Molecular insights into GPCR mechanisms for drugs of abuse

por Sanchez-Reyes, Omar B., Zilberg, Gregory, McCorvy, John D., Wacker, Daniel
Publicado 2023

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family

por Pigott, Adam, Frescas, Stewart, McCorvy, John D, Huang, Xi-Ping, Roth, Bryan L, Nichols, David E
Publicado 2012

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

por Chan, John D., McCorvy, John D., Acharya, Sreemoyee, Johns, Malcolm E., Day, Timothy A., Roth, Bryan L., Marchant, Jonathan S.
Publicado 2016

Structure-based discovery of potent and selective melatonin receptor agonists

por Patel, Nilkanth, Huang, Xi Ping, Grandner, Jessica M, Johansson, Linda C, Stauch, Benjamin, McCorvy, John D, Liu, Yongfeng, Roth, Bryan, Katritch, Vsevolod
Publicado 2020

Mu-opioid receptor selective superagonists produce prolonged respiratory depression

por Malcolm, Nicholas J., Palkovic, Barbara, Sprague, Daniel J., Calkins, Maggie M., Lanham, Janelle K., Halberstadt, Adam L., Stucke, Astrid G., McCorvy, John D.
Publicado 2023

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

por McCorvy, John D., Butler, Kyle V., Kelly, Brendan, Rechsteiner, Katie, Karpiak, Joel, Betz, Robin M., Kormos, Bethany L., Shoichet, Brian K., Dror, Ron O., Jin, Jian, Roth, Bryan L.
Publicado 2017

In silico design of novel probes for the atypical opioid receptor MRGPRX2

por Lansu, Katherine, Karpiak, Joel, Liu, Jing, Huang, Xi-Ping, McCorvy, John D., Kroeze, Wesley K., Che, Tao, Nagase, Hiroshi, Carroll, Frank I., Jin, Jian, Shoichet, Brian K., Roth, Bryan L.
Publicado 2017

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

por Chan, John D., Cupit, Pauline M., Gunaratne, Gihan S., McCorvy, John D., Yang, Yang, Stoltz, Kristen, Webb, Thomas R., Dosa, Peter I., Roth, Bryan L., Abagyan, Ruben, Cunningham, Charles, Marchant, Jonathan S.
Publicado 2017

“TRUPATH, an Open-Source Biosensor Platform for Interrogating the GPCR Transducerome”

por Olsen, Reid H.J., DiBerto, Jeffrey F., English, Justin G., Glaudin, Alexis M., Krumm, Brian E., Slocum, Samuel T., Che, Tao, Gavin, Ariana C., McCorvy, John D., Roth, Bryan L., Strachan, Ryan T.
Publicado 2020

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21

por Sahu, Bhavani S., Rodriguez, Pedro, Nguyen, Megin E., Han, Ruijun, Cero, Cheryl, Razzoli, Maria, Piaggi, Paolo, Laskowski, Lauren J., Pavlicev, Mihaela, Muglia, Louis, Mahata, Sushil K., O’Grady, Scott, McCorvy, John D., Baier, Leslie J., Sham, Yuk Y., Bartolomucci, Alessandro
Publicado 2019

Angiotensin AT(1A) receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity

por Balapattabi, Kirthikaa, Yavuz, Yavuz, Jiang, Jingwei, Deng, Guorui, Mathieu, Natalia M., Ritter, McKenzie L., Opichka, Megan A., Reho, John J., McCorvy, John D., Nakagawa, Pablo, Morselli, Lisa L., Mouradian, Gary C., Atasoy, Deniz, Cui, Huxing, Hodges, Matthew R., Sigmund, Curt D., Grobe, Justin L.
Publicado 2023

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

por Qin, Shanshan, Meng, Mengmeng, Yang, Dehua, Bai, Wenwen, Lu, Yan, Peng, Yao, Song, Gaojie, Wu, Yiran, Zhou, Qingtong, Zhao, Suwen, Huang, Xiping, McCorvy, John D., Cai, Xiaoqing, Dai, Antao, Roth, Bryan L., Hanson, Michael A., Liu, Zhi-Jie, Wang, Ming-Wei, Stevens, Raymond C., Shui, Wenqing
Publicado 2018

