Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis

por Selyunin, Andrey S, Hutchens, Steven, McHardy, Stanton F, Mukhopadhyay, Somshuvra
Publicado 2019

Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins

por Selyunin, Andrey S., Nieves-Merced, Karinel, Li, Danyang, McHardy, Stanton F., Mukhopadhyay, Somshuvra
Publicado 2021

Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments

por Toth, Katalin, Alwan, Sevan, Khan, Susan, McHardy, Stanton F., LoVerde, Philip T., Cameron, Michael D.
Publicado 2023

Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis

por Alwan, Sevan N., Taylor, Alexander B., Rhodes, Jayce, Tidwell, Michael, McHardy, Stanton F., LoVerde, Philip T.
Publicado 2023

Rational approach to drug discovery for human schistosomiasis

por LoVerde, Philip T., Alwan, Sevan N., Taylor, Alexander B., Rhodes, Jayce, Chevalier, Frédéric D., Anderson, Timothy JC., McHardy, Stanton F.
Publicado 2021

Corrigendum to “Rational approach to drug discovery for human schistosomiasis” [Int. J. Parasitol. Drugs Drug Resist. 16 (2021) 140–147]

por LoVerde, Philip T., Alwan, Sevan N., Taylor, Alexander B., Rhodes, Jayce, Chevalier, Frédéric D., Anderson, Timothy Jc, McHardy, Stanton F.
Publicado 2022

A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

por Pierce, Christopher G, Chaturvedi, Ashok K, Lazzell, Anna L, Powell, Alexander T, Saville, Stephen P, McHardy, Stanton F, Lopez-Ribot, Jose L
Publicado 2015

Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation

por Romo, Jesus A., Pierce, Christopher G., Chaturvedi, Ashok K., Lazzell, Anna L., McHardy, Stanton F., Saville, Stephen P., Lopez-Ribot, Jose L.
Publicado 2017

Inhibition of Ca(2+) entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation

por Sun, Yuyang, Zboril, Emily K., De La Chapa, Jorge J., Chai, Xiufang, Da Conceicao, Viviane Nascimento, Valdez, Matthew C., McHardy, Stanton F., Gonzales, Cara B., Singh, Brij B.
Publicado 2022

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

por Rugel, Anastasia R., Guzman, Meghan A., Taylor, Alexander B., Chevalier, Frédéric D., Tarpley, Reid S., McHardy, Stanton F., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J.C., Hart, P. John, LoVerde, Philip T.
Publicado 2020

Schistosome Sulfotransferases: Mode of Action, Expression and Localization

por Guzman, Meghan A., Rugel, Anastasia, Alwan, Sevan N., Tarpley, Reid, Taylor, Alexander B., Chevalier, Frédéric D., Wendt, George R., Collins, James J., Anderson, Timothy J. C., McHardy, Stanton F., LoVerde, Philip T.
Publicado 2022

An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans

por Guzman, Meghan A., Rugel, Anastasia R., Tarpley, Reid S., Alwan, Sevan N., Chevalier, Frédéric D., Kovalskyy, Dmytro P., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J. C., Taylor, Alexander B., McHardy, Stanton F., LoVerde, Philip T.
Publicado 2020