Cytokine generation, promoter activation, and oxidant-independent NF-κB activation in a transfectable human neutrophilic cellular model

por Ear, Thornin, McDonald, Patrick P
Publicado 2008

Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways

por Tatsiy, Olga, McDonald, Patrick P.
Publicado 2018

Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus

por de Carvalho Oliveira, Vanessa, Tatsiy, Olga, McDonald, Patrick P.
Publicado 2023

Regulation of Discrete Functional Responses by Syk and Src Family Tyrosine Kinases in Human Neutrophils

por Ear, Thornin, Tatsiy, Olga, Allard, Frédérick L., McDonald, Patrick P.
Publicado 2017

Airway Mucins Inhibit Oxidative and Non-Oxidative Bacterial Killing by Human Neutrophils

por Cantin, André M., Ouellet, Cristine, Cloutier, Alexandre, McDonald, Patrick P.
Publicado 2020

Early and Late Processes Driving NET Formation, and the Autocrine/Paracrine Role of Endogenous RAGE Ligands

por Tatsiy, Olga, de Carvalho Oliveira, Vanessa, Mosha, Hugo Tshivuadi, McDonald, Patrick P.
Publicado 2021

New Insights into the Pro-Inflammatory Activities of Ang1 on Neutrophils: Induction of MIP-1β Synthesis and Release

por Dumas, Elizabeth, Neagoe, Paul-Eduard, McDonald, Patrick P., White, Michel, Sirois, Martin G.
Publicado 2016

Human Neutrophils Generate Extracellular Vesicles That Modulate Their Functional Responses

por Hurtado Gutiérrez, María José, Allard, Frédérick L., Mosha, Hugo Tshivuadi, Dubois, Claire M., McDonald, Patrick P.
Publicado 2022

The Chicken Chorioallantoic Membrane Tumor Assay as a Relevant In Vivo Model to Study the Impact of Hypoxia on Tumor Progression and Metastasis

por Harper, Kelly, Yatsyna, Anna, Charbonneau, Martine, Brochu-Gaudreau, Karine, Perreault, Alexis, Jeldres, Claudio, McDonald, Patrick P., Dubois, Claire M.
Publicado 2021

Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk

por Tatsiy, Olga, Mayer, Thomas Z., de Carvalho Oliveira, Vanessa, Sylvain-Prévost, Stéphanie, Isabel, Marilyn, Dubois, Claire M., McDonald, Patrick P.
Publicado 2020

Establishment of a ccRCC patient-derived chick chorioallantoic membrane model for drug testing

por Charbonneau, Martine, Harper, Kelly, Brochu-Gaudreau, Karine, Perreault, Alexis, McDonald, Patrick P., Ekindi-Ndongo, Nadia, Jeldres, Claudio, Dubois, Claire M.
Publicado 2022

Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells

por Guindi, Chantal, Cloutier, Alexandre, Gaudreau, Simon, Zerif, Echarki, McDonald, Patrick P., Tatsiy, Olga, Asselin, Claude, Dupuis, Gilles, Gris, Denis, Amrani, Abdelaziz
Publicado 2018

Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice

por Chen, Kuan-Ju, Zhang, Jimin, LaSala, Daniel, Basso, Jessica, Chun, Donald, Zhou, Yuchen, McDonald, Patrick P., Perkins, Walter R., Cipolla, David C.
Publicado 2023

Brensocatib (an oral, reversible inhibitor of dipeptidyl peptidase-1) attenuates disease progression in two animal models of rheumatoid arthritis

por McDonald, Patrick P., Leifer, Franziska Graf, Basso, Jessica, Lasala, Dan, Li, Dedong, Chen, Kuan-Ju, Zhang, Jimin, Perkins, Walter R., Cipolla, David C.
Publicado 2023

The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species

por Basso, Jessica, Chen, Kuan-Ju, Zhou, Yuchen, Mark, Lilly, LaSala, Daniel, Dorfman, Arielle, Atalla, Mary, Chun, Donald, Viramontes, Veronica, Chang, Christina, Leifer, Franziska, McDonald, Patrick P., Cipolla, David C.
Publicado 2023