New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis

por McDonald, Paul C., Dedhar, Shoukat
Publicado 2022

Coordinated Regulation of Metabolic Transporters and Migration/Invasion by Carbonic Anhydrase IX

por McDonald, Paul C., Swayampakula, Mridula, Dedhar, Shoukat
Publicado 2018

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

por McDonald, Paul C., Chafe, Shawn C., Dedhar, Shoukat
Publicado 2016

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

por McDonald, Paul C., Winum, Jean-Yves, Supuran, Claudiu T., Dedhar, Shoukat
Publicado 2012

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

por McDonald, Paul C., Chafe, Shawn C., Supuran, Claudiu T., Dedhar, Shoukat
Publicado 2022

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

por Serrano, Isabel, McDonald, Paul C., Lock, Frances, Muller, William J., Dedhar, Shoukat
Publicado 2013

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

por Fielding, Andrew B., Dobreva, Iveta, McDonald, Paul C., Foster, Leonard J., Dedhar, Shoukat
Publicado 2008

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

por Hedlund, Eva-Maria E., McDonald, Paul C., Nemirovsky, Oksana, Awrey, Shannon, Jensen, Lasse D.E., Dedhar, Shoukat
Publicado 2019

A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells

por Al-Ghabkari, Abdulhameed, Deng, Jing-Ti, McDonald, Paul C., Dedhar, Shoukat, Alshehri, Mana, Walsh, Michael P., MacDonald, Justin A.
Publicado 2016

A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells

por Venkateswaran, Geetha, McDonald, Paul C., Chafe, Shawn C., Brown, Wells S., Gerbec, Zachary J., Awrey, Shannon J., Parker, Seth J., Dedhar, Shoukat
Publicado 2023

β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells

por Mousavizadeh, Rouhollah, Hojabrpour, Payman, Eltit, Felipe, McDonald, Paul C., Dedhar, Shoukat, McCormack, Robert G., Duronio, Vincent, Jafarnejad, Seyed Mehdi, Scott, Alex
Publicado 2020

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

por McDonald, Paul C., Chia, Stephen, Bedard, Philippe L., Chu, Quincy, Lyle, Michael, Tang, Liren, Singh, Madhu, Zhang, Zaihui, Supuran, Claudiu T., Renouf, Daniel J., Dedhar, Shoukat
Publicado 2020

Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

por Brown, Wells S., McDonald, Paul C., Nemirovsky, Oksana, Awrey, Shannon, Chafe, Shawn C., Schaeffer, David F., Li, Jinyang, Renouf, Daniel J., Stanger, Ben Z., Dedhar, Shoukat
Publicado 2020

Integrin-Linked Kinase Is a Functional Mn(2+)-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation

por Maydan, Mykola, McDonald, Paul C., Sanghera, Jasbinder, Yan, Jun, Rallis, Charalampos, Pinchin, Sheena, Hannigan, Gregory E., Foster, Leonard J., Ish-Horowicz, David, Walsh, Michael P., Dedhar, Shoukat
Publicado 2010

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

por Brasher, Megan I., Chafe, Shawn C., McDonald, Paul C., Nemirovsky, Oksana, Gorshtein, Genya, Gerbec, Zachary J., Brown, Wells S., Grafinger, Olivia R., Marchment, Matthew, Matus, Esther, Dedhar, Shoukat, Coppolino, Marc G.
Publicado 2022

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells

por Kharbili, Manale El, Robert, Clément, Witkowski, Tiffany, Danty-Berger, Emmanuelle, Barbollat-Boutrand, Laetitia, Masse, Ingrid, Gadot, Nicolas, de la Fouchardière, Arnaud, McDonald, Paul C, Dedhar, Shoukat, Le Naour, François, Degoul, Françoise, Berthier-Vergnes, Odile
Publicado 2017

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

por Chafe, Shawn C., Vizeacoumar, Frederick S., Venkateswaran, Geetha, Nemirovsky, Oksana, Awrey, Shannon, Brown, Wells S., McDonald, Paul C., Carta, Fabrizio, Metcalfe, Andrew, Karasinska, Joanna M., Huang, Ling, Muthuswamy, Senthil K., Schaeffer, David F., Renouf, Daniel J., Supuran, Claudiu T., Vizeacoumar, Franco J., Dedhar, Shoukat
Publicado 2021

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

por Sheff, Joey G., Kelly, John F., Robotham, Anna, Sulea, Traian, Malenfant, Félix, L’Abbé, Denis, Duchesne, Mélanie, Pelletier, Alex, Lefebvre, Jean, Acel, Andrea, Parat, Marie, Gosselin, Mylene, Wu, Cunle, Fortin, Yves, Baardsnes, Jason, Van Faassen, Henk, Awrey, Shannon, Chafe, Shawn C., McDonald, Paul C., Dedhar, Shoukat, Lenferink, Anne E.G.
Publicado 2021

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

por Lenferink, Anne E.G., McDonald, Paul C., Cantin, Christiane, Grothé, Suzanne, Gosselin, Mylene, Baardsnes, Jason, Banville, Myriam, Lachance, Paul, Robert, Alma, Cepero-Donates, Yuneivy, Radinovic, Stevo, Salois, Patrick, Parat, Marie, Oamari, Hafida, Dulude, Annie, Patel, Mehul, Lafrance, Martin, Acel, Andrea, Bousquet-Gagnon, Nathalie, L’Abbé, Denis, Pelletier, Alex, Malenfant, Félix, Jaramillo, Maria, O’Connor-Mccourt, Maureen, Wu, Cunle, Durocher, Yves, Duchesne, Mélanie, Gadoury, Christine, Marcil, Anne, Fortin, Yves, Paul-Roc, Beatrice, Acchione, Maurizio, Chafe, Shawn C., Nemirovsky, Oksana, Lau, Joseph, Bénard, Francois, Dedhar, Shoukat
Publicado 2021