In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies

por McDermott, Martina, Eustace, Alex J., Busschots, Steven, Breen, Laura, Crown, John, Clynes, Martin, O’Donovan, Norma, Stordal, Britta
Publicado 2014

CDK7 Inhibition Is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition

por McDermott, Martina S. J., Sharko, Amanda C., Munie, Jessica, Kassler, Susannah, Melendez, Theresa, Lim, Chang-uk, Broude, Eugenia V.
Publicado 2020

HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells

por McDermott, Martina S. J., Conlon, Neil, Browne, Brigid C., Szabo, Adam, Synnott, Naoise C., O’Brien, Neil A., Duffy, Michael J., Crown, John, O’Donovan, Norma
Publicado 2019

The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

por Sharko, Amanda C., Lim, Chang-Uk, McDermott, Martina S. J., Hennes, Chuck, Philavong, Kingsavanh P., Aiken, Tiffanie, Tatarskiy, Victor V., Roninson, Igor B., Broude, Eugenia V.
Publicado 2021

Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy

por McDermott, Martina S. J., Browne, Brigid C., Conlon, Neil T., O’Brien, Neil A., Slamon, Dennis J., Henry, Michael, Meleady, Paula, Clynes, Martin, Dowling, Paul, Crown, John, O’Donovan, Norma
Publicado 2023

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy

por McDermott, Martina SJ, Browne, Brigid C, Conlon, Neil T, O’Brien, Neil A, Slamon, Dennis J, Henry, Michael, Meleady, Paula, Clynes, Martin, Dowling, Paul, Crown, John, O’Donovan, Norma
Publicado 2014

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

por McDermott, Martina S.J., Chumanevich, Alexander A., Lim, Chang-uk, Liang, Jiaxin, Chen, Mengqian, Altilia, Serena, Oliver, David, Rae, James M., Shtutman, Michael, Kiaris, Hippokratis, Győrffy, Balázs, Roninson, Igor B., Broude, Eugenia V.
Publicado 2017

Targeting activated PI3K/mTOR signaling overcomes acquired resistance to CDK4/6-based therapies in preclinical models of hormone receptor-positive breast cancer

por O’Brien, Neil A., McDermott, Martina S. J., Conklin, Dylan, Luo, Tong, Ayala, Raul, Salgar, Suruchi, Chau, Kevin, DiTomaso, Emmanuelle, Babbar, Naveen, Su, Faye, Gaither, Alex, Hurvitz, Sara A., Linnartz, Ronald, Rose, Kristine, Hirawat, Samit, Slamon, Dennis J.
Publicado 2020

Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy

por Gaynor, Nicola, Blanco, Alfonso, Madden, Stephen F., Moran, Barry, Fletcher, Jean M., Kaukonen, Damien, Ramírez, Javier Sánchez, Eustace, Alex J., McDermott, Martina S. J., Canonici, Alexandra, Toomey, Sinead, Teiserskiene, Ausra, Hennessy, Bryan T., O’Donovan, Norma, Crown, John, Collins, Denis M.
Publicado 2023

Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo

por Ding, Xiaokai, Sharko, Amanda C., McDermott, Martina S. J., Schools, Gary P., Chumanevich, Alexander, Ji, Hao, Li, Jing, Zhang, Li, Mack, Zachary T., Sikirzhytski, Vitali, Shtutman, Michael, Ivers, Laura, O’Donovan, Norma, Crown, John, Győrffy, Balázs, Chen, Mengqian, Roninson, Igor B., Broude, Eugenia V.
Publicado 2022

Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors

por McDermott, Martina S.J., O'Brien, Neil A., Hoffstrom, Benjamin, Gong, KeWei, Lu, Ming, Zhang, Jun, Luo, Tong, Liang, Min, Jia, Weiping, Hong, Jenny J., Chau, Kevin, Davenport, Simon, Xie, Bin, Press, Michael F., Panayiotou, Richard, Handly-Santana, Abram, Brugge, Joan S., Presta, Leonard, Glaspy, John, Slamon, Dennis J.
Publicado 2023

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

por Eustace, Alex J, Conlon, Neil T, McDermott, Martina S J, Browne, Brigid C, O’Leary, Patrick, Holmes, Frankie A, Espina, Virginia, Liotta, Lance A, O’Shaughnessy, Joyce, Gallagher, Clair, O’Driscoll, Lorraine, Rani, Sweta, Madden, Stephen F, O’Brien, Neil A, Ginther, Charles, Slamon, Dennis, Walsh, Naomi, Gallagher, William M, Zagozdzon, Radoslaw, Watson, William R, O’Donovan, Norma, Crown, John
Publicado 2018