publicado 2022

Evolutionary paths that link orthogonal pairs of binding proteins

por Avizemer, Ziv, Martí-Gómez, Carlos, Hoch, Shlomo Yakir, McCandlish, David M., Fleishman, Sarel J.
Publicado 2023

MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect

por Tareen, Ammar, Kooshkbaghi, Mahdi, Posfai, Anna, Ireland, William T., McCandlish, David M., Kinney, Justin B.
Publicado 2022

Mutation bias and the predictability of evolution

por Cano, Alejandro V., Gitschlag, Bryan L., Rozhoňová, Hana, Stoltzfus, Arlin, McCandlish, David M., Payne, Joshua L.
Publicado 2023

Higher-order epistasis and phenotypic prediction

por Zhou, Juannan, Wong, Mandy S., Chen, Wei-Chia, Krainer, Adrian R., Kinney, Justin B., McCandlish, David M.
Publicado 2022

Genomic and experimental evidence that ALK(ATI) does not predict single agent sensitivity to ALK inhibitors

por Inam, Haider, Sokirniy, Ivan, Rao, Yiyun, Shah, Anushka, Naeemikia, Farnaz, O'Brien, Edward, Dong, Cheng, McCandlish, David M., Pritchard, Justin R.
Publicado 2021

Designed active-site library reveals thousands of functional GFP variants

por Weinstein, Jonathan Yaacov, Martí-Gómez, Carlos, Lipsh-Sokolik, Rosalie, Hoch, Shlomo Yakir, Liebermann, Demian, Nevo, Reinat, Weissman, Haim, Petrovich-Kopitman, Ekaterina, Margulies, David, Ivankov, Dmitry, McCandlish, David M., Fleishman, Sarel J.
Publicado 2023