Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

por Cobbaut, Mathias, McDonald, Neil Q., Parker, Peter J.
Publicado 2023

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL

por Mouilleron, Stephane, Guettler, Sebastian, Langer, Carola A, Treisman, Richard, McDonald, Neil Q
Publicado 2008

Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?

por Bax, Ben D., Sutormin, Dmitry, McDonald, Neil Q., Burley, Glenn A., Shelkovnikova, Tatyana
Publicado 2022

Fluorescence-based incision assay for human XPF–ERCC1 activity identifies important elements of DNA junction recognition

por Bowles, Maureen, Lally, John, Fadden, Andrew J., Mouilleron, Stephane, Hammonds, Timothy, McDonald, Neil Q.
Publicado 2012

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

por Rhymes, Elena R., Tosolini, Andrew P., Fellows, Alexander D., Mahy, William, McDonald, Neil Q., Schiavo, Giampietro
Publicado 2022

Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex

por Coulthard, Rachel, Deans, Andrew J., Swuec, Paolo, Bowles, Maureen, Costa, Alessandro, West, Stephen C., McDonald, Neil Q.
Publicado 2013

A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes

por Fadden, Andrew J., Schalbetter, Stephanie, Bowles, Maureen, Harris, Richard, Lally, John, Carr, Antony M., McDonald, Neil Q.
Publicado 2013

Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove

por Ivanova, Marina E., Fletcher, Georgina C., O’Reilly, Nicola, Purkiss, Andrew G., Thompson, Barry J., McDonald, Neil Q.
Publicado 2015

Molecular Recognition of the Tes LIM2–3 Domains by the Actin-related Protein Arp7A

por Boëda, Batiste, Knowles, Phillip P., Briggs, David C., Murray-Rust, Judith, Soriano, Erika, Garvalov, Boyan K., McDonald, Neil Q., Way, Michael
Publicado 2011

Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans

por Plaza-Menacho, Iván, Barnouin, Karin, Goodman, Kerry, Martínez-Torres, Rubén J., Borg, Annabel, Murray-Rust, Judith, Mouilleron, Stephane, Knowles, Phillip, McDonald, Neil Q.
Publicado 2014

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

por Plaza-Menacho, Iván, Barnouin, Karin, Barry, Rachael, Borg, Annabel, Orme, Mariam, Chauhan, Rakhee, Mouilleron, Stephane, Martínez-Torres, Rubén J., Meier, Pascal, McDonald, Neil Q.
Publicado 2016

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

por Jones, Morgan, Beuron, Fabienne, Borg, Aaron, Nans, Andrea, Earl, Christopher P., Briggs, David C., Snijders, Ambrosius P., Bowles, Maureen, Morris, Edward P., Linch, Mark, McDonald, Neil Q.
Publicado 2020

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

por Martini, Silvia, Davis, Khalil, Faraway, Rupert, Elze, Lisa, Lockwood, Nicola, Jones, Andrew, Xie, Xiao, McDonald, Neil Q., Mann, David J., Armstrong, Alan, Ule, Jernej, Parker, Peter J.
Publicado 2021

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

por Moccia, Marialuisa, Frett, Brendan, Zhang, Lingtian, Lakkaniga, Naga Rajiv, Briggs, David C., Chauhan, Rakhee, Brescia, Annalisa, Federico, Giorgia, Yan, Wei, Santoro, Massimo, McDonald, Neil Q., Li, Hong-yu, Carlomagno, Francesca
Publicado 2020

The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity

por Elbediwy, Ahmed, Zhang, Yixiao, Cobbaut, Mathias, Riou, Philippe, Tan, Ray S., Roberts, Selene K., Tynan, Chris, George, Roger, Kjaer, Svend, Martin-Fernandez, Marisa L., Thompson, Barry J., McDonald, Neil Q., Parker, Peter J.
Publicado 2019

Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention

por Watson, Lisa, Soliman, Tanya N., Davis, Khalil, Kelly, Joanna, Lockwood, Nicola, Yang, Xiaoping, Lynham, Steven, Scott, John D., Crossland, Victoria, McDonald, Neil Q., Mann, David J., Armstrong, Alan, Eggert, Ulrike, Parker, Peter J.
Publicado 2021

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

por Riou, Philippe, Kjær, Svend, Garg, Ritu, Purkiss, Andrew, George, Roger, Cain, Robert J., Bineva, Ganka, Reymond, Nicolas, McColl, Brad, Thompson, Andrew J., O’Reilly, Nicola, McDonald, Neil Q., Parker, Peter J., Ridley, Anne J.
Publicado 2013

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

por Riou, Philippe, Kjær, Svend, Garg, Ritu, Purkiss, Andrew, George, Roger, Cain, Robert J., Bineva, Ganka, Reymond, Nicolas, McColl, Brad, Thompson, Andrew J., O’Reilly, Nicola, McDonald, Neil Q., Parker, Peter J., Ridley, Anne J.
Publicado 2013

A secondary RET mutation in the activation loop conferring resistance to vandetanib

por Nakaoku, Takashi, Kohno, Takashi, Araki, Mitsugu, Niho, Seiji, Chauhan, Rakhee, Knowles, Phillip P., Tsuchihara, Katsuya, Matsumoto, Shingo, Shimada, Yoko, Mimaki, Sachiyo, Ishii, Genichiro, Ichikawa, Hitoshi, Nagatoishi, Satoru, Tsumoto, Kouhei, Okuno, Yasushi, Yoh, Kiyotaka, McDonald, Neil Q., Goto, Koichi
Publicado 2018

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

por Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.
Publicado 2021