AQ4N: a new approach to hypoxia-activated cancer chemotherapy

por Patterson, L H, McKeown, S R
Publicado 2000

Targeting DNA topoisomerase IIα (TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs (uHAPs)

por Smith, Paul J., McKeown, Stephanie R., Patterson, Laurence H.
Publicado 2022

The effect of recombinant human erythropoietin treatment on tumour radiosensitivity and cancer-associated anaemia in the mouse.

por Joiner, B., Hirst, V. K., McKeown, S. R., McAleer, J. J., Hirst, D. G.
Publicado 1993

Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells

por Dunne, A L, Price, M E, Mothersill, C, McKeown, S R, Robson, T, Hirst, D G
Publicado 2003

Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance

por Browne, G, Nesbitt, H, Ming, L, Stein, G S, Lian, J B, McKeown, S R, Worthington, J
Publicado 2012

Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition

por Byrne, N M, Nesbitt, H, Ming, L, McKeown, S R, Worthington, J, McKenna, D J
Publicado 2016

AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo.

por McKeown, S. R., Hejmadi, M. V., McIntyre, I. A., McAleer, J. J., Patterson, L. H.
Publicado 1995

Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation

por McKeown, S R, Robson, T, Price, M E, Ho, E T S, Hirst, D G, McKelvey-Martin, V J
Publicado 2003

Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

por Patterson, L H, McKeown, S R, Ruparelia, K, Double, J A, Bibby, M C, Cole, S, Stratford, I J
Publicado 2000

DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells.

por Hejmadi, M. V., McKeown, S. R., Friery, O. P., McIntyre, I. A., Patterson, L. H., Hirst, D. G.
Publicado 1996

Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation

por McKenna, Declan J., Doherty, Bernadette A., Downes, C. Stephen, McKeown, Stephanie R., McKelvey-Martin, Valerie J.
Publicado 2012

Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles

por Ta, Aaron C, Huang, Lin-Chien, McKeown, Caroline R, Bestman, Jennifer E, Van Keuren-Jensen, Kendall, Cline, Hollis T
Publicado 2021

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N

por Gallagher, R, Hughes, C M, Murray, M M, Friery, O P, Patterson, L H, Hirst, D G, McKeown, S R
Publicado 2001

The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N

por Gallagher, R, Hughes, C M, Murray, M M, Friery, O P, Patterson, L H, Hirst, D G, McKeown, S R
Publicado 2002

Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology

por Gokhin, David S., Lewis, Raymond A., McKeown, Caroline R., Nowak, Roberta B., Kim, Nancy E., Littlefield, Ryan S., Lieber, Richard L., Fowler, Velia M.
Publicado 2010

Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine

por Friery, O P, Gallagher, R, Murray, M M, Hughes, C M, Galligan, E S, McIntyre, I A, Patterson, L H, Hirst, D G, McKeown, S R
Publicado 2000

Dexamethasone potentiates the antiangiogenic activity of docetaxel in castration-resistant prostate cancer

por Wilson, C, Scullin, P, Worthington, J, Seaton, A, Maxwell, P, O'Rourke, D, Johnston, P G, McKeown, S R, Wilson, R H, O'Sullivan, J M, Waugh, D J J
Publicado 2008

Small-Molecule Inhibition of BRDT for Male Contraception

por Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.
Publicado 2012

Improving FRET dynamic range with bright green and red fluorescent proteins

por Lam, Amy, St-Pierre, François, Gong, Yiyang, Marshall, Jesse D., Cranfill, Paula J., Baird, Michelle A., McKeown, Michael R., Wiedenmann, Jörg, Davidson, Michael W., Schnitzer, Mark J., Tsien, Roger Y., Lin, Michael Z.
Publicado 2012

Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors

por McKeown, Michael R, Shaw, Daniel L, Fu, Harry, Liu, Shuai, Xu, Xiang, Marineau, Jason J, Huang, Yibo, Zhang, Xiaofeng, Buckley, Dennis L, Kadam, Asha, Zhang, Zijuan, Blacklow, Stephen C, Qi, Jun, Zhang, Wei, Bradner, James E
Publicado 2014