Expansion of myeloid‐derived suppressor cells with aging in the bone marrow of mice through a NF‐κB‐dependent mechanism

por Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong‐Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2017

Attenuation of ataxia telangiectasia mutated signalling mitigates age‐associated intervertebral disc degeneration

por Han, Yingchao, Zhou, Chao‐Ming, Shen, Hongxing, Tan, Jun, Dong, Qing, Zhang, Lei, McGowan, Sara J., Zhao, Jing, Sowa, Gwendolyn A., Kang, James D., Niedernhofer, Laura J., Robbins, Paul D., Vo, Nam N.
Publicado 2020

Development of an IGF1R longevity variant mouse line using CRISPR/Cas9 genome editing

por Dou, Yan, Darvas, Martin, Sharma, Kavita, Mathieu, Julie, Morton, John, Tan, Heidi, Soto-Palma, Carolina, Angelini, Luise A, McGowan, Sara J, Niedernhofer, Laura J, Suh, Yousin, Robbins, Paul D, Barzilai, Nir, Ladiges, Warren C
Publicado 2020

Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/−) mice

por Huerta Guevara, Ana P., McGowan, Sara J., Kazantzis, Melissa, Stallons, Tania Rozgaja, Sano, Tokio, Mulder, Niels L., Jurdzinski, Angelika, van Dijk, Theo H., Eggen, Bart J.L., Jonker, Johan W., Niedernhofer, Laura J., Kruit, Janine K.
Publicado 2021

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

por Zhang, Lei, Zhao, Jing, Mu, Xiaodong, McGowan, Sara J., Angelini, Luise, O'Kelly, Ryan D., Yousefzadeh, Matthew J., Sakamoto, Ayumi, Aversa, Zaira, LeBrasseur, Nathan K., Suh, Yousin, Huard, Johnny, Kamenecka, Theodore M., Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2021

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

por Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.
Publicado 2020

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

por Zhao, Jing, Zhang, Lei, Mu, Xiaodong, Doebelin, Christelle, Nguyen, William, Wallace, Callen, Reay, Daniel P., McGowan, Sara J., Corbo, Lana, Clemens, Paula R., Wilson, Gabriela Mustata, Watkins, Simon C., Solt, Laura A., Cameron, Michael D., Huard, Johnny, Niedernhofer, Laura J., Kamenecka, Theodore M., Robbins, Paul D.
Publicado 2018

Identification of HSP90 inhibitors as a novel class of senolytics

por Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2017

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

por Zhao, Jing, Zhang, Lei, Lu, Aiping, Han, Yingchao, Colangelo, Debora, Bukata, Christina, Scibetta, Alex, Yousefzadeh, Matthew J., Li, Xuesen, Gurkar, Aditi U., McGowan, Sara J., Angelini, Luise, O’Kelly, Ryan, Li, Hongshuai, Corbo, Lana, Sano, Tokio, Nick, Heather, Pola, Enrico, Pilla, Smitha P.S., Ladiges, Warren C., Vo, Nam, Huard, Johnny, Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2020

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

por Dorronsoro, Akaitz, Santiago, Fernando E., Grassi, Diego, Zhang, Tianpeng, Lai, Ruenn Chai, McGowan, Sara J., Angelini, Luise, Lavasani, Mitra, Corbo, Lana, Lu, Aiping, Brooks, Robert W., Garcia‐Contreras, Marta, Stolz, Donna B., Amelio, Antonio, Boregowda, Siddaraju V., Fallahi, Mohammad, Reich, Adrian, Ricordi, Camillo, Phinney, Donald G., Huard, Johnny, Lim, Sai Kiang, Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2021

Fisetin is a senotherapeutic that extends health and lifespan

por Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.
Publicado 2018

Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy

por Henpita, Chathurika, Vyas, Rajesh, Healy, Chastity L., Kieu, Tra L., Gurkar, Aditi U., Yousefzadeh, Matthew J., Cui, Yuxiang, Lu, Aiping, Angelini, Luise A., O'Kelly, Ryan D., McGowan, Sara J., Chandrasekhar, Sanjay, Vanderpool, Rebecca R., Hennessy‐Wack, Danielle, Ross, Mark A., Bachman, Timothy N., McTiernan, Charles, Pillai, Smitha P. S., Ladiges, Warren, Lavasani, Mitra, Huard, Johnny, Beer‐Stolz, Donna, St. Croix, Claudette M., Watkins, Simon C., Robbins, Paul D., Mora, Ana L., Kelley, Eric E., Wang, Yinsheng, O'Connell, Timothy D., Niedernhofer, Laura J.
Publicado 2023

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

por Zhu, Yi, Tchkonia, Tamara, Pirtskhalava, Tamar, Gower, Adam C, Ding, Husheng, Giorgadze, Nino, Palmer, Allyson K, Ikeno, Yuji, Hubbard, Gene B, Lenburg, Marc, O’Hara, Steven P, LaRusso, Nicholas F, Miller, Jordan D, Roos, Carolyn M, Verzosa, Grace C, LeBrasseur, Nathan K, Wren, Jonathan D, Farr, Joshua N, Khosla, Sundeep, Stout, Michael B, McGowan, Sara J, Fuhrmann-Stroissnigg, Heike, Gurkar, Aditi U, Zhao, Jing, Colangelo, Debora, Dorronsoro, Akaitz, Ling, Yuan Yuan, Barghouthy, Amira S, Navarro, Diana C, Sano, Tokio, Robbins, Paul D, Niedernhofer, Laura J, Kirkland, James L
Publicado 2015

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

por Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M., Frantz, Marie-Céline, Bell-Temin, Harris, Pope-Varsalona, Hannah, Gurkar, Aditi U., Nasto, Luigi A., Robinson, Renã A.S., Fuhrmann-Stroissnigg, Heike, Czerwinska, Jolanta, McGowan, Sara J., Cantu-Medellin, Nadiezhda, Harris, Jamie B., Maniar, Salony, Ross, Mark A., Trussoni, Christy E., LaRusso, Nicholas F., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Tudek, Barbara, Vo, Nam V., Rigatti, Lora H., Opresko, Patricia L., Stolz, Donna B., Watkins, Simon C., Burd, Christin E., Croix, Claudette M. St., Siuzdak, Gary, Yates, Nathan A., Robbins, Paul D., Wang, Yinsheng, Wipf, Peter, Kelley, Eric E., Niedernhofer, Laura J.
Publicado 2018