Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes

por Vishwakarma, Raghvendra, McManus, Kirk J.
Publicado 2020

Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells

por Guppy, Brent J., McManus, Kirk J.
Publicado 2015

A Novel Multiplexed, Image-Based Approach to Detect Phenotypes That Underlie Chromosome Instability in Human Cells

por Thompson, Laura L., McManus, Kirk J.
Publicado 2015

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells

por Sajesh, Babu V., McManus, Kirk J.
Publicado 2015

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer

por Jeusset, Lucile M-P., McManus, Kirk J.
Publicado 2017

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

por Jeusset, Lucile M-P, McManus, Kirk J
Publicado 2019

Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells

por Sajesh, Babu V, Lichtensztejn, Zelda, McManus, Kirk J
Publicado 2013

Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer

por Campos Gudiño, Rubi, McManus, Kirk J., Hombach-Klonisch, Sabine
Publicado 2023

Synthetic Genetic Targeting of Genome Instability in Cancer

por Sajesh, Babu V., Guppy, Brent J., McManus, Kirk J.
Publicado 2013

The synthetic lethal killing of RAD54B-deficient colorectal cancer cells by PARP1 inhibition is enhanced with SOD1 inhibition

por McAndrew, Erin N., Lepage, Chloe C., McManus, Kirk J.
Publicado 2016

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis

por Baergen, Allison K., Jeusset, Lucile M., Lichtensztejn, Zelda, McManus, Kirk J.
Publicado 2019

Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes

por Leylek, Tarik R., Jeusset, Lucile M., Lichtensztejn, Zelda, McManus, Kirk J.
Publicado 2020

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

por Lepage, Chloe C., Thompson, Laura L., Larson, Bradley, McManus, Kirk J.
Publicado 2020

Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover

por Thompson, Laura L., Baergen, Allison K., Lichtensztejn, Zelda, McManus, Kirk J.
Publicado 2020

Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells

por Sajesh, Babu V., Bailey, Melanie, Lichtensztejn, Zelda, Hieter, Philip, McManus, Kirk J.
Publicado 2013

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability

por Thompson, Laura L., Rutherford, Kailee A., Lepage, Chloe C., McManus, Kirk J.
Publicado 2021

A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members

por Campos Gudiño, Rubi, Farrell, Ally C., Neudorf, Nicole M., McManus, Kirk J.
Publicado 2021

Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability

por Thompson, Laura L., Rutherford, Kailee A., Lepage, Chloe C., McManus, Kirk J.
Publicado 2022

Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer

por Liu, Qian, Huang, Shujun, Desautels, Danielle, McManus, Kirk J., Murphy, Leigh, Hu, Pingzhao
Publicado 2023

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer

por Thompson, Laura L., Jeusset, Lucile M-P., Lepage, Chloe C., McManus, Kirk J.
Publicado 2017