Developing tools for defining and establishing pathways of toxicity

por Andersen, Melvin E., McMullen, Patrick D., Krewski, Daniel
Publicado 2015

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

por Guisbert, Eric, Czyz, Daniel M., Richter, Klaus, McMullen, Patrick D., Morimoto, Richard I.
Publicado 2013

Motif-based zwitterionic peptides impact their structure and immunogenicity

por McMullen, Patrick, Qiao, Qi, Luozhong, Sijin, Cai, Lirong, Fang, Liang, Shao, Qing, Jiang, Shaoyi
Publicado 2022

Hidden hydrophobicity impacts polymer immunogenicity

por Yuan, Zhefan, McMullen, Patrick, Luozhong, Sijin, Sarker, Pranab, Tang, Chenjue, Wei, Tao, Jiang, Shaoyi
Publicado 2023

Beyond Pharmaceuticals: Fit-for-Purpose New Approach Methodologies for Environmental Cardiotoxicity Testing

por Daley, Mark C., Mende, Ulrike, Choi, Bum-Rak, McMullen, Patrick D., Coulombe, Kareen L. K.
Publicado 2023

MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells

por Deisenroth, Chad, Black, Michael B., Pendse, Salil, Pluta, Linda, Witherspoon, Sam M., McMullen, Patrick D., Thomas, Russell S.
Publicado 2014

De novo design of functional zwitterionic biomimetic material for immunomodulation

por Li, Bowen, Yuan, Zhefan, Jain, Priyesh, Hung, Hsiang-Chieh, He, Yuwei, Lin, Xiaojie, McMullen, Patrick, Jiang, Shaoyi
Publicado 2020

RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days

por Black, Michael B., Andersen, Melvin E., Pendse, Salil N., Borghoff, Susan J., Streicker, Michael, McMullen, Patrick D.
Publicado 2021

Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress

por McMullen, Patrick D., Aprison, Erin Z., Winter, Peter B., Amaral, Luis A. N., Morimoto, Richard I., Ruvinsky, Ilya
Publicado 2012

Comparative transcriptomics and eQTL mapping of response to Melampsora americana in selected Salix purpurea F(2) progeny

por Wilkerson, Dustin G., Crowell, Chase R., Carlson, Craig H., McMullen, Patrick W., Smart, Christine D., Smart, Lawrence B.
Publicado 2022

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

por Clewell, Rebecca A., Sun, Bin, Adeleye, Yeyejide, Carmichael, Paul, Efremenko, Alina, McMullen, Patrick D., Pendse, Salil, Trask, O. J., White, Andy, Andersen, Melvin E.
Publicado 2014

A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation

por Haider, Saad, Black, Michael B., Parks, Bethany B., Foley, Briana, Wetmore, Barbara A., Andersen, Melvin E., Clewell, Rebecca A., Mansouri, Kamel, McMullen, Patrick D.
Publicado 2018

The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium

por Fasani, Rick A., Livi, Carolina B., Choudhury, Dipanwita R., Kleensang, Andre, Bouhifd, Mounir, Pendse, Salil N., McMullen, Patrick D., Andersen, Melvin E., Hartung, Thomas, Rosenberg, Michael
Publicado 2016

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

por Bhattacharya, Sudin, Shoda, Lisl K.M., Zhang, Qiang, Woods, Courtney G., Howell, Brett A., Siler, Scott Q., Woodhead, Jeffrey L., Yang, Yuching, McMullen, Patrick, Watkins, Paul B., Andersen, Melvin E.
Publicado 2012

Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods

por Nicolas, Chantel I., Linakis, Matthew W., Minto, Melyssa S., Mansouri, Kamel, Clewell, Rebecca A., Yoon, Miyoung, Wambaugh, John F., Patlewicz, Grace, McMullen, Patrick D., Andersen, Melvin E., Clewell III, Harvey J.
Publicado 2022

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation

por Moreau, Marjory, Mallick, Pankajini, Smeltz, Marci, Haider, Saad, Nicolas, Chantel I., Pendse, Salil N., Leonard, Jeremy A., Linakis, Matthew W., McMullen, Patrick D., Clewell, Rebecca A., Clewell, Harvey J., Yoon, Miyoung
Publicado 2022

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

por Pendse, Salil N., Maertens, Alexandra, Rosenberg, Michael, Roy, Dipanwita, Fasani, Rick A., Vantangoli, Marguerite M., Madnick, Samantha J., Boekelheide, Kim, Fornace, Albert J., Odwin, Shelly-Ann, Yager, James D., Hartung, Thomas, Andersen, Melvin E., McMullen, Patrick D.
Publicado 2016

The Human Toxome Project

por Bouhifd, Mounir, Andersen, Melvin E., Baghdikian, Christina, Boekelheide, Kim, Crofton, Kevin M., Fornace, Albert J., Kleensang, Andre, Li, Henghong, Livi, Carolina, Maertens, Alexandra, McMullen, Patrick D., Rosenberg, Michael, Thomas, Russell, Vantangoli, Marguerite, Yager, James D., Zhao, Liang, Hartung, Thomas
Publicado 2015

A toxicogenomic approach for the risk assessment of the food contaminant acetamide

por Nault, Rance, Bals, Bryan, Teymouri, Farzaneh, Black, Michael B., Andersen, Melvin E., McMullen, Patrick D., Krishnan, Seetha, Kuravadi, Nagesh, Paul, Neetha, Kumar, Santhosh, Kannan, Kamala, Jayachandra, K.C., Alagappan, Lakshmanan, Patel, Bhavesh Dhirajlal, Bogen, Kenneth T., Gollapudi, Bhaskar B., Klaunig, James E., Zacharewski, Tim R., Bringi, Venkataraman
Publicado 2020

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of...

por Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Böttger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Craig Rowlands, J., Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Donato, María Teresa, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sá, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Gómez-Lechón, María José, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Häussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhütter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Kevin Park, B., Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stöber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.
Publicado 2013