The allergy gene: how a mutation in a skin protein revealed a link between eczema and asthma

por McLean, W. H. Irwin
Publicado 2011

One remarkable molecule: Filaggrin

por Brown, Sara J., McLean, W. H. Irwin
Publicado 2011

Keratin 6b variant p.Gly499Ser reported in delayed‐onset pachyonychia congenita is a non‐pathogenic polymorphism

por Smith, Frances J. D., McLean, W. H. Irwin
Publicado 2017

Identification of a Novel Family of Laminin N-terminal Alternate Splice Isoforms: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION

por Hamill, Kevin J., Langbein, Lutz, Jones, Jonathan C. R., McLean, W. H. Irwin
Publicado 2009

Obtaining DNA in the mail from a national sample of children with a chronic non-fatal illness

por Margolis, David J., Papadopoulos, Maryte, Apter, Andrea, McLean, W. H. Irwin, Mitra, Nandita, Rebbeck, Tim
Publicado 2011

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

por McElroy, Stuart P., Nomura, Toshifumi, Torrie, Leah S., Warbrick, Emma, Gartner, Ulrike, Wood, Gavin, McLean, W. H. Irwin
Publicado 2013

Development of a Corneal Bioluminescence Mouse for Real-Time In Vivo Evaluation of Gene Therapies

por Fu, Dun Jack, Allen, Edwin H. A., Hickerson, Robyn P., Leslie Pedrioli, Deena M., McLean, W. H. Irwin
Publicado 2020

Chromosome 11q13.5 variant associated with childhood eczema: An effect supplementary to filaggrin mutations

por O'Regan, Gráinne M., Campbell, Linda E., Cordell, Heather J., Irvine, Alan D., McLean, W.H. Irwin, Brown, Sara J.
Publicado 2010

Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

por Kelleher, Maeve, Dunn-Galvin, Audrey, Hourihane, Jonathan O'B., Murray, Deirdre, Campbell, Linda E., McLean, W.H. Irwin, Irvine, Alan D.
Publicado 2015

In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

por Hegde, Vikas, Hickerson, Robyn P., Nainamalai, Sitheswaran, Campbell, Paul A., Smith, Frances J.D., McLean, W.H. Irwin, Leslie Pedrioli, Deena M.
Publicado 2014

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

por Brown, Sara J, Kroboth, Karin, Sandilands, Aileen, Campbell, Linda E, Pohler, Elizabeth, Kezic, Sanja, Cordell, Heather J, McLean, W H Irwin, Irvine, Alan D
Publicado 2012

Carrier Status for the Common R501X and 2282del4 Filaggrin Mutations Is Not Associated with Hearing Phenotypes in 5377 Children from the ALSPAC Cohort

por Rodriguez, Santiago, Hall, Amanda J., Granell, Raquel, McLean, W. H. Irwin, Irvine, Alan D., Palmer, Colin N. A., Smith, George Davey, Henderson, John, Day, Ian N. M.
Publicado 2009

Improved Annotation of 3′ Untranslated Regions and Complex Loci by Combination of Strand-Specific Direct RNA Sequencing, RNA-Seq and ESTs

por Schurch, Nicholas J., Cole, Christian, Sherstnev, Alexander, Song, Junfang, Duc, Céline, Storey, Kate G., McLean, W. H. Irwin, Brown, Sara J., Simpson, Gordon G., Barton, Geoffrey J.
Publicado 2014

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

por Simpson, Eric L., Chalmers, Joanne R., Hanifin, Jon M., Thomas, Kim S., Cork, Michael J., McLean, W.H. Irwin, Brown, Sara J., Chen, Zunqiu, Chen, Yiyi, Williams, Hywel C.
Publicado 2014

Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study

por Visser, Maaike J, Verberk, Maarten M, Campbell, Linda E, McLean, W H Irwin, Calkoen, Florentine, Bakker, Jan G, van Dijk, Frank J H, Bos, Jan D, Kezic, Sanja
Publicado 2014

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

por Forbes, Deborah, Johnston, Leona, Gardner, June, MacCallum, Stephanie F., Campbell, Linda E., Dinkova-Kostova, Albena T., McLean, W.H. Irwin, Ibbotson, Sally H., Dawe, Robert S., Brown, Sara J.
Publicado 2016

Expanding the Phenotypic Spectrum of Olmsted Syndrome

por Wilson, Neil J, Cole, Christian, Milstone, Leonard M, Kiszewski, Ana E, Hansen, C David, O'Toole, Edel A, Schwartz, Mary E, McLean, W H Irwin, Smith, Frances J D
Publicado 2015

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

por Bell, Mark, Foley, David, Naylor, Claire, Robinson, Colin, Riley, Jennifer, Epemolu, Ola, Scullion, Paul, Shishikura, Yoko, Katz, Elad, McLean, W.H. Irwin, Wyatt, Paul, Read, Kevin D., Woodland, Andrew
Publicado 2018

Report of the tenth annual International Pachyonychia Congenita Consortium meeting

por van Steensel, Maurice A.M., Coulombe, Pierre A., Kaspar, Roger L., Milstone, Leonard M., McLean, W.H. Irwin, Roop, Dennis R., Smith, Frances J.D., Sprecher, Eli, Schwartz, Mary E.
Publicado 2014

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year...

por Kennedy, Elizabeth A., Connolly, Jennifer, Hourihane, Jonathan O'B., Fallon, Padraic G., McLean, W.H. Irwin, Murray, Deirdre, Jo, Jay-Hyun, Segre, Julia A., Kong, Heidi H., Irvine, Alan D.
Publicado 2017