Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy

por Pettinati, Ilaria, Brem, Jürgen, McDonough, Michael A., Schofield, Christopher J.
Publicado 2015

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

por Brewitz, Lennart, Tumber, Anthony, Pfeffer, Inga, McDonough, Michael A., Schofield, Christopher J.
Publicado 2020

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

por Brewitz, Lennart, Tumber, Anthony, Pfeffer, Inga, McDonough, Michael A., Schofield, Christopher J.
Publicado 2020

Mechanisms of substrate recognition and N(6)-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes

por Kaur, Simranjeet, Tam, Nok Yin, McDonough, Michael A, Schofield, Christopher J, Aik, Wei Shen
Publicado 2022

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

por Aik, WeiShen, Scotti, John S., Choi, Hwanho, Gong, Lingzhi, Demetriades, Marina, Schofield, Christopher J., McDonough, Michael A.
Publicado 2014

Use of ferrous iron by metallo-β-lactamases

por Cahill, Samuel T., Tarhonskaya, Hanna, Rydzik, Anna M., Flashman, Emily, McDonough, Michael A., Schofield, Christopher J., Brem, Jürgen
Publicado 2016

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

por Islam, Md. Saiful, McDonough, Michael A., Chowdhury, Rasheduzzaman, Gault, Joseph, Khan, Amjad, Pires, Elisabete, Schofield, Christopher J.
Publicado 2019

Human Oxygenase Variants Employing a Single Protein Fe(II) Ligand Are Catalytically Active

por Brasnett, Amelia, Pfeffer, Inga, Brewitz, Lennart, Chowdhury, Rasheduzzaman, Nakashima, Yu, Tumber, Anthony, McDonough, Michael A., Schofield, Christopher J.
Publicado 2021

Inhibition of JMJD6 by 2‐Oxoglutarate Mimics

por Islam, Md. Sailful, Thinnes, Cyrille C., Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, McDonough, Michael A., Schofield, Christopher J.
Publicado 2021

Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids**

por Rydzik, Anna M, Leung, Ivanhoe K H, Kochan, Grazyna T, McDonough, Michael A, Claridge, Timothy D W, Schofield, Christopher J
Publicado 2014

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens

por Lippl, Kerstin, Boleininger, Anna, McDonough, Michael A, Abboud, Martine I, Tarhonskaya, Hanna, Chowdhury, Rasheduzzaman, Loenarz, Christoph, Schofield, Christopher J
Publicado 2018

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

por Lucic, Anka, Malla, Tika R., Calvopiña, Karina, Tooke, Catherine L., Brem, Jürgen, McDonough, Michael A., Spencer, James, Schofield, Christopher J.
Publicado 2022

In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery

por Li, Zhihong, Wu, Yue, Zhen, Shuai, Su, Kaijun, Zhang, Linjian, Yang, Fulai, McDonough, Michael A., Schofield, Christopher J., Zhang, Xiaojin
Publicado 2022

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

por Pettinati, Ilaria, Grzechnik, Pawel, Ribeiro de Almeida, Claudia, Brem, Jurgen, McDonough, Michael A, Dhir, Somdutta, Proudfoot, Nick J, Schofield, Christopher J
Publicado 2018

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

por Holt-Martyn, James P., Tumber, Anthony, Rahman, Mohammed Z., Lippl, Kerstin, Figg, William, McDonough, Michael A., Chowdhury, Rasheduzzaman, Schofield, Christopher J.
Publicado 2019

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat

por Figg, William D., McDonough, Michael A., Chowdhury, Rasheduzzaman, Nakashima, Yu, Zhang, Zhihong, Holt‐Martyn, James P., Krajnc, Alen, Schofield, Christopher J.
Publicado 2021

Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases

por Horita, Shoichiro, Scotti, John S., Thinnes, Cyrille, Mottaghi-Taromsari, Yousef S., Thalhammer, Armin, Ge, Wei, Aik, WeiShen, Loenarz, Christoph, Schofield, Christopher J., McDonough, Michael A.
Publicado 2015

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

por Brem, Jürgen, van Berkel, Sander S., Zollman, David, Lee, Sook Y., Gileadi, Opher, McHugh, Peter J., Walsh, Timothy R., McDonough, Michael A., Schofield, Christopher J.
Publicado 2015

YcfD(RM) is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase

por Sekirnik, Rok, Wilkins, Sarah E., Bush, Jacob, Tarhonskaya, Hanna, Münzel, Martin, Hussein, Aayan, Flashman, Emily, Mohammed, Shabaz, McDonough, Michael A., Loenarz, Christoph, Schofield, Christopher J.
Publicado 2018

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

por Makena, Anne, Düzgün, Azer Ö., Brem, Jürgen, McDonough, Michael A., Rydzik, Anna M., Abboud, Martine I., Saral, Ayşegül, Çiçek, Ayşegül Ç., Sandalli, Cemal, Schofield, Christopher J.
Publicado 2016