Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration

por McHugh, Brian J., Murdoch, Amanda, Haslett, Christopher, Sethi, Tariq
Publicado 2012

Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?

por Dockrell, David H., Russell, Clark D., McHugh, Brian, Fraser, Rupsha
Publicado 2022

A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages

por Rodriguez-Rios, Maria, McHugh, Brian J., Liang, Zhengqi, Megia-Fernandez, Alicia, Lilienkampf, Annamaria, Dockrell, David, Bradley, Mark
Publicado 2023

Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration

por McHugh, Brian, Krause, Sue A., Yu, Bin, Deans, Anne-Marie, Heasman, Sarah, McLaughlin, Paul, Heck, Margarete M.S.
Publicado 2004

A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro

por Shelley, Jennifer R., McHugh, Brian J., Wills, Jimi, Dorin, Julia R., Weller, Richard, Clarke, David J., Davidson, Donald J.
Publicado 2023

Human Cathelicidin Production by the Cervix

por Frew, Lorraine, Makieva, Sofia, McKinlay, Andrew T. M., McHugh, Brian J., Doust, Ann, Norman, Jane E., Davidson, Donald J., Stock, Sarah J.
Publicado 2014

IL-1β–Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human β-Defensin 2

por Wang, Bingjie, McHugh, Brian J., Qureshi, Ayub, Campopiano, Dominic J., Clarke, David J., Fitzgerald, J. Ross, Dorin, Julia R., Weller, Richard, Davidson, Donald J.
Publicado 2017

Inhibition of Cyclin-Dependent Kinase 9 Downregulates Cytokine Production Without Detrimentally Affecting Human Monocyte-Derived Macrophage Viability

por McHugh, Brian J., Stephen, Jillian, Robb, Calum T., Fox, Sarah, Kipari, Tiina, Cartwright, Jennifer A., Haslett, Christopher, Duffin, Rodger, Lucas, Christopher D., Rossi, Adriano G.
Publicado 2022

The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus

por Currie, Silke M., Findlay, Emily Gwyer, McHugh, Brian J., Mackellar, Annie, Man, Tian, Macmillan, Derek, Wang, Hongwei, Fitch, Paul M., Schwarze, Jürgen, Davidson, Donald J.
Publicado 2013

Differential response to bacteria, and TOLLIP expression, in the human respiratory tract

por Moncayo-Nieto, Olga Lucia, Wilkinson, Thomas S, Brittan, Mairi, McHugh, Brian J, Jones, Richard O, Conway Morris, Andrew, Walker, William S, Davidson, Donald J, Simpson, A John
Publicado 2014

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

por Beaumont, Paula E., McHugh, Brian, Gwyer Findlay, Emily, Mackellar, Annie, Mackenzie, Karen J., Gallo, Richard L., Govan, John R. W., Simpson, A. John, Davidson, Donald J.
Publicado 2014

The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation

por Smith, Katie J., Minns, Danielle, McHugh, Brian J., Holloway, Rebecca K., O’Connor, Richard, Williams, Anna, Melrose, Lauren, McPherson, Rhoanne, Miron, Veronique E., Davidson, Donald J., Gwyer Findlay, Emily
Publicado 2022

Cathelicidins and the Onset of Labour

por Boeckel, Sara R. van, Hrabalkova, Lenka, Baker, Tina L., MacPherson, Heather, Frew, Lorraine, Boyle, Ashley K., McHugh, Brian J., Wilson, Kirsten, Norman, Jane E., Dorin, Julia R., Davidson, Donald J., Stock, Sarah J.
Publicado 2019

Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation

por Humphries, Duncan C., Mills, Ross, Boz, Cecilia, McHugh, Brian J., Hirani, Nikhil, Rossi, Adriano G., Pedersen, Anders, Schambye, Hans T., Slack, Robert J., Leffler, Hakon, Nilsson, Ulf J., Wang, Wei, Sethi, Tariq, Mackinnon, Alison C.
Publicado 2022

Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

por McHugh, Brian J., Wang, Rongling, Li, Hsin-Ni, Beaumont, Paula E., Kells, Rebekah, Stevens, Holly, Young, Lisa, Rossi, Adriano G., Gray, Robert D., Dorin, Julia R., Gwyer Findlay, Emily L., Brough, David, Davidson, Donald J.
Publicado 2019

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy

por Findlay, Emily Gwyer, Currie, Andrew J., Zhang, Ailiang, Ovciarikova, Jana, Young, Lisa, Stevens, Holly, McHugh, Brian J., Canel, Marta, Gray, Mohini, Milling, Simon W.F., Campbell, John D.M., Savill, John, Serrels, Alan, Davidson, Donald J.
Publicado 2019

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

por Ryan, Eilise M., Sadiku, Pranvera, Coelho, Patricia, Watts, Emily R., Zhang, Ailiang, Howden, Andrew J. M., Sanchez-Garcia, Manuel A., Bewley, Martin, Cole, Joby, McHugh, Brian J., Vermaelen, Wesley, Ghesquiere, Bart, Carmeliet, Peter, Rodriguez Blanco, Giovanny, Von Kriegsheim, Alex, Sanchez, Yolanda, Rumsey, William, Callahan, James F., Cooper, George, Parkinson, Nicholas, Baillie, Kenneth, Cantrell, Doreen A., McCafferty, John, Choudhury, Gourab, Singh, Dave, Dockrell, David H., Whyte, Moira K. B., Walmsley, Sarah R.
Publicado 2023