TCF7L2: the biggest story in diabetes genetics since HLA?

por Zeggini, E., McCarthy, M. I.
Publicado 2006

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

por Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., Zeggini, E.
Publicado 2009

Study profile: the Durban Diabetes Study (DDS): a platform for chronic disease research

por Hird, T. R., Young, E. H., Pirie, F. J., Riha, J., Esterhuizen, T. M., O'Leary, B., McCarthy, M. I., Sandhu, M. S., Motala, A. A.
Publicado 2016

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes

por Edghill, E L, Khamis, A, Weedon, M N, Walker, M, Hitman, G A, McCarthy, M I, Owen, K R, Ellard, S, T Hattersley, A, Frayling, T M
Publicado 2011

A common biological basis of obesity and nicotine addiction

por Thorgeirsson, T E, Gudbjartsson, D F, Sulem, P, Besenbacher, S, Styrkarsdottir, U, Thorleifsson, G, Walters, G B, Furberg, H, Sullivan, P F, Marchini, J, McCarthy, M I, Steinthorsdottir, V, Thorsteinsdottir, U, Stefansson, K
Publicado 2013

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes

por Herrera, B. M., Lockstone, H. E., Taylor, J. M., Ria, M., Barrett, A., Collins, S., Kaisaki, P., Argoud, K., Fernandez, C., Travers, M. E., Grew, J. P., Randall, J. C., Gloyn, A. L., Gauguier, D., McCarthy, M. I., Lindgren, C. M.
Publicado 2010

H3Africa multi-centre study of the prevalence and environmental and genetic determinants of type 2 diabetes in sub-Saharan Africa: study protocol

por Ekoru, K., Young, E. H., Adebamowo, C., Balde, N., Hennig, B. J., Kaleebu, P., Kapiga, S., Levitt, N. S., Mayige, M., Mbanya, J. C., McCarthy, M. I., Nyan, O., Nyirenda, M., Oli, J., Ramaiya, K., Smeeth, L., Sobngwi, E., Rotimi, C. N., Sandhu, M. S., Motala, A. A.
Publicado 2016

Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

por Wojciechowski, P., Lipowska, A., Rys, P., Ewens, K. G., Franks, S., Tan, S., Lerchbaum, E., Vcelak, J., Attaoua, R., Straczkowski, M., Azziz, R., Barber, T. M., Hinney, A., Obermayer-Pietsch, B., Lukasova, P., Bendlova, B., Grigorescu, F., Kowalska, I., Goodarzi, M. O., Strauss, J. F., McCarthy, M. I., Malecki, M. T.
Publicado 2012

Erratum to: Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis

por Wojciechowski, P., Lipowska, A., Rys, P., Ewens, K. G., Franks, S., Tan, S., Lerchbaum, E., Vcelak, J., Attaoua, R., Straczkowski, M., Azziz, R., Barber, T. M., Hinney, A., Obermayer-Pietsch, B., Lukasova, P., Bendlova, B., Grigorescu, F., Kowalska, I., Goodarzi, M. O., Strauss, J. F., McCarthy, M. I., Malecki, M. T.
Publicado 2012

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts

por van Leeuwen, N., Nijpels, G., Becker, M. L., Deshmukh, H., Zhou, K., Stricker, B. H. C., Uitterlinden, A. G., Hofman, A., van ’t Riet, E., Palmer, C. N. A., Guigas, B., Slagboom, P. E., Durrington, P., Calle, R. A., Neil, A., Hitman, G., Livingstone, S. J., Colhoun, H., Holman, R. R., McCarthy, M. I., Dekker, J. M., ’t Hart, L. M., Pearson, E. R.
Publicado 2012

