Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction

por Sadee, Wolfgang, McKew, John C.
Publicado 2022

Development of a Predictive Enrichment Marker for the Oral GH Secretagogue LUM-201 in Pediatric Growth Hormone Deficiency

por Bright, George M, Do, Minh-Ha T, McKew, John C, Blum, Werner F, Thorner, Michael O
Publicado 2021

Corroboration of Height Velocity Prediction Markers for rhGH With an Oral GH Secretagogue Treatment in Children With GHD

por Blum, Werner F, Bright, George M, Do, Minh-Ha T, McKew, John C, Chen, Haiying, Thorner, Michael O
Publicado 2021

Plasma and Tissue Concentrations of α-Tocopherol and δ-Tocopherol Following High Dose Dietary Supplementation in Mice

por Baxter, Laura L., Marugan, Juan J., Xiao, Jingbo, Incao, Art, McKew, John C., Zheng, Wei, Pavan, William J.
Publicado 2012

High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1

por Wang, Mengqiao, Xu, Miao, Long, Yan, Fargue, Sonia, Southall, Noel, Hu, Xin, McKew, John C., Danpure, Christopher J., Zheng, Wei
Publicado 2016

An open source pharma roadmap

por Balasegaram, Manica, Kolb, Peter, McKew, John, Menon, Jaykumar, Olliaro, Piero, Sablinski, Tomasz, Thomas, Zakir, Todd, Matthew H., Torreele, Els, Wilbanks, John
Publicado 2017

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

por Thorne, Natasha, Malik, Nasir, Shah, Sonia, Zhao, Jean, Class, Bradley, Aguisanda, Francis, Southall, Noel, Xia, Menghang, McKew, John C., Rao, Mahendra, Zheng, Wei
Publicado 2016

Chemical signatures and new drug targets for gametocytocidal drug development

por Sun, Wei, Tanaka, Takeshi Q., Magle, Crystal T., Huang, Wenwei, Southall, Noel, Huang, Ruili, Dehdashti, Seameen J., McKew, John C., Williamson, Kim C., Zheng, Wei
Publicado 2014

Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

por Sun, Wei, Park, Yoon-Dong, Sugui, Janyce A., Fothergill, Annette, Southall, Noel, Shinn, Paul, McKew, John C., Kwon-Chung, Kyung J., Zheng, Wei, Williamson, Peter R.
Publicado 2013

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

por Sun, Wei, Park, Yoon-Dong, Sugui, Janyce A., Fothergill, Annette, Southall, Noel, Shinn, Paul, McKew, John C., Kwon-Chung, Kyung J., Zheng, Wei, Williamson, Peter R.
Publicado 2013

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

por Sun, Wei, Park, Yoon-Dong, Sugui, Janyce A., Fothergill, Annette, Southall, Noel, Shinn, Paul, McKew, John C., Kwon-Chung, Kyung J., Zheng, Wei, Williamson, Peter R.
Publicado 2013

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

por Kouznetsova, Jennifer, Sun, Wei, Martínez-Romero, Carles, Tawa, Gregory, Shinn, Paul, Chen, Catherine Z, Schimmer, Aaron, Sanderson, Philip, McKew, John C, Zheng, Wei, García-Sastre, Adolfo
Publicado 2014

Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

por Padilha, Elias C., Wang, Jianyao, Kerns, Ed, Lee, Arthur, Huang, Wenwei, Jiang, Jian-kang, McKew, John, Mutlib, Abdul, Peccinini, Rosangela G., Yu, Paul B., Sanderson, Philip, Xu, Xin
Publicado 2019

OR21-03 Dose Responsiveness Of LUM-201 As Measured By Acute GH Response And IGF-1 And Annualized Height Velocity (AHV) Measured At 6 Months In The Interim Analysis Of The OraGrowtH...

por Cassorla, Fernando, Román, Rossana, Johnson, Michael Linn, Avila, Alejandra, Iñiguez, Germán, Baier, Ingrid, Said, Daniela, Bruchey, Aleksandra, Smith, Christopher, Brincks, Erik L, McKew, John C, Karpf, David B, Thorner, Michael O
Publicado 2023

Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency

por Cacciante, Francesco, Gennaro, Mariangela, Sagona, Giulia, Mazziotti, Raffaele, Lupori, Leonardo, Cerri, Elisa, Putignano, Elena, Butt, Mark, Do, Minh-Ha T., McKew, John C., Alessandrì, Maria Grazia, Battini, Roberta, Cioni, Giovanni, Pizzorusso, Tommaso, Baroncelli, Laura
Publicado 2020

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

por Ong, Christy C, Gierke, Sarah, Pitt, Cameron, Sagolla, Meredith, Cheng, Christine K, Zhou, Wei, Jubb, Adrian M, Strickland, Laura, Schmidt, Maike, Duron, Sergio G, Campbell, David A, Zheng, Wei, Dehdashti, Seameen, Shen, Min, Yang, Nora, Behnke, Mark L, Huang, Wenwei, McKew, John C, Chernoff, Jonathan, Forrest, William F, Haverty, Peter M, Chin, Suet-Feung, Rakha, Emad A, Green, Andrew R, Ellis, Ian O, Caldas, Carlos, O’Brien, Thomas, Friedman, Lori S, Koeppen, Hartmut, Rudolph, Joachim, Hoeflich, Klaus P
Publicado 2015

OR21-06 Growth Response Of Oral LUM-201 In OraGrowtH210 And OraGrowtH212 Trials In Idiopathic Pediatric Growth Hormone Deficiency (iPGHD): Combined Analysis Interim Analysis Data

por Tansey, Michael J, Bowden, Sasigarn Arunchaiya, Dauber, Andrew Nahum, Wikiera, Beata, Pyrzak, Beata, Bossowski, Artur T, Petriczko, Elzbieta, Stawerska, Renata, Moszczynska, Elzbieta, Cassorla, Fernando, Feldt, Matthew M, Lunsford, Alison J, Gottschalk, Michael Everett, Marin, Monica, Nayak, Sunil N, Bhuvana, Sunil, Repaske, David Roy, Soyka, Leslie Ann, Fuqua, John S, Escobar, Oscar, Bowlby, Deborah A, Fechner, Patricia Y, Wiltshire, Esko, Harris, Mark, Wintergerst, Kupper A, Lafferty, Antony Richard A, Miller, Bradley S, Simm, Peter, Bruchey, Aleksandra, Smith, Christopher, Karpf, David B, McKew, John C, Thorner, Michael O
Publicado 2023