Structure and function of the cytochrome P450 peroxygenase enzymes

por Munro, Andrew W., McLean, Kirsty J., Grant, Job L., Makris, Thomas M.
Publicado 2018

A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism

por Thistlethwaite, Sian, Jeffreys, Laura N., Girvan, Hazel M., McLean, Kirsty J., Munro, Andrew W.
Publicado 2021

Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126

por Hudson, Sean A, Mashalidis, Ellene H, Bender, Andreas, McLean, Kirsty J, Munro, Andrew W, Abell, Chris
Publicado 2014

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121

por Hudson, Sean A., Surade, Sachin, Coyne, Anthony G., McLean, Kirsty J., Leys, David, Munro, Andrew W., Abell, Chris
Publicado 2013

Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment

por Parsons, Joshua B., Lawrence, Andrew D., McLean, Kirsty J., Munro, Andrew W., Rigby, Stephen E. J., Warren, Martin J.
Publicado 2010

Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin

por Ashworth, Mark A., Bombino, Elvira, de Jong, René M., Wijma, Hein J., Janssen, Dick B., McLean, Kirsty J., Munro, Andrew W.
Publicado 2022

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

por Girvan, Hazel M., Poddar, Harshwardhan, McLean, Kirsty J., Nelson, David R., Hollywood, Katherine A., Levy, Colin W., Leys, David, Munro, Andrew W.
Publicado 2018

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

por Kavanagh, Madeline E., Gray, Janine L., Gilbert, Sophie H., Coyne, Anthony G., McLean, Kirsty J., Davis, Holly J., Munro, Andrew W., Abell, Chris
Publicado 2016

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

por Jeffreys, Laura N., Poddar, Harshwardhan, Golovanova, Marina, Levy, Colin W., Girvan, Hazel M., McLean, Kirsty J., Voice, Michael W., Leys, David, Munro, Andrew W.
Publicado 2019

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

por Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Munro, Andrew W., Simons, Claire
Publicado 2019

Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila

por Baker, George J., Girvan, Hazel M., Matthews, Sarah, McLean, Kirsty J., Golovanova, Marina, Waltham, Timothy N., Rigby, Stephen E. J., Nelson, David R., Blankley, Richard T., Munro, Andrew W.
Publicado 2017

Bacillus megaterium Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species

por Collins, Hannah F., Biedendieck, Rebekka, Leech, Helen K., Gray, Michael, Escalante-Semerena, Jorge C., McLean, Kirsty J., Munro, Andrew W., Rigby, Stephen E. J., Warren, Martin J., Lawrence, Andrew D.
Publicado 2013

Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s Is Isoform Dependent

por Conner, Kip P., Schimpf, Alina M., Cruce, Alex A., McLean, Kirsty J., Munro, Andrew W., Frank, Daniel J., Krzyaniak, Matthew D., Ortiz de Montellano, Paul, Bowman, Michael K., Atkins, William M.
Publicado 2014

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)

por Matthews, Sarah, Belcher, James D., Tee, Kang Lan, Girvan, Hazel M., McLean, Kirsty J., Rigby, Stephen E. J., Levy, Colin W., Leys, David, Parker, David A., Blankley, Richard T., Munro, Andrew W.
Publicado 2017

Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

por Chenge, Jude, Kavanagh, Madeline E., Driscoll, Max D., McLean, Kirsty J., Young, Douglas B., Cortes, Teresa, Matak-Vinkovic, Dijana, Levy, Colin W., Rigby, Stephen E. J., Leys, David, Abell, Chris, Munro, Andrew W.
Publicado 2016

The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynth...

por Palmer, David J, Schroeder, Susanne, Lawrence, Andrew D, Deery, Evelyne, Lobo, Susana A, Saraiva, Ligia M, McLean, Kirsty J, Munro, Andrew W, Ferguson, Stuart J, Pickersgill, Richard W, Brown, David G, Warren, Martin J
Publicado 2014

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

por Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Smith, Darren, Evans, Jack W.D., Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Levy, Colin W., Munro, Andrew W., Simons, Claire
Publicado 2019

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

por Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Publicado 2016

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

por Taban, Ismail M., Elshihawy, Hosam E. A. E., Torun, Beyza, Zucchini, Benedetta, Williamson, Clare J., Altuwairigi, Dania, Ngu, Adeline S. T., McLean, Kirsty J., Levy, Colin W., Sood, Sakshi, Marino, Leonardo B., Munro, Andrew W., de Carvalho, Luiz Pedro S., Simons, Claire
Publicado 2017

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

por Chenge, Jude T., Duyet, Le Van, Swami, Shalini, McLean, Kirsty J., Kavanagh, Madeline E., Coyne, Anthony G., Rigby, Stephen E. J., Cheesman, Myles R., Girvan, Hazel M., Levy, Colin W., Rupp, Bernd, von Kries, Jens P., Abell, Chris, Leys, David, Munro, Andrew W.
Publicado 2017