Genetic association analysis of LARS2 with type 2 diabetes

por Reiling, E., Jafar-Mohammadi, B., van ’t Riet, E., Weedon, M. N., van Vliet-Ostaptchouk, J. V., Hansen, T., Saxena, R., van Haeften, T. W., Arp, P. A., Das, S., Nijpels, G., Groenewoud, M. J., van Hove, E. C., Uitterlinden, A. G., Smit, J. W. A., Morris, A. D., Doney, A. S. F., Palmer, C. N. A., Guiducci, C., Hattersley, A. T., Frayling, T. M., Pedersen, O., Slagboom, P. E., Altshuler, D. M., Groop, L., Romijn, J. A., Maassen, J. A., Hofker, M. H., Dekker, J. M., McCarthy, M. I., ’t Hart, L. M.
Publicado 2009

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

por Ma, R. C. W., Hu, C., Tam, C. H., Zhang, R., Kwan, P., Leung, T. F., Thomas, G. N., Go, M. J., Hara, K., Sim, X., Ho, J. S. K., Wang, C., Li, H., Lu, L., Wang, Y., Li, J. W., Wang, Y., Lam, V. K. L., Wang, J., Yu, W., Kim, Y. J., Ng, D. P., Fujita, H., Panoutsopoulou, K., Day-Williams, A. G., Lee, H. M., Ng, A. C. W., Fang, Y-J., Kong, A. P. S., Jiang, F., Ma, X., Hou, X., Tang, S., Lu, J., Yamauchi, T., Tsui, S. K. W., Woo, J., Leung, P. C., Zhang, X., Tang, N. L. S., Sy, H. Y., Liu, J., Wong, T. Y., Lee, J. Y., Maeda, S., Xu, G., Cherny, S. S., Chan, T. F., Ng, M. C. Y., Xiang, K., Morris, A. P., Keildson, S., Hu, R., Ji, L., Lin, X., Cho, Y. S., Kadowaki, T., Tai, E. S., Zeggini, E., McCarthy, M. I., Hon, K. L., Baum, L., Tomlinson, B., So, W. Y., Bao, Y., Chan, J. C. N., Jia, W.
Publicado 2013

A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2

por Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., Moustafa, J. S. El-Sayed, Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J. L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioshi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Deixheimer, M., Jonveaux, P., Leheup, B., Õunap, K., Bochukova, E. G., Henning, E., Keogh, J., Ellis, R. J., MacDermot, K. D., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R. F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M. I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M. E., O’Rahilly, S., Farooqi, I. S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A. J., Coin, L. J. M., Blakemore, A. I. F., Froguel, P., Beckmann, J. S.
Publicado 2010

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

por Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stančáková, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M., Groves, C. J., Gui, Y., Hallmans, G., Hattersley, A. T., He, K., Hitman, G. A., Holmkvist, J., Huang, S., Jiang, H., Jin, X., Justesen, J. M., Kristiansen, K., Kuusisto, J., Lajer, M., Lantieri, O., Li, W., Liang, H., Liao, Q., Liu, X., Ma, T., Ma, X., Manijak, M. P., Marre, M., Mokrosiński, J., Morris, A. D., Mu, B., Nielsen, A. A., Nijpels, G., Nilsson, P., Palmer, C. N. A., Rayner, N. W., Renström, F., Ribel-Madsen, R., Robertson, N., Rolandsson, O., Rossing, P., Schwartz, T. W., Slagboom, P. E., Sterner, M., Tang, M., Tarnow, L., Tuomi, T., van’t Riet, E., van Leeuwen, N., Varga, T. V., Vestmar, M. A., Walker, M., Wang, B., Wang, Y., Wu, H., Xi, F., Yengo, L., Yu, C., Zhang, X., Zhang, J., Zhang, Q., Zhang, W., Zheng, H., Zhou, Y., Altshuler, D., ‘t Hart, L. M., Franks, P. W., Balkau, B., Froguel, P., McCarthy, M. I., Laakso, M., Groop, L., Christensen, C., Brandslund, I., Lauritzen, T., Witte, D. R., Linneberg, A., Jørgensen, T., Hansen, T., Wang, J., Nielsen, R., Pedersen, O.
Publicado 2012