Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity

por Budworth, Helen, McMurray, Cynthia T.
Publicado 2016

A Double-Pronged Sword: XJB-5-131 Is a Suppressor of Somatic Instability and Toxicity in Huntington’s Disease

por Wipf, Pater, Polyzos, Aris A., McMurray, Cynthia T.
Publicado 2022

Cockayne Syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

por Kovtun, Irina V., Johnson, Kurt O., McMurray, Cynthia T.
Publicado 2011

Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons

por Trushina, Eugenia, Rana, Sandeep, McMurray, Cynthia T, Hua, Duy H
Publicado 2009

Folate deficiency drives mitotic missegregation of the human FRAXA locus

por Bjerregaard, Victoria A., Garribba, Lorenza, McMurray, Cynthia T., Hickson, Ian D., Liu, Ying
Publicado 2018

Distinct Pools of Non-Glycolytic Substrates Differentiate Brain Regions and Prime Region-Specific Responses of Mitochondria

por Lee, Do Yup, Xun, Zhiyin, Platt, Virginia, Budworth, Helen, Canaria, Christie A., McMurray, Cynthia T.
Publicado 2013

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

por Polyzos, Aris A., Wood, Nigel I., Williams, Paul, Wipf, Peter, Morton, A. Jennifer, McMurray, Cynthia T.
Publicado 2018

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

por Lai, Yanhao, Budworth, Helen, Beaver, Jill M., Chan, Nelson L. S., Zhang, Zunzhen, McMurray, Cynthia T., Liu, Yuan
Publicado 2016

Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair

por Laverde, Eduardo E., Polyzos, Aris A., Tsegay, Pawlos P., Shaver, Mohammad, Hutcheson, Joshua D., Balakrishnan, Lata, McMurray, Cynthia T., Liu, Yuan
Publicado 2022

An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

por Lovergne, Lila, Ghosh, Dhruba, Schuck, Renaud, Polyzos, Aris A., Chen, Andrew D., Martin, Michael C., Barnard, Edward S., Brown, James B., McMurray, Cynthia T.
Publicado 2021

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

por Budworth, Helen, Harris, Faye R., Williams, Paul, Lee, Do Yup, Holt, Amy, Pahnke, Jens, Szczesny, Bartosz, Acevedo-Torres, Karina, Ayala-Peña, Sylvette, McMurray, Cynthia T.
Publicado 2015