Detection and destruction of antibody-bound viruses by TRIM21

por McEwan, William
Publicado 2013

Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21

por McEwan, William A.
Publicado 2016

Antibodies in the intracellular domain

por McEwan, William A.
Publicado 2022

The Lingering Effects of an Artificial Blind Spot

por Morgan, Michael J., McEwan, William, Solomon, Joshua
Publicado 2007

Type-I Interferons in Alzheimer's Disease and Other Tauopathies

por Sanford, Sophie A. I., McEwan, William A.
Publicado 2022

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

por Katsinelos, Taxiarchis, Tuck, Benjamin J., Mukadam, Aamir S., McEwan, William A.
Publicado 2019

Identification of cis-acting determinants mediating the unconventional secretion of tau

por Katsinelos, Taxiarchis, McEwan, William A., Jahn, Thomas R., Nickel, Walter
Publicado 2021

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

por Watkinson, Ruth E., McEwan, William A., Tam, Jerry C. H., Vaysburd, Marina, James, Leo C.
Publicado 2015

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

por Jacques, David A., McEwan, William A., Hilditch, Laura, Price, Amanda J., Towers, Greg J., James, Leo C.
Publicado 2016

A Method for the Acute and Rapid Degradation of Endogenous Proteins

por Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C., Schuh, Melina
Publicado 2017

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

por Brelstaff, Jack H., Mason, Matthew, Katsinelos, Taxiarchis, McEwan, William A., Ghetti, Bernardino, Tolkovsky, Aviva M., Spillantini, Maria Grazia
Publicado 2021

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

por Price, Amanda J., Jacques, David A., McEwan, William A., Fletcher, Adam J., Essig, Sebastian, Chin, Jason W., Halambage, Upul D., Aiken, Christopher, James, Leo C.
Publicado 2014

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

por Rodríguez-Silvestre, Pablo, Laub, Marco, Krawczyk, Patrycja A., Davies, Alexandra K., Schessner, Julia P., Parveen, Reejuana, Tuck, Benjamin J., McEwan, William A., Borner, Georg H.H., Kozik, Patrycja
Publicado 2023

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

por Mallery, Donna L, Márquez, Chantal L, McEwan, William A, Dickson, Claire F, Jacques, David A, Anandapadamanaban, Madhanagopal, Bichel, Katsiaryna, Towers, Gregory J, Saiardi, Adolfo, Böcking, Till, James, Leo C
Publicado 2018

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

por Nachman, Eliana, Wentink, Anne S., Madiona, Karine, Bousset, Luc, Katsinelos, Taxiarchis, Allinson, Kieren, Kampinga, Harm, McEwan, William A., Jahn, Thomas R., Melki, Ronald, Mogk, Axel, Bukau, Bernd, Nussbaum-Krammer, Carmen
Publicado 2020

Super-resolution imaging unveils the self-replication of tau aggregates upon seeding

por Dimou, Eleni, Katsinelos, Taxiarchis, Meisl, Georg, Tuck, Benjamin J., Keeling, Sophie, Smith, Annabel E., Hidari, Eric, Lam, Jeff Y.L., Burke, Melanie, Lövestam, Sofia, Ranasinghe, Rohan T., McEwan, William A., Klenerman, David
Publicado 2023

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

por Miller, Lauren V. C., Mukadam, Aamir S., Durrant, Claire S., Vaysburd, Marina J., Katsinelos, Taxiarchis, Tuck, Benjamin J., Sanford, Sophie, Sheppard, Olivia, Knox, Claire, Cheng, Shi, James, Leo C., Coleman, Michael P., McEwan, William A.
Publicado 2021

Cholesterol determines the cytosolic entry and seeded aggregation of tau

por Tuck, Benjamin J., Miller, Lauren V.C., Katsinelos, Taxiarchis, Smith, Annabel E., Wilson, Emma L., Keeling, Sophie, Cheng, Shi, Vaysburd, Marina J., Knox, Claire, Tredgett, Lucy, Metzakopian, Emmanouil, James, Leo C., McEwan, William A.
Publicado 2022

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models

por Mukadam, Aamir S, Miller, Lauren VC, Smith, Annabel E, Vaysburd, Marina, Sakya, Siri A, Sanford, Sophie, Keeling, Sophie, Tuck, Benjamin J, Katsinelos, Taxiarchis, Green, Chris, Skov, Lise, Kaalund, Sanne S, Foss, Stian, Mayes, Keith, O’Connell, Kevin, Wing, Mark, Knox, Claire, Banbury, Jessica, Avezov, Edward, Rowe, James B, Goedert, Michel, Andersen, Jan Terje, James, Leo C, McEwan, William A
Publicado 2023