All Hands on Deck: Commensals, Th17 Cells, and Neutrophils Provide Short-term Compensation of Constitutive Permeability Defects Against Acute Infection

por McCole, Declan F.
Publicado 2017

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli

por Shawki, Ali, McCole, Declan F.
Publicado 2016

Epithelial-microbial diplomacy: escalating border tensions drive inflammation in inflammatory bowel disease

por King, Stephanie J, McCole, Declan F
Publicado 2019

JAK-STAT Pathway Regulation of Intestinal Permeability: Pathogenic Roles and Therapeutic Opportunities in Inflammatory Bowel Disease

por Lei, Hillmin, Crawford, Meli’sa S., McCole, Declan F.
Publicado 2021

A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa

por Kang, Sang Bum, Marchelletta, Ronald R, Penrose, Harrison, Docherty, Michael J, McCole, Declan F
Publicado 2015

A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function

por Alvarez, Rocio, Stork, Cheryl A., Sayoc-Becerra, Anica, Marchelletta, Ronald R., Prisk, G. Kim, McCole, Declan F.
Publicado 2019

Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis

por Morón, Belén, Spalinger, Marianne, Kasper, Stephanie, Atrott, Kirstin, Frey-Wagner, Isabelle, Fried, Michael, McCole, Declan F., Rogler, Gerhard, Scharl, Michael
Publicado 2013

A crucial role for HVEM and BTLA in preventing intestinal inflammation

por Steinberg, Marcos W., Turovskaya, Olga, Shaikh, Raziya B., Kim, Gisen, McCole, Declan F., Pfeffer, Klaus, Murphy, Kenneth M., Ware, Carl F., Kronenberg, Mitchell
Publicado 2008

Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence

por Spalinger, Marianne Rebecca, Shawki, Ali, Chatterjee, Pritha, Canale, Vinicius, Santos, Alina, Sayoc-Becerra, Anica, Scharl, Michael, Tremblay, Michel L, Borneman, James, McCole, Declan F
Publicado 2022

PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection

por Spalinger, Marianne R., Canale, Vinicius, Becerra, Anica, Shawki, Ali, Crawford, Meli’sa, Santos, Alina N., Chatterjee, Pritha, Li, Jiang, Nair, Meera G., McCole, Declan F.
Publicado 2023

Sa127 AN IBD-RISK VARIANT IN PTPN2 PROMOTES CELLULAR UPTAKE OF SARS-COV-2, WHICH IS MITIGATED BY THE JAK INHIBITOR TOFACITINIB

por Spalinger, Marianne, Hai, Rong, Li, Jiang, Nordgren, Tara M., Tremblay, Michel L, Eckmann, Lars, Hanson, Elaine M., Scharl, Michael M., Wu, Xiwei, Boland, Brigid, McCole, Declan F.
Publicado 2021

Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation

por Spalinger, Marianne R., Crawford, Meli’sa, Bobardt, Sarah D., Li, Jiang, Sayoc-Becerra, Anica, Santos, Alina N., Shawki, Ali, Chatterjee, Pritha, Nair, Meera G., McCole, Declan F.
Publicado 2021

The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn’s Disease but Not Ulcerative Colitis Patients

por Park, Young Su, Kang, Sang Bum, Marchelletta, Ronald R., Penrose, Harrison M., Ruiter-Visser, Roos, Jung, Barbara, Docherty, Michael J., Boland, Brigid S., Sandborn, William J., McCole, Declan F.
Publicado 2023

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

por Spalinger, Marianne R., Hai, Rong, Li, Jiang, Santos, Alina N., Nordgren, Tara M., Tremblay, Michel L., Eckmann, Lars, Hanson, Elaine, Scharl, Michael, Wu, Xiwei, Boland, Brigid S., McCole, Declan F.
Publicado 2020

Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue...

por Kozlova, Elena V., Carabelli, Bruno, Bishay, Anthony E., Liu, Rui, Denys, Maximillian E., Macbeth, John C., Piamthai, Varadh, Crawford, Meli’sa S., McCole, Declan F., zur Nieden, Nicole I., Hsiao, Ansel, Curras-Collazo, Margarita C.
Publicado 2022

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice

por Canale, Vinicius, Spalinger, Marianne R., Alvarez, Rocio, Sayoc-Becerra, Anica, Sanati, Golshid, Manz, Salomon, Chatterjee, Pritha, Santos, Alina N., Lei, Hillmin, Jahng, Sharon, Chu, Timothy, Shawki, Ali, Hanson, Elaine, Eckmann, Lars, Ouellette, André J., McCole, Declan F.
Publicado 2023

Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice

por Deol, Poonamjot, Ruegger, Paul, Logan, Geoffrey D., Shawki, Ali, Li, Jiang, Mitchell, Jonathan D., Yu, Jacqueline, Piamthai, Varadh, Radi, Sarah H., Hasnain, Sana, Borkowski, Kamil, Newman, John W., McCole, Declan F., Nair, Meera G., Hsiao, Ansel, Borneman, James, Sladek, Frances M.
Publicado 2023