Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

por Yuzwa, Scott A, Shan, Xiaoyang, Jones, Bryan A, Zhao, Gang, Woodward, Melissa L, Li, Xiaojing, Zhu, Yanping, McEachern, Ernest J, Silverman, Michael A, Watson, Neil V, Gong, Cheng-Xin, Vocadlo, David J
Publicado 2014

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

por Hastings, Nicholas B., Wang, Xiaohai, Song, Lixin, Butts, Brent D., Grotz, Diane, Hargreaves, Richard, Fred Hess, J., Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X., Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J., Ouyang, Xuesong, Rosahl, Thomas W., Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J., Wang, Ganfeng, Duffy, Joseph L., Parker, Eric M., Zhang, Lili
Publicado 2017