Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

por Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin, Daniel, Cohen, Charles J., Chen, Jun
Publicado 2018

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

por Parker, Christopher G., Kuttruff, Christian A., Galmozzi, Andrea, Jørgensen, Lars, Yeh, Chien-Hung, Hermanson, Daniel J., Wang, Yujia, Artola, Marta, McKerrall, Steven J., Josyln, Christopher M., Nørremark, Bjarne, Dünstl, Georg, Felding, Jakob, Saez, Enrique, Baran, Phil S., Cravatt, Benjamin F.
Publicado 2017

Cryo-EM reveals an unprecedented binding site for Na(V)1.7 inhibitors enabling rational design of potent hybrid inhibitors

por Kschonsak, Marc, Jao, Christine C, Arthur, Christopher P, Rohou, Alexis L, Bergeron, Philippe, Ortwine, Daniel F, McKerrall, Steven J, Hackos, David H, Deng, Lunbin, Chen, Jun, Li, Tianbo, Dragovich, Peter S, Volgraf, Matthew, Wright, Matthew R, Payandeh, Jian, Ciferri, Claudio, Tellis, John C
Publicado 2023