Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging

por Stewart, Isabelle, Radtke, Daniel, Phillips, Bethan, McGowan, Simon J., Bannard, Oliver
Publicado 2018

Self-Organization and Regulation of Intrinsically Disordered Proteins with Folded N-Termini

por Simister, Philip C., Schaper, Fred, O'Reilly, Nicola, McGowan, Simon, Feller, Stephan M.
Publicado 2011

Quantitative Phosphoproteome Analysis Unveils LAT as a Modulator of CD3ζ and ZAP-70 Tyrosine Phosphorylation

por Salek, Mogjiborahman, McGowan, Simon, Trudgian, David C., Dushek, Omer, de Wet, Ben, Efstathiou, Georgios, Acuto, Oreste
Publicado 2013

Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

por Bannard, Oliver, McGowan, Simon J., Ersching, Jonatan, Ishido, Satoshi, Victora, Gabriel D., Shin, Jeoung-Sook, Cyster, Jason G.
Publicado 2016

Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints

por Schwessinger, Ron, Suciu, Maria C., McGowan, Simon J., Telenius, Jelena, Taylor, Stephen, Higgs, Doug R., Hughes, Jim R.
Publicado 2017

The small FNR regulon of Neisseria gonorrhoeae: comparison with the larger Escherichia coli FNR regulon and interaction with the NarQ-NarP regulon

por Whitehead, Rebekah N, Overton, Tim W, Snyder, Lori AS, McGowan, Simon J, Smith, Harry, Cole, Jeff A, Saunders, Nigel J
Publicado 2007

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

por Ledaki, Ioanna, McIntyre, Alan, Wigfield, Simon, Buffa, Francesca, McGowan, Simon, Baban, Dilair, Li, Ji-liang, Harris, Adrian L.
Publicado 2015

CSynth: an interactive modelling and visualization tool for 3D chromatin structure

por Todd, Stephen, Todd, Peter, McGowan, Simon J, Hughes, James R, Kakui, Yasutaka, Leymarie, Frederic Fol, Latham, William, Taylor, Stephen
Publicado 2020

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

por Davies, James O.J., Telenius, Jelena M., McGowan, Simon, Roberts, Nigel A., Taylor, Stephen, Higgs, Douglas R., Hughes, Jim R.
Publicado 2015

Majeed syndrome: description of a novel mutation and therapeutic response to bisphosphonates and IL-1 blockade with anakinra

por Roy, Noémi B A, Zaal, Ahmad I, Hall, Georgina, Wilkinson, Nick, Proven, Melanie, McGowan, Simon, Hipkiss, Ria, Buckle, Veronica, Kavirayani, Akhila, Babbs, Christian
Publicado 2020

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component

por Brockmeyer, Claudia, Paster, Wolfgang, Pepper, David, Tan, Choon P., Trudgian, David C., McGowan, Simon, Fu, Guo, Gascoigne, Nicholas R. J., Acuto, Oreste, Salek, Mogjiborahman
Publicado 2011

Disruption of TWIST1 translation by 5′ UTR variants in Saethre‐Chotzen syndrome

por Zhou, Yan, Koelling, Nils, Fenwick, Aimée L., McGowan, Simon J., Calpena, Eduardo, Wall, Steven A., Smithson, Sarah F., Wilkie, Andrew O.M., Twigg, Stephen R.F.
Publicado 2018

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

por Goriely, Anne, Hansen, Ruth M. S., Taylor, Indira B., Olesen, Inge A., Jacobsen, Grete Krag, McGowan, Simon J., Pfeifer, Susanne P., McVean, Gilean A. T., Meyts, Ewa Rajpert-De, Wilkie, Andrew O.M.
Publicado 2009

Understanding functional miRNA–target interactions in vivo by site-specific genome engineering

por Bassett, Andrew R., Azzam, Ghows, Wheatley, Lucy, Tibbit, Charlotte, Rajakumar, Timothy, McGowan, Simon, Stanger, Nathan, Ewels, Philip Andrew, Taylor, Stephen, Ponting, Chris P., Liu, Ji-Long, Sauka-Spengler, Tatjana, Fulga, Tudor A.
Publicado 2014

Dynamic Analysis of Gene Expression and Genome-wide Transcription Factor Binding during Lineage Specification of Multipotent Progenitors

por May, Gillian, Soneji, Shamit, Tipping, Alex J., Teles, Jose, McGowan, Simon J., Wu, Mengchu, Guo, Yanping, Fugazza, Cristina, Brown, John, Karlsson, Göran, Pina, Cristina, Olariu, Victor, Taylor, Stephen, Tenen, Daniel G., Peterson, Carsten, Enver, Tariq
Publicado 2013

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing

por Rodriguez-Meira, Alba, Buck, Gemma, Clark, Sally-Ann, Povinelli, Benjamin J., Alcolea, Veronica, Louka, Eleni, McGowan, Simon, Hamblin, Angela, Sousos, Nikolaos, Barkas, Nikolaos, Giustacchini, Alice, Psaila, Bethan, Jacobsen, Sten Eirik W., Thongjuea, Supat, Mead, Adam J.
Publicado 2019

De novo and rare inherited mutations implicate the transcriptional coregulator TCF20/SPBP in autism spectrum disorder

por Babbs, Christian, Lloyd, Deborah, Pagnamenta, Alistair T, Twigg, Stephen R F, Green, Joanne, McGowan, Simon J, Mirza, Ghazala, Naples, Rebecca, Sharma, Vikram P, Volpi, Emanuela V, Buckle, Veronica J, Wall, Steven A, Knight, Samantha J L, Parr, Jeremy R, Wilkie, Andrew O M
Publicado 2014

Congenital myasthenic syndromes due to mutations in ALG2 and ALG14

por Cossins, Judith, Belaya, Katsiaryna, Hicks, Debbie, Salih, Mustafa A., Finlayson, Sarah, Carboni, Nicola, Liu, Wei Wei, Maxwell, Susan, Zoltowska, Katarzyna, Farsani, Golara Torabi, Laval, Steven, Seidhamed, Mohammed Zain, Donnelly, Peter, Bentley, David, McGowan, Simon J., Müller, Juliane, Palace, Jacqueline, Lochmüller, Hanns, Beeson, David
Publicado 2013

Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders

por Calpena, Eduardo, Wurmser, Maud, McGowan, Simon J, Atique, Rodrigo, Bertola, Débora R, Cunningham, Michael L, Gustafson, Jonas A, Johnson, David, Morton, Jenny E V, Passos-Bueno, Maria Rita, Timberlake, Andrew T, Lifton, Richard P, Wall, Steven A, Twigg, Stephen R F, Maire, Pascal, Wilkie, Andrew O M
Publicado 2022

Mutations in GMPPB cause congenital myasthenic syndrome and bridge myasthenic disorders with dystroglycanopathies

por Belaya, Katsiaryna, Rodríguez Cruz, Pedro M., Liu, Wei Wei, Maxwell, Susan, McGowan, Simon, Farrugia, Maria E., Petty, Richard, Walls, Timothy J., Sedghi, Maryam, Basiri, Keivan, Yue, Wyatt W., Sarkozy, Anna, Bertoli, Marta, Pitt, Matthew, Kennett, Robin, Schaefer, Andrew, Bushby, Kate, Parton, Matt, Lochmüller, Hanns, Palace, Jacqueline, Muntoni, Francesco, Beeson, David
Publicado 2015