Dying to Survive—The p53 Paradox

por Lees, Andrea, Sessler, Tamas, McDade, Simon
Publicado 2021

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling

por Srivastava, Kirtiman, Pickard, Adam, McDade, Simon, McCance, Dennis J
Publicado 2015

Tumor suppressor p53: from engaging DNA to target gene regulation

por Sammons, Morgan A, Nguyen, Thuy-Ai T, McDade, Simon S, Fischer, Martin
Publicado 2020

Investigating the suitability of in vitro cell lines as models for the major subtypes of epithelial ovarian cancer

por McCabe, Aideen, Zaheed, Oza, McDade, Simon Samuel, Dean, Kellie
Publicado 2023

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

por Riege, Konstantin, Kretzmer, Helene, Sahm, Arne, McDade, Simon S, Hoffmann, Steve, Fischer, Martin
Publicado 2020

SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships

por Wappett, Mark, Harris, Adam, Lubbock, Alexander L R, Lobb, Ian, McDade, Simon, Overton, Ian M
Publicado 2021

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

por Pickard, Adam, McDade, Simon S., McFarland, Marie, McCluggage, W. Glenn, Wheeler, Cosette M., McCance, Dennis J.
Publicado 2015

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis

por Gorski, Julia J., Savage, Kienan I., Mulligan, Jude M., McDade, Simon S., Blayney, Jaine K., Ge, Zhaoping, Harkin, D. Paul
Publicado 2011

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells

por Cichon, Ann-Christin, Pickard, Adam, McDade, Simon S., Sharpe, Daniel J., Moran, Michael, James, Jacqueline A., McCance, Dennis J.
Publicado 2013

Functional and genetic analysis of the colon cancer network

por Emmert-Streib, Frank, de Matos Simoes, Ricardo, Glazko, Galina, McDade, Simon, Haibe-Kains, Benjamin, Holzinger, Andreas, Dehmer, Matthias, Campbell, Frederick Charles
Publicado 2014

VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer

por Poulose, Ninu, Forsythe, Nicholas, Polonski, Adam, Gregg, Gemma, Maguire, Sarah, Fuchs, Marc, Minner, Sarah, Sauter, Guido, McDade, Simon S., Mills, Ian G.
Publicado 2022

classifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes

por Quinn, Gerard P., Sessler, Tamas, Ahmaderaghi, Baharak, Lambe, Shauna, VanSteenhouse, Harper, Lawler, Mark, Wappett, Mark, Seligmann, Bruce, Longley, Daniel B., McDade, Simon S.
Publicado 2022

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

por Smith, James S., Lappin, Katrina M., Craig, Stephanie G., Liberante, Fabio G., Crean, Clare M., McDade, Simon S., Thompson, Alexander, Mills, Ken I., Savage, Kienan I.
Publicado 2020

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

por McDade, Simon S., Patel, Daksha, Moran, Michael, Campbell, James, Fenwick, Kerry, Kozarewa, Iwanka, Orr, Nicholas J., Lord, Christopher J., Ashworth, Alan A., McCance, Dennis J.
Publicado 2014

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

por Ferris, Jennifer, Espona-Fiedler, Margarita, Hamilton, Claudia, Holohan, Caitriona, Crawford, Nyree, McIntyre, Alex J., Roberts, Jamie Z., Wappett, Mark, McDade, Simon S., Longley, Daniel B., Coyle, Victoria
Publicado 2020

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

por McCann, Christopher, Crawford, Nyree, Majkut, Joanna, Holohan, Caitriona, Armstrong, Chris W. D., Maxwell, Pamela J., Ong, Chee Wee, LaBonte, Melissa J., McDade, Simon S., Waugh, David J., Longley, Daniel B.
Publicado 2018

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

por McDade, Simon S., Henry, Alexandra E., Pivato, Geraldine P., Kozarewa, Iwanka, Mitsopoulos, Constantinos, Fenwick, Kerry, Assiotis, Ioannis, Hakas, Jarle, Zvelebil, Marketa, Orr, Nicholas, Lord, Christopher J., Patel, Daksha, Ashworth, Alan, McCance, Dennis J.
Publicado 2012

A revised model of TRAIL‐R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

por Humphreys, Luke M, Fox, Jennifer P, Higgins, Catherine A, Majkut, Joanna, Sessler, Tamas, McLaughlin, Kirsty, McCann, Christopher, Roberts, Jamie Z, Crawford, Nyree T, McDade, Simon S, Scott, Christopher J, Harrison, Timothy, Longley, Daniel B
Publicado 2020

The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

por Roberts, Jamie Z., Holohan, Caitriona, Sessler, Tamas, Fox, Jennifer, Crawford, Nyree, Riley, Joel S., Khawaja, Hajrah, Majkut, Joanna, Evergren, Emma, Humphreys, Luke M., Ferris, Jennifer, Higgins, Catherine, Espona-Fiedler, Margarita, Moynagh, Paul, McDade, Simon S., Longley, Daniel B.
Publicado 2020

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

por Dunne, Philip D., Alderdice, Matthew, O'Reilly, Paul G., Roddy, Aideen C., McCorry, Amy M. B., Richman, Susan, Maughan, Tim, McDade, Simon S., Johnston, Patrick G., Longley, Daniel B., Kay, Elaine, McArt, Darragh G., Lawler, Mark
Publicado 2017