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

por Stein, Reed M., Kang, Hye Jin, McCorvy, John D., Glatfelter, Grant C., Jones, Anthony J., Che, Tao, Slocum, Samuel, Huang, Xi-Ping, Savych, Olena, Moroz, Yurii S., Stauch, Benjamin, Johansson, Linda C., Cherezov, Vadim, Kenakin, Terry, Irwin, John J., Shoichet, Brian K., Roth, Bryan L., Dubocovich, Margarita L.
Publicado 2020

Identification of 5-HT(2A) Receptor Signaling Pathways Responsible for Psychedelic Potential

por Wallach, Jason, Cao, Andrew B., Calkins, Maggie M., Heim, Andrew J., Lanham, Janelle K., Bonniwell, Emma M., Hennessey, Joseph J., Bock, Hailey A., Anderson, Emilie I., Sherwood, Alexander M., Morris, Hamilton, de Klein, Robbin, Klein, Adam K., Cuccurazzu, Bruna, Gamrat, James, Fannana, Tilka, Zauhar, Randy, Halberstadt, Adam L., McCorvy, John D.
Publicado 2023

XFEL structures of the human MT(2) melatonin receptor reveal basis of subtype selectivity

por Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, Shuming, Olsen, Reid H.J., Tribo, Alexandra R., Zaare, Sahba, Zhu, Lan, Zatsepin, Nadia A., Weierstall, Uwe, Yous, Saïd, Stevens, Raymond C., Liu, Wei, Roth, Bryan L., Katritch, Vsevolod, Cherezov, Vadim
Publicado 2019

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine

por Farrell, Martilias S., McCorvy, John D., Huang, Xi-Ping, Urban, Daniel J., White, Kate L., Giguere, Patrick M., Doak, Allison K., Bernstein, Alison I., Stout, Kristen A., Park, Su Mi, Rodriguiz, Ramona M., Gray, Bradley W., Hyatt, William S., Norwood, Andrew P., Webster, Kevin A., Gannon, Brenda M., Miller, Gary W., Porter, Joseph H., Shoichet, Brian K., Fantegrossi, William E., Wetsel, William C., Roth, Bryan L.
Publicado 2016

Structural basis for ligand recognition at the human MT(1) melatonin receptor

por Stauch, Benjamin, Johansson, Linda C., McCorvy, John D., Patel, Nilkanth, Han, Gye Won, Huang, Xi-Ping, Gati, Cornelius, Batyuk, Alexander, Slocum, Samuel T., Ishchenko, Andrii, Brehm, Wolfgang, White, Thomas A., Michaelian, Nairie, Madsen, Caleb, Zhu, Lan, Grant, Thomas D., Grandner, Jessica M., Shiriaeva, Anna, Olsen, Reid H.J., Tribo, Alexandra R., Yous, Saïd, Stevens, Raymond C., Weierstall, Uwe, Katritch, Vsevolod, Roth, Bryan L., Liu, Wei, Cherezov, Vadim
Publicado 2019

A Non-Hallucinogenic Psychedelic Analog with Therapeutic Potential

por Cameron, Lindsay P., Tombari, Robert J., Lu, Ju, Pell, Alexander J., Hurley, Zefan Q., Ehinger, Yann, Vargas, Maxemiliano V., McCarroll, Matthew N., Taylor, Jack C., Myers-Turnbull, Douglas, Liu, Taohui, Yaghoobi, Bianca, Laskowski, Lauren J., Anderson, Emilie I., Zhang, Guoliang, Viswanathan, Jayashri, Brown, Brandon M., Tjia, Michelle, Dunlap, Lee E., Rabow, Zachary T., Fiehn, Oliver, Wulff, Heike, McCorvy, John D., Lein, Pamela J., Kokel, David, Ron, Dorit, Peters, Jamie, Zuo, Yi, Olson, David E.
Publicado 2020