Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective

por Rainard, Julie M., Pandarakalam, George C., McElroy, Stuart P.
Publicado 2018

Burkholderia pseudomallei d‐alanine‐d‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target

por Díaz‐Sáez, Laura, Torrie, Leah S., McElroy, Stuart P., Gray, David, Hunter, William N.
Publicado 2019

Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants

por Monaghan, Amy E., Porter, Alison, Hunter, Irene., Morrison, Angus, McElroy, Stuart P., McEwan, Iain J.
Publicado 2022

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

por McElroy, Stuart P., Nomura, Toshifumi, Torrie, Leah S., Warbrick, Emma, Gartner, Ulrike, Wood, Gavin, McLean, W. H. Irwin
Publicado 2013

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

por Parnell, Euan, Koschinski, Andreas, Zaccolo, Manuela, Cameron, Ryan T., Baillie, George S., Baillie, Gemma L., Porter, Alison, McElroy, Stuart P., Yarwood, Stephen J.
Publicado 2015

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

por Parnell, Euan, McElroy, Stuart P., Wiejak, Jolanta, Baillie, Gemma L., Porter, Alison, Adams, David R., Rehmann, Holger, Smith, Brian O., Yarwood, Stephen J.
Publicado 2017

The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

por Zachari, Maria, Rainard, Julie M., Pandarakalam, George C., Robinson, Lindsay, Gillespie, Jonathan, Rajamanickam, Muralikrishnan, Hamon, Veronique, Morrison, Angus, Ganley, Ian G., McElroy, Stuart P.
Publicado 2020

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

por Gardner, Nicola J., Gillespie, Peter J., Carrington, Jamie T., Shanks, Emma J., McElroy, Stuart P., Haagensen, Emma J., Frearson, Julie A., Woodland, Andrew, Blow, J. Julian
Publicado 2017

Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84

por Jenkins, Laura, Marsango, Sara, Mancini, Sarah, Mahmud, Zobaer Al, Morrison, Angus, McElroy, Stuart P., Bennett, Kirstie A., Barnes, Matt, Tobin, Andrew B., Tikhonova, Irina G., Milligan, Graeme
Publicado 2021

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)

por Heap, Rachel E., Hope, Anthony G., Pearson, Lesley-Anne, Reyskens, Kathleen M. S. E., McElroy, Stuart P., Hastie, C. James, Porter, David W., Arthur, J. Simon C., Gray, David W., Trost, Matthias
Publicado 2017

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

por Bayliss, Tracy, Robinson, David A., Smith, Victoria C., Brand, Stephen, McElroy, Stuart P., Torrie, Leah S., Mpamhanga, Chido, Norval, Suzanne, Stojanovski, Laste, Brenk, Ruth, Frearson, Julie A., Read, Kevin D., Gilbert, Ian H., Wyatt, Paul G.
Publicado 2017

Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6

por De Vita, Elena, Smits, Niels, van den Hurk, Helma, Beck, Elizabeth M., Hewitt, Joanne, Baillie, Gemma, Russell, Emily, Pannifer, Andrew, Hamon, Véronique, Morrison, Angus, McElroy, Stuart P., Jones, Philip, Ignatenko, Natalia A., Gunkel, Nikolas, Miller, Aubry K.
Publicado 2019

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

por Brand, Stephen, Cleghorn, Laura A. T., McElroy, Stuart P., Robinson, David A., Smith, Victoria C., Hallyburton, Irene, Harrison, Justin R., Norcross, Neil R., Spinks, Daniel, Bayliss, Tracy, Norval, Suzanne, Stojanovski, Laste, Torrie, Leah S., Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Read, Kevin D., Wyatt, Paul G., Gilbert, Ian H.
Publicado 2011

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Tre...

por Brand, Stephen, Norcross, Neil R., Thompson, Stephen, Harrison, Justin R., Smith, Victoria C., Robinson, David A., Torrie, Leah S., McElroy, Stuart P., Hallyburton, Irene, Norval, Suzanne, Scullion, Paul, Stojanovski, Laste, Simeons, Frederick R. C., van Aalten, Daan, Frearson, Julie A., Brenk, Ruth, Fairlamb, Alan H., Ferguson, Michael A. J., Wyatt, Paul G., Gilbert, Ian H., Read, Kevin D.
Publicado 2014

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

por Frearson, Julie A., Brand, Stephen, McElroy, Stuart P., Cleghorn, Laura A.T., Smid, Ondrej, Stojanovski, Laste, Price, Helen P., Guther, M. Lucia S., Torrie, Leah S., Robinson, David A., Hallyburton, Irene, Mpamhanga, Chidochangu P., Brannigan, James A., Wilkinson, Anthony J., Hodgkinson, Michael, Hui, Raymond, Qiu, Wei, Raimi, Olawale G., van Aalten, Daan M. F., Brenk, Ruth, Gilbert, Ian H., Read, Kevin D., Fairlamb, Alan H., Ferguson, Michael A. J., Smith, Deborah F., Wyatt, Paul G.
Publicado 2010